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ChemicalBook >> CAS DataBase List >>4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole Structure
4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole structure
CAS No.
1029413-53-3
Chemical Name:
4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole
Synonyms
4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole;tert-butyl3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 3-(4-amino-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester
CBNumber:
CB01856448
Molecular Formula:
C12H20N4O2
Molecular Weight:
252.31
MDL Number:
MFCD10687121
MOL File:
1029413-53-3.mol
MSDS File:
SDS
Last updated:2026-05-27 17:21:14
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4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole Properties

Boiling point 412.9±35.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 4.29±0.19(Predicted)
Appearance Brown to red Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 52117 4-AMINO-1-(1-BOC-PYRROLIDIN-3-YL)-1H-PYRAZOLE 97% 1029413-53-3 1G $54 2026-04-30 Buy
AstaTech 52117 4-AMINO-1-(1-BOC-PYRROLIDIN-3-YL)-1H-PYRAZOLE 97% 1029413-53-3 5G $259 2026-04-30 Buy
AstaTech 52117 4-AMINO-1-(1-BOC-PYRROLIDIN-3-YL)-1H-PYRAZOLE 97% 1029413-53-3 25G $834 2026-04-30 Buy
Biosynth ERB41353 4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole 1029413-53-3 5g $649 2026-06-04 Buy
Biosynth ERB41353 4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole 1029413-53-3 10g $843.7 2026-06-04 Buy
Product number Packaging Price Buy
52117 1G $54 Buy
52117 5G $259 Buy
52117 25G $834 Buy
ERB41353 5g $649 Buy
ERB41353 10g $843.7 Buy

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole Chemical Properties,Uses,Production

Uses

4-Amino-1-(1-boc-pyrrolidin-3-yl)-1h-pyrazole is a pyrazolamine derivative that can be prepared by alkylation of nitropyrazole with alcohol and subsequent reduction.

Synthesis

tert-butyl3-(4-nitro-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate

1056024-38-4

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole

1029413-53-3

(Step 3) Synthesis of tert-butyl 3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate:[0490] 3-(4-nitro-1H-pyrazol-1-yl)pyrrolidine-1-carboxylic acid tert-butyl ester (1.25 g, 4.43 mmol) was suspended in ethanol (EtOH, 30.0 mL) and 10% palladium/carbon (Pd/C, 0.30 g) was added. The reaction mixture was stirred overnight at room temperature under hydrogen atmosphere. Upon completion of the reaction, the mixture was filtered and the filter cake was washed with methanol (MeOH, 10.0 mL). The filtrates were combined and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography with a gradient of dichloromethane (DCM) to DCM/methanol (methanol solution containing 3M ammonia) as eluent (v/v=100/1 to 50/1) to afford the title compound as a brown viscous liquid (0.65 g, 58% yield). m/z MS (ESI, positive ion mode): 253.2 [M+H ]+; 1H NMR (400 MHz, CDCl3) δ (ppm): 7.16 (s, 1H), 7.01 (s, 1H), 4.79-4.67 (m, 1H), 3.82-3.73 (m, 1H), 3.70-3.44 (m, 3H), 2.90 (s, 2H), 2.36-2.24 (m, 2H), 1.45 (s, 9H).

References

[1] Tetrahedron Letters, 2008, vol. 49, # 18, p. 2996 - 2998
[2] Patent: WO2017/44434, 2017, A1. Location in patent: Paragraph 0490
[3] Patent: CN106478607, 2017, A. Location in patent: Paragraph 1043; 1044; 1045; 1046

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

tert-butyl3-(4-nitro-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate Palladium Activated carbon Hydrogen Ethanol

Preparation Products

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole Suppliers

Global( 31)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Chengdu Forest Science and Technology Development Co., Ltd. 18030648795 18030648795 sales@cdforestchem.com China 1997 58
Chengdu J&B Technology Co., Ltd. 028-61186694 15608078506 609128801@qq.com China 853 55
parabiochem 025-83453382-8005 sale@parabiochem.com China 9577 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Aikon International Limited 025-58859352 13913916777 dt3@aikonchem.com China 15490 58
3A Chemicals 400-668-9898 service@3achem.com China 20535 58
Shanghai SPAR pharmaceutical technology co., LTD 021-000000 admin@jingshipharmatech.com China 9919 58
AFINE CHEMICALS LIMITED +86-571-85134551 +86-18958018566 info@afinechem.com China 15030 58
Supplier Advantage
Wuhan Chemwish Technology Co., Ltd 56
Adamas Reagent, Ltd. 59
Chengdu Forest Science and Technology Development Co., Ltd. 58
Chengdu J&B Technology Co., Ltd. 55
parabiochem 55
Amadis Chemical Company Limited 58
Aikon International Limited 58
3A Chemicals 58
Shanghai SPAR pharmaceutical technology co., LTD 58
AFINE CHEMICALS LIMITED 58

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole Spectrum

4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole(1029413-53-3)1HNMR

1029413-53-3(4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole)Related Search:

Pyrazole tert-butyl3-(4-nitro-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate 1-Pyrrolidinecarboxylic acid, 3-(4-bromo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester, (3R)- 1-Pyrrolidinecarboxylic acid, 3-(4-bromo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester, (3S)- 1-Pyrrolidinecarboxylic acid, 3-(4-iodo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester, (3R)-
R-4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole

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4-Amino-1-(1-Boc-pyrrolidin-3-yl)-1H-pyrazole tert-butyl3-(4-amino-1H-pyrazol-1-yl)pyrrolidine-1-carboxylate 1-Pyrrolidinecarboxylic acid, 3-(4-amino-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester 1029413-53-3