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3,5-Dibenzyloxyacetophenone

3,5-Dibenzyloxyacetophenone Structure
3,5-Dibenzyloxyacetophenone structure
CAS No.
28924-21-2
Chemical Name:
3,5-Dibenzyloxyacetophenone
Synonyms
3';TerbutalineImpurity46;Terbutaline Impurity 1;Terbutaline Impurity 5;3,5-benzyloxy Acetophenone;3,5-Dibenxyloxyacetophenone;3,5-DIBENZYLOXYACETOPHENONE;3, 5-dibenzoxy acetophenone;3,5-Dibenzyloxybenzophenone;3',5'-DIBENZYLOXYACETPHENONE
CBNumber:
CB0185952
Molecular Formula:
C22H20O3
Molecular Weight:
332.39
MDL Number:
MFCD00004777
MOL File:
28924-21-2.mol
MSDS File:
SDS
Last updated:2026-05-27 17:21:23
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3,5-Dibenzyloxyacetophenone Properties

Melting point 60-62 °C (lit.)
Boiling point 429.52°C (rough estimate)
Density 1.1079 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Soluble in dichloromethane, ethyl acetate and methanol
form Solid
color Off-White to Pale Yellow
InChI InChI=1S/C22H20O3/c1-17(23)20-12-21(24-15-18-8-4-2-5-9-18)14-22(13-20)25-16-19-10-6-3-7-11-19/h2-14H,15-16H2,1H3
InChIKey KOJXGMJOTRYLBD-UHFFFAOYSA-N
SMILES C(=O)(C1=CC(OCC2=CC=CC=C2)=CC(OCC2=CC=CC=C2)=C1)C
CAS DataBase Reference 28924-21-2(CAS DataBase Reference)
FDA UNII K8HQL6DG8R
EPA Substance Registry System Ethanone, 1-[3,5-bis(phenylmethoxy)phenyl]- (28924-21-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29145090
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
1
0 0

3,5-Dibenzyloxyacetophenone price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 215341 3,5-Dibenzyloxyacetophenone 98% 28924-21-2 50g $216 2023-06-20 Buy
TCI Chemical D2085 3',5'-Dibenzyloxyacetophenone 28924-21-2 10g $185 2026-04-30 Buy
TRC TRC-D417970-5G 3’,5’-Dibenzyloxyacetophenone 28924-21-2 5g $119 2026-06-03 Buy
TRC TRC-D417970-250MG 3’,5’-Dibenzyloxyacetophenone 28924-21-2 250mg $65 2026-06-03 Buy
TRC TRC-D417970-2.5G 3’,5’-Dibenzyloxyacetophenone 28924-21-2 2.5g $78 2026-06-03 Buy
Product number Packaging Price Buy
215341 50g $216 Buy
D2085 10g $185 Buy
TRC-D417970-5G 5g $119 Buy
TRC-D417970-250MG 250mg $65 Buy
TRC-D417970-2.5G 2.5g $78 Buy

3,5-Dibenzyloxyacetophenone Chemical Properties, Uses, Production

Preparation

Over 1.5 hours, methyllithium (531 mL 2 mol solution, 1.06 M) was added to a rapidly stirred solution of 3,5-dibenzyloxybenzoic acid (175 g, 0.532 M) in diethyl ether (250 mL) and tetrahydrofuran (1400 mL) at 15°–20°C. After stirring for another 0.75 hours at 10°–15°C, water (600 mL) was slowly added, maintaining the reaction temperature below 20°C. The aqueous layer was separated and extracted with diethyl ether (3 × 250 mL). The combined organic phases were washed with saturated sodium chloride solution (4 × 300 mL), dried over sodium sulfate, and concentrated under vacuum to give an oil that slowly crystallized from isopropyl ether. The crude product was recrystallized from diethyl ether-hexane to give 104.7 g. (59%) 3,5-Dibenzyloxyacetophenone; melting point 59°-61° C.

