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2,4-Thiazolidinedione

2,4-Thiazolidinedione structure

CAS No.: 2295-31-0

Chemical Name:: 2,4-Thiazolidinedione

Synonyms: THIAZOLIDINE-2,4-DIONE;TZD;Thiazolidinedione;2,4-Thiazolidindione;U 25560;idinedione;usafek-5496;2,4-ThiazoL;USAF ek-5496;AURORA 23272

CBNumber:: CB6675365

Molecular Formula:: C3H3NO2S

Molecular Weight:: 117.13

MDL Number:: MFCD00005478

MOL File:: 2295-31-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:12

Product description	Number	Pack Size	Price
2,4-Thiazolidinedione technical grade, 90%	375004	25g	$86.7
2,4-Thiazolidinedione technical grade, 90%	375004	100g	$135
2,4-Thiazolidinedione >98.0%(GC)(T)	T1990	25g	$18
2,4-Thiazolidinedione >98.0%(GC)(T)	T1990	100g	$48
2,4-Thiazolidinedione >98.0%(GC)(T)	T1990	500g	$144
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2,4-Thiazolidinedione Properties

Melting point	125-127 °C (lit.)
Boiling point	178-179 °C (19 mmHg)
Density	1.408 (estimate)
vapor pressure	0Pa at 25℃
refractive index	1.5130 (estimate)
Flash point	178-179°C/19mm
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	6.50±0.10(Predicted)
form	Crystalline Powder
color	Slightly yellow
Water Solubility	Soluble in water (30 mg/ml at 3°C), methanol, DMSO, ethanol, and ethyl ether.
BRN	110700
InChI	1S/C3H3NO2S/c5-2-1-7-3(6)4-2/h1H2,(H,4,5,6)
InChIKey	ZOBPZXTWZATXDG-UHFFFAOYSA-N
SMILES	O=C1CSC(=O)N1
LogP	-0.29 at 25℃
CAS DataBase Reference	2295-31-0(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	AA68LXK93C
NIST Chemistry Reference	2,4-Thiazolidinedione(2295-31-0)
EPA Substance Registry System	2,4-Thiazolidinedione (2295-31-0)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Warning

Hazard statements

H301

Precautionary statements

P264-P270-P301+P310a-P321-P405-P501a

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

24/25-36-26

WGK Germany

RTECS

XJ5775000

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29341000

Storage Class

11 - Combustible Solids

NFPA 704

	0
1		0

2,4-Thiazolidinedione price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	375004	2,4-Thiazolidinedione technical grade, 90%	2295-31-0	25g	$86.7	2026-04-30	Buy
Sigma-Aldrich	375004	2,4-Thiazolidinedione technical grade, 90%	2295-31-0	100g	$135	2026-04-30	Buy
TCI Chemical	T1990	2,4-Thiazolidinedione >98.0%(GC)(T)	2295-31-0	25g	$18	2026-04-30	Buy
TCI Chemical	T1990	2,4-Thiazolidinedione >98.0%(GC)(T)	2295-31-0	100g	$48	2026-04-30	Buy
TCI Chemical	T1990	2,4-Thiazolidinedione >98.0%(GC)(T)	2295-31-0	500g	$144	2026-04-30	Buy

Product number	Packaging	Price	Buy
375004	25g	$86.7	Buy
375004	100g	$135	Buy
T1990	25g	$18	Buy
T1990	100g	$48	Buy
T1990	500g	$144	Buy

2,4-Thiazolidinedione Chemical Properties,Uses,Production

Chemical Properties

White to Off-White Powder

Uses

Inhibitor of enzyme

Uses

2,4-Thiazolidinedione may be used in the synthesis of sixteen 5-arylidene-2,4-thiazolidinediones, via ultrasound-promoted aldol condensation reaction. It may be used as starting material for the synthesis of drugs with antihyperglycemic activity.

Definition

ChEBI: A thiazolidenedione carrying oxo substituents at positions 2 and 4.

General Description

2,4-Thiazolidinedione is a well-known peroxisome proliferator-activated receptors (PPAR) activator. Its effect on aging process using kidneys from Fischer 344 rats has been reported. A library of conjugates of 2,4-thiazolidinedione has been synthesized by Knoevenagel condensation followed by reduction using hydrogen gas and Pd/C catalyst. Knoevenagel condensation of various aromatic aldehydes with 2,4-thiazolidinedione in polyethylene glycol-300 has been reported.

