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4-Amino-2,6-difluoropyridine

4-Amino-2,6-difluoropyridine Structure
4-Amino-2,6-difluoropyridine structure
CAS No.
63489-58-7
Chemical Name:
4-Amino-2,6-difluoropyridine
Synonyms
2,6-difluoropyridin-4-aMine;2,6-difluoro-4-PyridinaMine;6-difluoropyridin-4-aMine;4-Amino-2,6-difluoropyridine;4-Pyridinamine, 2,6-difluoro-;2,,6-difluoro-4-aminopyridine;2,6-Difluoro-pyridin-4-ylamine;4-Amino-2,6-difluoropyridine 97%;4-Pyridinamine,2,6-difluoro-(9CI);4-AMINO-2,6-DIFLUOROPYRIDINE ISO 9001：2015 REACH
CBNumber:
CB0183286
Molecular Formula:
C5H4F2N2
Molecular Weight:
130.1
MDL Number:
MFCD08436089
MOL File:
63489-58-7.mol
MSDS File:
SDS
Last updated:2026-09-12 18:47:34
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4-Amino-2,6-difluoropyridine Properties

Melting point 124-125
Boiling point 267.8±35.0 °C(Predicted)
Density 1.393±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
form solid
pka -0.33±0.10(Predicted)
color Pale yellow
InChI InChI=1S/C5H4F2N2/c6-4-1-3(8)2-5(7)9-4/h1-2H,(H2,8,9)
InChIKey OWXBXLGJIFPPMS-UHFFFAOYSA-N
SMILES C1(F)=NC(F)=CC(N)=C1
CAS DataBase Reference 63489-58-7

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Warning
Hazard statements  H302-H312-H315-H319-H331-H335
Precautionary statements  P261-P280-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  T
RIDADR  2811
HazardClass  6.1
PackingGroup  Ⅲ
HS Code  2933399990

4-Amino-2,6-difluoropyridine price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC9706 4-Amino-2,6-difluoropyridine 97% 63489-58-7 100mg $21 2026-06-04 Buy
Apolloscientific PC9706 4-Amino-2,6-difluoropyridine 97% 63489-58-7 250mg $26 2026-06-04 Buy
Apolloscientific PC9706 4-Amino-2,6-difluoropyridine 97% 63489-58-7 1g $49 2026-06-04 Buy
Apolloscientific PC9706 4-Amino-2,6-difluoropyridine 97% 63489-58-7 5g $240 2026-06-04 Buy
Apolloscientific PC9706 4-Amino-2,6-difluoropyridine 97% 63489-58-7 25g $845 2026-06-04 Buy
Product number Packaging Price Buy
PC9706 100mg $21 Buy
PC9706 250mg $26 Buy
PC9706 1g $49 Buy
PC9706 5g $240 Buy
PC9706 25g $845 Buy

4-Amino-2,6-difluoropyridine Chemical Properties, Uses, Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 30, p. 340, 1987 DOI: 10.1021/jm00385a016

Synthesis

4-Amino-3,5-dichloro-2,6-difluoropyridine

2840-00-8

4-AMINO-2,6-DIFLUOROPYRIDINE

63489-58-7

In a 500 mL autoclave, 49.8 g (0.25 mol) of 2,6-difluoro-3,5-dichloro-4-aminopyridine, 200 mL of ethanol, 5.61 g (0.55 mol) of triethylamine, and 10.0 g of 10% palladium carbon catalyst were added. The reaction system was maintained at 25 °C and a hydrogen pressure of 0.46 MPa was applied and the reaction lasted for 24 hours. Upon completion of the reaction, the system was cooled and the hydrogen pressure was slowly released. The catalyst was removed by diafiltration followed by distillation under reduced pressure to remove the solvent. The crude product was purified by column chromatography using petroleum ether/ethyl acetate (3:1 v/v) as eluent. The final product was 20.6 g of 2,6-difluoro-4-aminopyridine as a white solid, which was determined to be 99.7% pure by liquid chromatographic normalization in 63.5% yield.

References

[1] Journal of Medicinal Chemistry, 1987, vol. 30, # 2, p. 340 - 347
[2] Patent: CN104610250, 2017, B. Location in patent: Paragraph 0076; 0077; 0079

4-Amino-2,6-difluoropyridine Preparation Products And Raw materials

Raw materials

4-Pyridinamine, 2,6-dichloro-N-(triphenylmethyl)- 4-Amino-3,5-dichloro-2,6-difluoropyridine Activated carbon Triethylamine Palladium
Ethanol

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Preparation Products

2(1H)-Pyridinone,4-amino-6-fluoro-(9CI) 2-Fluoro-6-methoxypyridin-4-amine 2,6-difluoropyridine-3,4-diaMine

4-Amino-2,6-difluoropyridine Suppliers

Global Suppliers ( 110)
Supplier Tel Email Country ProdList Advantage
BEIJINGYIWANJINGRUI 15866847540 dengyt2000@163.com China 4100 58
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Nanjing Lynsci Chemical Co., Ltd +86-025-83208253 +86-13851694729 layefe@163.com China 234 62
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4905 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Bellen Chemistry Co., Ltd. 010-60400365-8001 15910885229 service@bellenchem.com China 4514 60
Shanghai Haozhixiang Biotechnology Co., Ltd 526763801 13301653310 526763801@qq.com China 7982 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Supplier Advantage
BEIJINGYIWANJINGRUI 58
PharmaBlock Sciences (Nanjing),Inc. 55
Alfa Aesar 84
Nanjing Lynsci Chemical Co., Ltd 62
Shanghai Raise Chemical Technology Co.,Ltd 55
Bide Pharmatech Ltd. 60
Cool Pharm, Ltd 58
Bellen Chemistry Co., Ltd. 60
Shanghai Haozhixiang Biotechnology Co., Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60

View Latest Price from 4-Amino-2,6-difluoropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-6-Difluoropyridin-4-amine pictures 2026-09-14 2-6-Difluoropyridin-4-amine
63489-58-7
 $100.00 1KG 99% 1000 KG HANGZHOU DINGYAN CHEM CO.,LTD
4-AMINO-2,6-DIFLUOROPYRIDINE pictures 2026-08-07 4-AMINO-2,6-DIFLUOROPYRIDINE
63489-58-7
 $1.00-4.00 1KG 99% 200000KG Shaanxi Dideu Medichem Co. Ltd
4-AMINO-2,6-DIFLUOROPYRIDINE pictures 2026-06-30 4-AMINO-2,6-DIFLUOROPYRIDINE
63489-58-7
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

4-Amino-2,6-difluoropyridine Spectrum

4-AMINO-2,6-DIFLUOROPYRIDINE(63489-58-7)1HNMR4-AMINO-2,6-DIFLUOROPYRIDINE(63489-58-7)19FNMR

63489-58-7 (4-Amino-2,6-difluoropyridine) Related Search:

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2,,6-difluoro-4-aminopyridine 4-Pyridinamine,2,6-difluoro-(9CI) 6-difluoropyridin-4-aMine 4-Amino-2,6-difluoropyridine 97% 4-Pyridinamine, 2,6-difluoro- 4-AMINO-2,6-DIFLUOROPYRIDINE ISO 9001：2015 REACH 2,6-Difluoro-pyridin-4-ylamine 2,6-difluoropyridin-4-aMine 2,6-difluoro-4-PyridinaMine 4-Amino-2,6-difluoropyridine 63489-58-7 PYRIDINE