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4'-Methylacetophenone

4'-Methylacetophenone Structure
4'-Methylacetophenone structure
CAS No.
122-00-9
Chemical Name:
4'-Methylacetophenone
Synonyms
4-METHYLACETOPHENONE;P-METHYLACETOPHENONE;1-(p-tolyl)ethan-1-one;FEMA 2677;P-ACETYLTOLUENE;p-Acetotoluene;4-ACETYLTOLUENE;1-p-tolyl-ethanone;Yellow sweet clover;4'-Methylacetophenon
CBNumber:
CB5852945
Molecular Formula:
C9H10O
Molecular Weight:
134.18
MDL Number:
MFCD00008751
MOL File:
122-00-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:17:14
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4'-Methylacetophenone Properties

Melting point 22-24 °C (lit.)
Boiling point 226 °C (lit.)
Density 1.004 g/mL at 20 °C 1.005 g/mL at 25 °C (lit.)
vapor pressure 0.52 hPa (25 °C)
FEMA 2677 | 4'-METHYLACETOPHENONE
refractive index n20/D 1.533(lit.)
FLAVIS Number 07.022 | 4-Methylacetophenone
Flash point 198 °F
storage temp. Store below +30°C.
solubility 2.07g/l
form Liquid
color Clear colorless to pale yellow
Odor at 10.00 % in dipropylene glycol. hawthorn sweet mimosa coumarin cherry acetophenone
Odor Type floral
biological source synthetic
explosive limit 1.00%(V)
Water Solubility 0.37 g/L (15 ºC)
JECFA Number 807
BRN 606053
Henry's Law Constant 1.8×100 mol/(m3Pa) at 25℃, Ji et al. (2008)
Cosmetics Ingredients Functions FRAGRANCE
InChI 1S/C9H10O/c1-7-3-5-9(6-4-7)8(2)10/h3-6H,1-2H3
InChIKey GNKZMNRKLCTJAY-UHFFFAOYSA-N
SMILES CC(=O)c1ccc(C)cc1
LogP 2.1 at 25℃
CAS DataBase Reference 122-00-9(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) 4'-METHYLACETOPHENONE
FDA UNII AX66V0KX3Y
NIST Chemistry Reference Ethanone, 1-(4-methylphenyl)-(122-00-9)
EPA Substance Registry System Ethanone, 1-(4-methylphenyl)- (122-00-9)
UNSPSC Code 85151701
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315
Precautionary statements  P264-P270-P280-P301+P312-P302+P352-P332+P313
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn
Risk Statements  36/37/38-22-20/21/22
Safety Statements  26-27-37/39-24/25-23-36
RIDADR  UN 1325 4.1/PG 2
WGK Germany  3
RTECS  AM9463000
TSCA  TSCA listed
HS Code  29143900
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Skin Irrit. 2
Toxicity LD50 orally in Rabbit: 1400 mg/kg LD50 dermal Rabbit > 2000 mg/kg
REACH Registrations Active
NFPA 704
1
0 0

4'-Methylacetophenone price More Price(82)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W267708 4′-Methylacetophenone ≥95%, FCC, FG 122-00-9 1 each $58 2026-04-30 Buy
Sigma-Aldrich W267708 4′-Methylacetophenone ≥95%, FCC, FG 122-00-9 1kg $101 2026-04-30 Buy
Sigma-Aldrich W267708 4′-Methylacetophenone ≥95%, FCC, FG 122-00-9 5kg $375 2026-04-30 Buy
Sigma-Aldrich W267708 4′-Methylacetophenone ≥95%, FCC, FG 122-00-9 10Kg $616 2026-04-30 Buy
Sigma-Aldrich W267708 4′-Methylacetophenone ≥95%, FCC, FG 122-00-9 25kg $1420 2026-04-30 Buy
Product number Packaging Price Buy
W267708 1 each $58 Buy
W267708 1kg $101 Buy
W267708 5kg $375 Buy
W267708 10Kg $616 Buy
W267708 25kg $1420 Buy

4'-Methylacetophenone Chemical Properties,Uses,Production

Description

4'-Methylacetophenone has a fruity, floral odor resembling acetophenone and a sweet, strawberry-like flavor. May be prepared by slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.