Chemical Properties

beige crystalline powder. 

Uses

3,5-Dibenzyloxyacetophenone is used in the synthesis of enantiomerically pure B-ring modified analogs of (-)-epicatechin gallate.

Uses

The product 3,5-dibenzyloxyacetophenone is widely used as intermediate in the production of a pharmaceutical for treatment of obesity, diabetes, glaucoma, AIDS, HIV infection, antiinflammatory effects, and also in the treatment of disorders which result from leukotriene, tranquilizers, hypotensives, diuretics, and antiglaucoma agents.[1]

References

[1] Ganapati D. Yadav,  Omprakash V. Badure. “Selective acylation of 1,3-dibenzyloxybenzene to 3,5-dibenzyloxyacetophenone over cesium modified dodecatungstophosphoric acid (DTP) on clay.” Applied Catalysis A: General 348 1 (2008): Pages 16-25.

3,5-Dibenzyloxyacetophenone synthesis

51863-60-6
100-39-0
28924-21-2
Synthesis of 3,5-Dibenzyloxyacetophenone from 3,5-Dihydroxyacetophenone and Benzyl bromide

3,5-Dibenzyloxyacetophenone Preparation Products And Raw materials

Raw materials

Ethanone, 1-[3,5-bis(phenylmethoxy)phenyl]-, oxime Ethanone, 1-[3,5-bis(phenylmethoxy)phenyl]-2-(methylsulfonyl)- 3,5-Dibenzyloxybenzoic acid 3,5-Bis(benzyloxy)benzoic acid benzyl ester Benzyl chloride
Benzyl bromide

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Preparation Products

Benzenemethanol, α-(bromomethyl)-3,5-bis(phenylmethoxy)-, (αS)- 3,5-Dihydroxyacetophenone 1-Chloro-3-ethoxypropane 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol

3,5-Dibenzyloxyacetophenone Suppliers

Global Suppliers ( 398)
Supplier Tel Email Country ProdList Advantage
JIANGYIN RUISHIPHARM CO.,LIMITED 0510-0510-66227179 18921203887 sales@ruishipharm.com China 747 58
Guangdong wengjiang Chemical Reagent Co., Ltd. 0751-2815688 13927872512 3007421951@qq.com China 9996 58
Jiangxi Boyang Pharmaceutical Chemical Co., Ltd. 15870608400 717293806@qq.com China 34 58
Shengyang Runze (Beijing) Technology Co., 17611011830 lyt001@syrz01.com China 179 58
Yancheng Yuntao Chemical Co., Ltd. 13512592619 2838893166@qq.com China 103 58
NINGBO SYNTAME BIOTECH CO LTD +86-0574-28802872 18668283131 sales@syntame.com China 114 58
Huaian Jiamu Biotechnology Co., Ltd. 0517-83187139 18205232085 cai@jiamu-bio.com China 2999 58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD 0755-83725350 13380397412 3001280422@qq.com China 10000 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Supplier Advantage
JIANGYIN RUISHIPHARM CO.,LIMITED 58
Guangdong wengjiang Chemical Reagent Co., Ltd. 58
Jiangxi Boyang Pharmaceutical Chemical Co., Ltd. 58
Shengyang Runze (Beijing) Technology Co., 58
Yancheng Yuntao Chemical Co., Ltd. 58
NINGBO SYNTAME BIOTECH CO LTD 58
Huaian Jiamu Biotechnology Co., Ltd. 58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62

View Latest Price from 3,5-Dibenzyloxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,5-Dibenzyloxyacetophenone pictures 2026-06-30 3,5-Dibenzyloxyacetophenone
28924-21-2
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
3,5-Dibenzyloxyacetophenone pictures 2026-03-20 3,5-Dibenzyloxyacetophenone
28924-21-2
 $1.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
3,5-Dibenzyloxyacetophenone pictures 2025-07-29 3,5-Dibenzyloxyacetophenone
28924-21-2
 $6.00 1kg 99% 2000KG/Month HebeiShuoshengImportandExportco.,Ltd