Flammability and Explosibility

Not classified

2,4-Thiazolidinedione synthesis

Synthesis of 2,4-Thiazolidinedione from Pseudothiohydantoin

2,4-Thiazolidinedione Preparation Products And Raw materials

Raw materials

Rhodanine

Preparation Products

Thiazole-5-carboxaldehyde Thiazole-4-carboxaldehyde Rosiglitazone 2,4-Dibromothiazole S49076

2,4-DIBROMO-THIAZOLE-5-CARBALDEHYDE,97% (2,4-DIOXO-1,3-THIAZOLIDIN-3-YL)ACETIC ACID 2,4-Dichlorothiazole 5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxyl]benzyldene}-2,4-thiazolidinedione 2,4-Dichloro-5-thiazolecarboxaldehyde

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2,4-Thiazolidinedione Suppliers

Global( 613)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	18895	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8612	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Dideu Industries Group Limited	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 2,4-Thiazolidinedione manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-05	2,4-Thiazolidinedione 2295-31-0	US $65.00-650.00 / KG	1KG	0.99	20 tons	Zibo Hangyu Biotechnology Development Co., Ltd
2026-04-29	2,4-Thiazolidinedione 2295-31-0	US $50.00-1000.00 / KG	1KG	0.99	10MT per month	Jinan Dexinjia Bio&Tech Co., Ltd
2026-03-20	2,4-Thiazolidinedione 2295-31-0	US $1.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

2,4-Thiazolidinedione
2295-31-0
US $65.00-650.00 / KG
0.99
Zibo Hangyu Biotechnology Development Co., Ltd

2,4-Thiazolidinedione
2295-31-0
US $50.00-1000.00 / KG
0.99
Jinan Dexinjia Bio&Tech Co., Ltd

2,4-Thiazolidinedione
2295-31-0
US $1.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2,4-Thiazolidinedione Spectrum

2,4-Thiazolidinedione(2295-31-0)MS 2,4-Thiazolidinedione(2295-31-0)¹HNMR 2,4-Thiazolidinedione(2295-31-0)¹³CNMR 2,4-Thiazolidinedione(2295-31-0)IR1 2,4-Thiazolidinedione(2295-31-0)IR2 2,4-Thiazolidinedione(2295-31-0)Raman

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2,4-Thiazolidinedione, 99% 100GR 2,4-Thiazolidinedione, 99% 25GR thiazolidin-2,4-dione 2,4-Thiazolidinedione technical grade, 90% 2, 4 - Margaret diketone OTAVA-BB BB7112440002 TZD TIMTEC-BB SBB000047 THIAZOLIDINE-2,4-DIONE 2,4(3H,5H)-Thiazoledione 2,4-Dioxothiazolidine Thiazolidinedione Thiazolidinedione-2,4 USAF ek-5496 usafek-5496 AURORA 23272 2,3,4,5-TETRAHYDROTHIAZOLE-2,4-DIONE 1,3-Thiazolane-2,4-dione 1,3-Thiazolane-2,4-dione, 2,4-Dioxo-1,3-thiazolidine 2,4-ThiazoL idinedione 1,3-THIAZOLIDINE-2,4-DIONE 2,4-DIKETOTHIAZOLIDINE 2,4-THIAZOLIDINEDIONE 2,4-Thiazolidinedione 、Thiazolidine-2,4-dione AKOS B029064 2,4-Thiadolidinedione 2,4(3H,5H)-Thiazoledion U 25560 2,4-Thiazolidinedione ,99% 2,4-Thiazolinedione 2,4-THIAZOLIDINEDIONE, TECH., 90% 2,4-Thiazolidindione 2,4-Thiazolidondione 2,4-Thiozolidinedione 1,3-Thiazolidine-2,4-dione 98% Thiazoline-2,4-dione(2,4-thiazolidinedion) 2,4-THIAZOLIDINEDIONE 98% 2,4-THIZAOLODINE 2,4-Thiazolidinedione > 2,4-Thiazolidinedione (P) Thiazolidin-2,4-dion Thiazolidinedione (6CI) Pioglitazone impurity thiazolidine-2,4-dione 2,4-Thiazolidinedione, 98% 2295-31-0 2295-31-2 C3H3NO2S C3H2KNO2S Building Blocks Heterocyclic Building Blocks Thiazoles Thiazolines/Thiazolidines Starting Raw Materials & Intermediates PHARMACEUTICAL INTERMEDIATES Sulphur Derivatives Sulfur compounds blocks