4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
![4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Structure](CAS/20180808/GIF/6975-75-3.gif)
- CAS No.
- 6975-75-3
- Chemical Name:
- 4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine
- Synonyms
- ILK-IN-3;ILK-IN-3 ，E0790;ILK-IN-3, 10 mM in DMSO;4-[2-(4-Methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine;antitumor,Integrin,inhibit,ILK,Inhibitor,ILK IN 3,ILKIN3;1H-Pyrazole-3,5-diamine, 4-[2-(4-methoxyphenyl)diazenyl]-;4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine;3-amino-4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazol-5-ylamine
- CBNumber:
- CB02111670
- Molecular Formula:
- C10H12N6O
- Molecular Weight:
- 232.24
- MDL Number:
- MFCD01239326
- MOL File:
- 6975-75-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 228-229 °C(Solvent: Ethanol; Water) |
|---|---|
| Boiling point | 566.022±50.00 °C(Press: 760.00 Torr)(predicted) |
| Density | 1.502±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: 83.33 mg/mL (358.81 mM) |
| form | Solid |
| pka | 12.430±0.10(predicted) |
| color | Light yellow to yellow |
| InChI | 1S/C10H12N6O/c1-17-7-4-2-6(3-5-7)13-14-8-9(11)15-16-10(8)12/h2-5H,1H3,(H5,11,12,15,16)/b14-13+ |
| InChIKey | QNRNTYHAOBVOKW-BUHFOSPRSA-N |
| SMILES | [nH]1nc(c(c1N)\N=N\c2ccc(cc2)OC)N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P501-P260-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | GAA97575 | 4-[2-(4-Methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine | 6975-75-3 | 25mg | $900 | 2026-06-04 | Buy |
| Biosynth | GAA97575 | 4-[2-(4-Methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine | 6975-75-3 | 50mg | $1064.5 | 2026-06-04 | Buy |
| Biosynth | GAA97575 | 4-[2-(4-Methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine | 6975-75-3 | 100mg | $1493 | 2026-06-04 | Buy |
| ChemScene | CS-0104348 | ILK-IN-3 99.62% | 6975-75-3 | 5mg | $87 | 2026-06-04 | Buy |
| ChemScene | CS-0104348 | ILK-IN-3 99.62% | 6975-75-3 | 10mg | $141 | 2026-06-04 | Buy |
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Chemical Properties, Uses, Production
Uses
ILK-IN-3 is an orally active integrin linked kinase (ILK) inhibitor. ILK-IN-3 improves the anticancer efficacy of Docetaxel (HY-B0011) in orthotopic LCC6 model[1][2].
Biological Activity
QLT0267 is an orally active, potent and selective integrin-linked kinase (ILK) inhibitor (IC50 = 26 nM; selectivity: >1000-fold over CK2, CSK, DNA-PK, PIM1, PKB/AKT, PKC, >100-fold over ERK1, GSK3β, LCK, PKA, p70S6K, and RSK1/QLT, >10-fold over CDK1/2/5) th at inhibits ILK-dependent cellular signaling (IC50 in 2h = 1 μM against 20 nM EGF-induced pAKT Ser473 phosphorylation in Hth74 cells). QLT0267 treatment causes thyroid cancer cell cycle arrest and apoptosis, leading to anti-proliferation efficacy in cultures (IC50 <6 μM; NPA187, DRO, and K4 cell lines) and in mice in vivo (DRO xenografts-derived tumor growth; 50-100 mg/kg via daily p.o.).
in vivo
ILK-IN-3 (QLT0267) (200 mg/kg; po; 28 days) Inhibits tumor growth in the in situ LCC6 model[1].
IC 50
DYRK1
References
[1] Jessica Kalra, et al. Validating the Use of a Luciferase Labeled Breast Cancer Cell Line, MDA435LCC6, as a Means to Monitor Tumor Progression and to Assess the Therapeutic Activity of an Established Anticancer Drug, Docetaxel (Dt) Alone or in Combination With the ILK Inhibitor, QLT0267. Cancer Biol Ther. 2011 May 1;11(9):826-38. DOI:10.4161/cbt.11.9.15183
[2] Mavrogeni ME, et al. A facile consensus ranking approach enhances virtual screening robustness and identifies a cell-active DYRK1α inhibitor. Future Med Chem. 2018 Oct;10(20):2411-2430. DOI:10.4155/fmc-2018-0198
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Preparation Products And Raw materials
4-[(E)-2-(4-methoxyphenyl)diazenyl]-1H-pyrazole-3,5-diamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55055611 18137792234 | 3957071458@qq.com | China | 9959 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
