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ChemicalBook >> CAS DataBase List >>4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Structure
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate structure
CAS No.
85547-56-4
Chemical Name:
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
Synonyms
PIPERAQUINE PHOSPHATE;Pipraquine Phosphate;Pipertaquine phosphate;antimalarial drugs PIPERAQUINE PHOSPHATE;2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline);4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate;Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-, phosphate;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP;Piperaquine PhosphateQ: What is Piperaquine Phosphate Q: What is the CAS Number of Piperaquine Phosphate Q: What is the storage condition of Piperaquine Phosphate Q: What are the applications of Piperaquine Phosphate
CBNumber:
CB02131090
Molecular Formula:
C29H32Cl2N6.H3PO4
Molecular Weight:
633.51
MDL Number:
MFCD08457544
MOL File:
85547-56-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
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4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Properties

storage temp. Store at -20°C
solubility DMSO: Insoluble;
form Solid
color Off-white to light yellow
Water Solubility Water: 2 mg/mL (3.16 mM)
InChIKey KATNPMSTHHZOTK-UHFFFAOYSA-N
SMILES C(N1CCN(C2=C3C(=NC=C2)C=C(Cl)C=C3)CC1)CCN1CCN(C2=C3C(=NC=C2)C=C(Cl)C=C3)CC1.P(O)(O)(O)=O
EWG's Food Scores 1
FDA UNII 5A17BAT3GK

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth KDA54756 Piperaquine phosphate 85547-56-4 25mg $240.75 2026-06-04 Buy
Biosynth KDA54756 Piperaquine phosphate 85547-56-4 50mg $447 2026-06-04 Buy
Biosynth KDA54756 Piperaquine phosphate 85547-56-4 100mg $825 2026-06-04 Buy
Biosynth KDA54756 Piperaquine phosphate 85547-56-4 250mg $1375 2026-06-04 Buy
Biosynth KDA54756 Piperaquine phosphate 85547-56-4 500mg $2065 2026-06-04 Buy
Product number Packaging Price Buy
KDA54756 25mg $240.75 Buy
KDA54756 50mg $447 Buy
KDA54756 100mg $825 Buy
KDA54756 250mg $1375 Buy
KDA54756 500mg $2065 Buy

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Chemical Properties, Uses, Production

Uses

Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2].

in vivo

Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mgh/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mgh/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1].

Animal Model:Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1]
Dosage:0, 10, 30, 90 mg/kg
Administration:A single i.p. administration
Result:The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
Animal Model:Male Swiss mice (6 weeks old)[1]
Dosage:90 mg/kg (Pharmacokinetic Analysis)
Administration:A single i.p. administration
Result:t1/2=17.8 d; AUC=33.5 mgh/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.

References

[1] Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11. DOI:10.1128/AAC.00878-07
[2] Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87. DOI:10.2165/00003495-200565010-00004

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Suppliers

Global Suppliers ( 98)
Supplier Tel Email Country ProdList Advantage
Chongqing Kanglle Pharmaceutical Co., Ltd -- cqkl@cqkl.com.cn China 48 51
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6741 52
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Hubei XinyuanShun Chemical Co., Ltd. 13971561712, 13995564702, 027-50664929 hbeixys2001@163.com China 3110 55
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 synchempharma@aliyun.com China 4988 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Raw material medicin reagent co.,Ltd sales@njromanme.com China 4511 58
Hubei widely chemical technology Co., Ltd. 027-83991130 18627774460 1718093273@QQ.COM China 1617 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
Chongqing Kanglle Pharmaceutical Co., Ltd 51
Shanghai Hanhong Scientific Co.,Ltd. 64
XiaoGan ShenYuan ChemPharm co,ltd 52
BOC Sciences 65
Hubei XinyuanShun Chemical Co., Ltd. 55
Shanghai Synchem Pharma Co., ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Raw material medicin reagent co.,Ltd 58
Hubei widely chemical technology Co., Ltd. 58
Amadis Chemical Company Limited 58

View Latest Price from 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP pictures 2026-08-20 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP
85547-56-4
 $1.10 1g 99.9% 100 Tons Min Dideu Industries Group Limited
Piperaquine phosphate pictures 2026-07-15 Piperaquine phosphate
85547-56-4
 99.17% 10g TargetMol Chemicals Inc.

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Spectrum

4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate(85547-56-4)1HNMR

85547-56-4 (4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate) Related Search:

Trisodium phosphate Piperaquine 1,1,1,2,3,3,3-Heptachloropropane Resin epoxy Sodium Phosphate Monobasic Monohydrate
Creatine phosphate 1-Chloropropane Ammonium dihydrogen phosphate Benproperine phosphate Primaquine diphosphate
Zinc phosphate Epichlorohydrin Clioquinol Calcium phosphate FERRIC PHOSPHATE
phosphate triphosphate 7-Chloroquinoline

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4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-, phosphate antimalarial drugs PIPERAQUINE PHOSPHATE 2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP Piperaquine PhosphateQ: What is Piperaquine Phosphate Q: What is the CAS Number of Piperaquine Phosphate Q: What is the storage condition of Piperaquine Phosphate Q: What are the applications of Piperaquine Phosphate Pipertaquine phosphate PIPERAQUINE PHOSPHATE Pipraquine Phosphate 85547-56-4 C29H35Cl2N6O4P