Chemical Properties

4'-Methylacetophenone has been identified in Brazilian rosewood oil and in pepper. It occurs as colorless crystals with a floral, sweet odor that is milder than that of acetophenone. 4-Methylacetophenone is prepared from toluene and acetic anhydride or acetyl chloride by a Friedel–Crafts reaction. It is used for blossom notes in mimosaand hawthorn-type perfumes, especially soap perfumes.

Occurrence

Reported found in the essential oil distilled from the wood of Myrocarpus fastigiatus, Myrocarpus frondo sus, Bois de Rose. Also reported found in sour cherry, orange and grapefruit peel oil, black currants, guava, peach, blackberry, celery, potato, tomato, mentha oils, pepper, parsley, smoked fish, cognac, parmesan cheese, cocoa, tea, soybean, cloudberry, mango, cauliflower, broccoli, rice bran, buckwheat, dried bonito, cherimoya, calabash nutmeg and mastic gum leaf oil, cooked cabbage, mandarin juice.

Uses

4'-Methylacetophenone is a methylated acteophenone used in cosmetics and perfumery. The presence of 4'-Methylacetophenone has been shown to accelerate the photopolymerization of Methyl methacrylate.

Uses

4'-Methylacetophenone is used as a flavoring agent. It reacts with morpholine to get 4-(p-tolyl-thioacetyl)-morpholine in the presence of sulfur as a reagent. Further, it is used as an intermediate in the manufacture of active pharmaceutical ingredients, perfumes and cosmetics.

Preparation

By slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the temperature at +5°C and then letting it increase to +20°C.

Definition

ChEBI: 4'-Methylacetophenone is an aromatic ketone. It is a metabolite found in or produced by Saccharomyces cerevisiae.

Taste threshold values

Taste characteristics at 20 ppm: sweet, creamy, fruity, cherry and heliotropine-like.

Synthesis Reference(s)

Journal of the American Chemical Society, 110, p. 2560, 1988 DOI: 10.1021/ja00216a032
Tetrahedron Letters, 27, p. 2965, 1986 DOI: 10.1016/S0040-4039(00)84691-2

General Description

4′-Methylacetophenone is a clear colourless to pale yellowish liquid that occurs naturally in mango, tomato and orange.

Safety Profile

Moderately toxic by ingestion. A human skin irritant. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

Purification Methods

Impurities, including the o-and m-isomers, are removed by forming the semicarbazone (m 212-213.5o) which, after repeated crystallisation, is hydrolysed to the ketone. [Brown & Marino J Am Chem Soc 84 1236 1962.] It can also be purified by distillation under reduced pressure, followed by low temperature crystallisation from isopentane. [Beilstein 7 IV 701.]

4'-Methylacetophenone synthesis

766-97-2
122-00-9
Synthesis of 4'-Methylacetophenone from 4-Ethynyltoluene

4'-Methylacetophenone Preparation Products And Raw materials

Raw materials

Benzyl chloride Acetyl chloride Aluminum chloride Semicarbazide

Preparation Products

4-[4-(Bromomethyl)phenyl]-1,2,3-thiadiazole 4-Acetylbenzoic acid 5-p-Tolyl-3H-thieno[2,3-d]pyrimidin-4-one 4-(1,2,3-Thiadiazol-4-yl)benzaldehyde 4-(4-Methylphenyl)-1,2,3-thiadiazole
4-(1,2,3-Thiadiazol-4-yl)benzoyl chloride CYAZOFAMID 4-Ethynyltoluene Ethyl 2-amino-4-(4-methylphenyl)-3-thiophenecarboxylate 4-(1,2,3-Thiadiazol-4-yl)benzylamine hydrochloride
Naphthalene, 1,2,3,4-tetrahydro-1,6-dimethyl-4-(1-methylethyl)-, (1R,4R)-rel- ar-turmerone 2-Bromo-4'-methylacetophenone Methyl 4-methylbenzoate 3,5-Dibromo-4-methylbenzoic acid
2-Amino-4-(p-tolyl)thiazole 1-(4-(Bromomethyl)phenyl)ethanone

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4'-Methylacetophenone Suppliers

