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2,4-Dibromothiazole

2,4-Dibromothiazole structure

CAS No.: 4175-77-3

Chemical Name:: 2,4-Dibromothiazole

Synonyms: 2,4-Dibromo-1,3-thiazole;2,4-BROMOTHIAZOLE;2,4-Dibrmothiazole;2,4-dibormothiazole;2,4-DIBROMOTHIAZOLE;2,4-Dibromothiazole>Thiazole, 2,4-dibroMo-;2,4-DIBROMOTHIAZOLE 98%;2,4-Dibromothiazole ,98%;2,4-DIBROMOTHIAZOLE, 97+%

CBNumber:: CB0179775

Molecular Formula:: C3HBr2NS

Molecular Weight:: 242.92

MDL Number:: MFCD01318994

MOL File:: 4175-77-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:21:03

Product description	Number	Pack Size	Price
2,4-Dibromothiazole 97%	677914	5g	$42.3
2,4-Dibromothiazole 97%	677914	1g	$25
2,4-Dibromothiazole >98.0%(GC)	D3667	1g	$22
2,4-Dibromothiazole >98.0%(GC)	D3667	5g	$46
2,4-Dibromothiazole Asreported	270871	5g	$333
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2,4-Dibromothiazole Properties

Melting point	80-84 °C
Boiling point	242.8±13.0 °C(Predicted)
Density	2.324±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	-1.93±0.10(Predicted)
form	powder to crystal
color	White to Light yellow
InChI	InChI=1S/C3HBr2NS/c4-2-1-7-3(5)6-2/h1H
InChIKey	MKEJZKKVVUZXIS-UHFFFAOYSA-N
SMILES	S1C=C(Br)N=C1Br
CAS DataBase Reference	4175-77-3(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Xn,Xi

Risk Statements

22-37/38-41-36/37/38

Safety Statements

26-39-36-37/39

WGK Germany

Hazard Note

Harmful

HazardClass

IRRITANT, KEEP COLD

HS Code

29349990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

2,4-Dibromothiazole price More Price(119)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	677914	2,4-Dibromothiazole 97%	4175-77-3	5g	$42.3	2026-04-30	Buy
Sigma-Aldrich	677914	2,4-Dibromothiazole 97%	4175-77-3	1g	$25	2023-06-20	Buy
TCI Chemical	D3667	2,4-Dibromothiazole >98.0%(GC)	4175-77-3	1g	$22	2026-04-30	Buy
TCI Chemical	D3667	2,4-Dibromothiazole >98.0%(GC)	4175-77-3	5g	$46	2026-04-30	Buy
Usbiological	270871	2,4-Dibromothiazole Asreported	4175-77-3	5g	$333	2026-06-03	Buy

Product number	Packaging	Price	Buy
677914	5g	$42.3	Buy
677914	1g	$25	Buy
D3667	1g	$22	Buy
D3667	5g	$46	Buy
270871	5g	$333	Buy

2,4-Dibromothiazole Chemical Properties,Uses,Production

Chemical Properties

Off-white crystalline powder

Uses

2,4-Dibromothiazole is an intermediate used in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modula tors.

Uses

2,4-Dibromothiazole is applied as a building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain. It is also used as an intermediate in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modulators.

Uses

Building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain.

Synthesis

2295-31-0

4175-77-3

General procedure for the synthesis of 2,4-dibromothiazoles from 2,4-thiazolidinediones: Example 41: Preparation of 2-amino-3-methyl-5-(3-pyrimidin-5-ylphenyl)-5-(1,3-thiazol-4-yl)-3,5-dihydro-4H-imidazol-4-one Step a) Preparation of compound 2 A mixture of 2,4-thiazolidinedione 1 (2.28 g, 19.5 mmol) with phosphorus tribromide (25.0 g, 87.0 mmol) was heated at 130°C for 30 min and subsequently cooled to room temperature. The reaction mixture was diluted with ice water (300 mL) and neutralized by batchwise addition of solid sodium carbonate. After neutralization was complete, the mixture was extracted with dichloromethane (3 x 150 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (silica gel, elution gradient: 0:100 to 5:95 ethyl acetate/hexane) to afford compound 2 (3.34 g, 71%) as light yellow crystals.1H NMR (500 MHz, CDCl3) δ 7.21 (s, 1H).

References

[1] Journal of Organic Chemistry, 2006, vol. 71, # 10, p. 3754 - 3761
[2] Synthesis, 2012, vol. 44, # 7, p. 1026 - 1029
[3] Journal of Materials Chemistry C, 2017, vol. 5, # 45, p. 11927 - 11936
[4] Patent: US2007/4786, 2007, A1. Location in patent: Page/Page column 21
[5] Tetrahedron, 2006, vol. 62, # 38, p. 9017 - 9037

2,4-Dibromothiazole Preparation Products And Raw materials

Raw materials

Phosphorus oxybromide PETROLEUM ETHER Phosphenous bromide (9CI) 2,4-Thiazolidinedione Sodium carbonate

1,3-THIAZOLIDIN-2-ONE

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Preparation Products

4-METHOXY-2-MORPHOLIN-4-YL-THIAZOLE-5-CARBALDEHYDE 4-Bromothiazole ETHYL 4-BROMOTHIAZOLE-2-CARBOXYLATE 2,4-DIBROMO-THIAZOLE-5-CARBALDEHYDE,97% 4-BROMO-2-METHYLTHIAZOLE

2,4,5-TribroMothiazole 5-bromo-2-propan-2-yloxy-1,3-thiazole (2,4-DibroMothiazol-5-yl)(phenyl)Methanone 2-Bromo-5-(tributylstannyl)thiazole 4-BroMo-2-(2-Methylbut-3-en-2-yl)thiazole

tert-Butyl (1-(4-bromothiazol-2-yl)piperidin-4-yl)carbamate

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2,4-Dibromothiazole Suppliers

Global( 381)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-15225627621 +86-13213167925	jiuyitime@fdachem.com	China	16511	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58

Supplier	Advantage
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58

View Lastest Price from 2,4-Dibromothiazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-02	2,4-Dibromothiazole 4175-77-3	$1.60-6.60	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-06-30	2,4-Dibromothiazole 4175-77-3		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-06-27	2,4-Dibromothiazole 4175-77-3		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

2,4-Dibromothiazole
4175-77-3
$1.60-6.60
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

2,4-Dibromothiazole
4175-77-3
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

2,4-Dibromothiazole
4175-77-3
$0.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

2,4-Dibromothiazole Spectrum

2,4-Dibromothiazole(4175-77-3)¹HNMR

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2,4-DIBROMOTHIAZOLE 2,4-BROMOTHIAZOLE 2,4-DIBROMOTHIAZOLE 98% 2,4-Dibromothiazole ,98% 2,4-DIBROMOTHIAZOLE, 97+% 2,4-Dibrmothiazole 2,4-dibormothiazole Thiazole, 2,4-dibroMo- 2,4-Dibromothiazole> TIANFU-CHEM 2,4-Dibromothiazole 4175-77-3 2,4-Dibromo-1,3-thiazole 4175-77-3 C3HBr2NS C3HNBr2S Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks ThiazolesHeterocyclic Building Blocks Halogenated Organohalides Thiazole Thiazoles blocks Bromides