3,5-Dibenzyloxyacetophenone Spectrum

3,5-Dibenzyloxyacetophenone(28924-21-2)MS3,5-Dibenzyloxyacetophenone(28924-21-2)1HNMR3,5-Dibenzyloxyacetophenone(28924-21-2)13CNMR3,5-Dibenzyloxyacetophenone(28924-21-2)IR13,5-Dibenzyloxyacetophenone(28924-21-2)IR23,5-Dibenzyloxyacetophenone(28924-21-2)Raman

28924-21-2 (3,5-Dibenzyloxyacetophenone) Related Search:

4'-Methylacetophenone 3-Nitroacetophenone 4'-Hydroxyacetophenone Acetophenone 2-Bromoacetophenone
3,5-Diacetoxyacetophenone 4-Nitroacetophenone 3',5'-Dimethoxyacetophenone 4'-Bromoacetophenone 4-Methoxybenzylchloride
3,5-Bis(benzyloxy)benzoic acid benzyl ester 5-(1-Hydroxy-2-tert-butylamino-ethyl)benzene-1,3-diol 1-[3,5-bis(phenylmethoxy)phenyl]-2-bromoethan-1-one N-tert-butyldibenzylamine Terbutaline IMpurity 8
Terbutaline IMpurity B Terbutaline Impurity 4 1-(3,5-Dihydroxyphenyl)-2-[(1,1-dimethylethyl)amino]-ethanone, hydrochloride

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3,5-DIBENZYLOXYACETOPHENONE 3',5'-DIBENZYLOXYACETPHENONE 3',5'-BIS(BENZYLOXY)ACETOPHENONE 1-[3,5-bis(phenylmethoxy)phenyl]-ethanon 1-[3,5-Bis(benzyloxy)phenyl]ethan-1-one Terbutaline Impurity 1 3',5'-Dibenzyloxyacetophenone 3,5-Dibenzyloxyacetophenone (3,5-BIS-BENZYLOXY-PHENYL)-METHANOL Terbutaline3,5-DibenzylOxyAcetophenone 3,5-Dibenxyloxyacetophenone 3,5-2-Benzyloxy acetophenone Ethanone, 1-[3,5-bis(phenylmethoxy)phenyl]- 1-[3,5-Bis(phenylmethoxy)phenyl]ethanone 3,5-Dibenzyloxyacetophenone,98% 3',5'-Dibenzyloxyacetophenone 98% 1-[3,5-bis(benzyloxy)phenyl]ethanone 1-[3,5-Bis(benzyloxy)phenyl]ethan-1-one 98% Terbutaline Impurity 5 3, 5-dibenzoxy acetophenone CAS No.28924-21-2 3,5-Dibenzyloxyacetophenone TERBUTALINE SULFATE intermediates TerbutalineImpurity46 3,5-benzyloxy Acetophenone 1-[3,5-bis(phenylmeChemicalbookthoxy)phenyl]-ethanon 3',5'-Dibenzyloxyacetophenone 3' 3,5-Dibenzyloxybenzophenone 1-(3,5-Bis(benzyloxy)phenyl)ethan-1-one - [B92882] 3',5'-dibenzenemethoxybenzenethylone 3,5-Dibenzyloxyacetophenone,Terbutaline Impurity 28924-21-2 728924-18-7 C22H20O3 C6H5CH2O2C6H3COCH3 Organic Building Blocks Ketones C15 to C38 Carbonyl Compounds Building Blocks Building Blocks for Dendrimers Aromatic Acetophenones & Derivatives (substituted) API intermediates Building Blocks for Dendrimers Functional Materials Aromatics C15 to C38 Carbonyl Compounds Ketones bc0001 28924-21-2