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2,4-Dibromothiazole

2,4-Dibromothiazole Structure
2,4-Dibromothiazole structure
CAS No.
4175-77-3
Chemical Name:
2,4-Dibromothiazole
Synonyms
2,4-Dibromo-1,3-thiazole;2,4-BROMOTHIAZOLE;2,4-Dibrmothiazole;2,4-dibormothiazole;2,4-DIBROMOTHIAZOLE;2,4-Dibromothiazole>Thiazole, 2,4-dibroMo-;2,4-DIBROMOTHIAZOLE 98%;2,4-Dibromothiazole ,98%;2,4-DIBROMOTHIAZOLE, 97+%
CBNumber:
CB0179775
Molecular Formula:
C3HBr2NS
Molecular Weight:
242.92
MDL Number:
MFCD01318994
MOL File:
4175-77-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:21:03
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2,4-Dibromothiazole Properties

Melting point 80-84 °C
Boiling point 242.8±13.0 °C(Predicted)
Density 2.324±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
pka -1.93±0.10(Predicted)
form powder to crystal
color White to Light yellow
InChI InChI=1S/C3HBr2NS/c4-2-1-7-3(5)6-2/h1H
InChIKey MKEJZKKVVUZXIS-UHFFFAOYSA-N
SMILES S1C=C(Br)N=C1Br
CAS DataBase Reference 4175-77-3(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-37/38-41-36/37/38
Safety Statements  26-39-36-37/39
WGK Germany  3
Hazard Note  Harmful
HazardClass  IRRITANT, KEEP COLD
HS Code  29349990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2,4-Dibromothiazole price More Price(107)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 677914 2,4-Dibromothiazole 97% 4175-77-3 5g $42.3 2026-04-30 Buy
Sigma-Aldrich 677914 2,4-Dibromothiazole 97% 4175-77-3 1g $25 2023-06-20 Buy
TCI Chemical D3667 2,4-Dibromothiazole >98.0%(GC) 4175-77-3 1g $22 2026-04-30 Buy
TCI Chemical D3667 2,4-Dibromothiazole >98.0%(GC) 4175-77-3 5g $46 2026-04-30 Buy
Usbiological 270871 2,4-Dibromothiazole Asreported 4175-77-3 5g $333 2026-06-03 Buy
Product number Packaging Price Buy
677914 5g $42.3 Buy
677914 1g $25 Buy
D3667 1g $22 Buy
D3667 5g $46 Buy
270871 5g $333 Buy

2,4-Dibromothiazole Chemical Properties,Uses,Production

Chemical Properties

Off-white crystalline powder

Uses

2,4-Dibromothiazole is an intermediate used in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modula tors.

Uses

2,4-Dibromothiazole is applied as a building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain. It is also used as an intermediate in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modulators.

Uses

Building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain.

Synthesis

2,4-Thiazolidinedione

2295-31-0

2,4-Dibromothiazole

4175-77-3

General procedure for the synthesis of 2,4-dibromothiazoles from 2,4-thiazolidinediones: Example 41: Preparation of 2-amino-3-methyl-5-(3-pyrimidin-5-ylphenyl)-5-(1,3-thiazol-4-yl)-3,5-dihydro-4H-imidazol-4-one Step a) Preparation of compound 2 A mixture of 2,4-thiazolidinedione 1 (2.28 g, 19.5 mmol) with phosphorus tribromide (25.0 g, 87.0 mmol) was heated at 130°C for 30 min and subsequently cooled to room temperature. The reaction mixture was diluted with ice water (300 mL) and neutralized by batchwise addition of solid sodium carbonate. After neutralization was complete, the mixture was extracted with dichloromethane (3 x 150 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (silica gel, elution gradient: 0:100 to 5:95 ethyl acetate/hexane) to afford compound 2 (3.34 g, 71%) as light yellow crystals.1H NMR (500 MHz, CDCl3) δ 7.21 (s, 1H).

References

[1] Journal of Organic Chemistry, 2006, vol. 71, # 10, p. 3754 - 3761
[2] Synthesis, 2012, vol. 44, # 7, p. 1026 - 1029
[3] Journal of Materials Chemistry C, 2017, vol. 5, # 45, p. 11927 - 11936
[4] Patent: US2007/4786, 2007, A1. Location in patent: Page/Page column 21
[5] Tetrahedron, 2006, vol. 62, # 38, p. 9017 - 9037

2,4-Dibromothiazole Preparation Products And Raw materials

Raw materials

Phosphorus oxybromide PETROLEUM ETHER Phosphenous bromide (9CI) 2,4-Thiazolidinedione Sodium carbonate
1,3-THIAZOLIDIN-2-ONE

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Preparation Products

4-METHOXY-2-MORPHOLIN-4-YL-THIAZOLE-5-CARBALDEHYDE 4-Bromothiazole ETHYL 4-BROMOTHIAZOLE-2-CARBOXYLATE 2,4-DIBROMO-THIAZOLE-5-CARBALDEHYDE,97% 4-BROMO-2-METHYLTHIAZOLE
2,4,5-TribroMothiazole 5-bromo-2-propan-2-yloxy-1,3-thiazole (2,4-DibroMothiazol-5-yl)(phenyl)Methanone 2-Bromo-5-(tributylstannyl)thiazole 4-BroMo-2-(2-Methylbut-3-en-2-yl)thiazole
tert-Butyl (1-(4-bromothiazol-2-yl)piperidin-4-yl)carbamate

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2,4-Dibromothiazole Suppliers

Global( 384)Suppliers
Supplier Tel Email Country ProdList Advantage
Shandong Shining Pharm Co.,Ltd 18866891188 18866891188 zhaojiangxia@shiningpharm.com China 203 58
Nanjing Chemrui Pharmtech Co., Ltd. 86-25-58849758 13851795789 sales@chemrui.com China 47 62
Fuxin Kaituo Fine Chemical Technology Co., Ltd 15714082442 3757845877@qq.com China 343 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
ChemFuture PharmaTech (Jiangsu) Ltd 5108538618 suger.wang@chemfuture.com China 832 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Shandong Shining Pharm Co.,Ltd 58
Nanjing Chemrui Pharmtech Co., Ltd. 62
Fuxin Kaituo Fine Chemical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
ChemFuture PharmaTech (Jiangsu) Ltd 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

View Lastest Price from 2,4-Dibromothiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-Dibromothiazole pictures 2026-08-25 2,4-Dibromothiazole
4175-77-3
 $1.60-6.60 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2,4-Dibromothiazole pictures 2026-06-30 2,4-Dibromothiazole
4175-77-3
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2,4-Dibromothiazole pictures 2025-06-27 2,4-Dibromothiazole
4175-77-3
 1KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd

2,4-Dibromothiazole Spectrum

2,4-Dibromothiazole(4175-77-3)1HNMR

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2,4-DIBROMOTHIAZOLE 2,4-BROMOTHIAZOLE 2,4-DIBROMOTHIAZOLE 98% 2,4-Dibromothiazole ,98% 2,4-DIBROMOTHIAZOLE, 97+% 2,4-Dibrmothiazole 2,4-dibormothiazole Thiazole, 2,4-dibroMo- 2,4-Dibromothiazole> TIANFU-CHEM 2,4-Dibromothiazole 4175-77-3 2,4-Dibromo-1,3-thiazole 4175-77-3 C3HBr2NS C3HNBr2S Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks ThiazolesHeterocyclic Building Blocks Halogenated Organohalides Thiazole Thiazoles blocks Bromides