Global( 831)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Chengyi Biotechnology Co., Ltd. 13338800824 3296343946@qq.com China 91 58
SINO HIGH(CHINA)CO.,LTD. 15295090350 13914336446 chang@sinohighchem.com China 40 58
NanJing JingWei Chemical Co., Ltd. 13270709979 njjwchem@163.com China 81 58
Wuhan Dongqi Chemical Co., Ltd 15307144961 18164002430 511710754@qq.com China 57 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 15995069468 15995069468 3398435160@qq.com China 300 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Changzhou Chengyi Biotechnology Co., Ltd. 58
SINO HIGH(CHINA)CO.,LTD. 58
NanJing JingWei Chemical Co., Ltd. 58
Wuhan Dongqi Chemical Co., Ltd 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84

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View Lastest Price from 4'-Methylacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-Methylacetophenone pictures 2026-09-13 4'-Methylacetophenone
122-00-9
 $10.00 1ASSAYS 99% 10 ton RongNa Biotechnology Co.,Ltd
4'-Methylacetophenone pictures 2026-09-11 4'-Methylacetophenone
122-00-9
 $2.00 1KG 99% 200mt/year Jinan Finer Chemical Co., Ltd
4'-Methylacetophenone pictures 2026-09-11 4'-Methylacetophenone
122-00-9
 $20.00 1KG 99% 300 Tons/ year Speranza Chemical Co., Ltd.

4'-Methylacetophenone Spectrum

4'-Methylacetophenone(122-00-9)MS4'-Methylacetophenone(122-00-9)1HNMR4'-Methylacetophenone(122-00-9)13CNMR4'-Methylacetophenone(122-00-9)IR14'-Methylacetophenone(122-00-9)IR24'-Methylacetophenone(122-00-9)Raman

122-00-9(4'-Methylacetophenone)Related Search:

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3'-(Trifluoromethyl)acetophenone 4'-Chloroacetophenone Tribenuron methyl 4'-Bromoacetophenone Thiophanate-methyl
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Acetophenone, 4'-methyl- Esberiven Ethanone,1-(4-methylphenyl)- Melilot Melilotal Sweet clover Yellow melilot 1-p-tolyl-ethanone 4’-methyl-acetophenon 4-METHYLACETOPHENONE 97+% 4-Methyacetophenone p-METHYLACETOPHENONE technical 4-Met-17Iyl acetopllenone p-Tolyl methyl ketone Methyl 4-methylphenyl ketone METHYLACETOPHENONE, 4-(SG) 4′-Methylacetophenone ,98% 4′-Methylacetophenone,Methyl p-tolyl ketone 4-Methylacetophenone, synthesis grade 1-(4-Methylphenyl)-1-ethanone 1-(4-Tolyl)ethanone 4-Methyl-1-acetylbenzene 4'-Methylacetophen 4-Methylhypnone The Methyl acetophenone 4'-Methylacetophenone Vetec(TM) reagent grade, 94% 4'-Methylacetophenone,95% (4-Methylphenyl) methyl ketone 1-(4-methylphenyl)-ethanon 1-(4-Methylphenyl)ethanone 1-(4-methyl-phenyl)-ethanone 1-(4-methylphenyl)-Ethanone 1-(4-Methylpheyl)ethanone BUTTPARK 41\03-57 METHYL P-TOLYL KETONE 1-(4-METHYLPHENYL)ETHAN-1-ONE 1-acetyl-4-methyl benzene 1-METHYL-4-ACETYLBENZENE 2-BROMO-1-(4-METHYLPHENYL)-1-ETHANONE 2-BROMO-1-(4-METHYLPHENYL)ETHANONE AKOS BBS-00003271 AKOS BBS-00000936 (4-METHYLPHENYL)ETHANONE 4-METHYLPHENACYL BROMIDE METHYLACETOPHENONE-4 METHYL 4-TOLYL KETONE 1-Methyl-4-acetylbenzen 4-Methylacetophenone (p-) p-methylphenyl methyl ketone 4'-Methylacetophenone 4-Acetyltoluene 4-Methylacetophenone Tolperisone Impurity G 1-(4-Methylpheyl)e Tolperisone Impurity 7 4'-METHYLACETOPHENONE 95+% FCC Ethanone, 1-(4-methylphenyl)- (9CI) 4-acetyltoluene,p-methylacetophenone,(p-methylphenyl)-methylketone P-Methyl 4'-(SG)