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| | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Basic information |
| Product Name: | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate | | Synonyms: | 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate;Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-, phosphate;antimalarial drugs PIPERAQUINE PHOSPHATE;2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline);4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP;Piperaquine PhosphateQ: What is
Piperaquine Phosphate Q: What is the CAS Number of
Piperaquine Phosphate Q: What is the storage condition of
Piperaquine Phosphate Q: What are the applications of
Piperaquine Phosphate;Pipertaquine phosphate | | CAS: | 85547-56-4 | | MF: | C29H32Cl2N6.H3PO4 | | MW: | 633.51 | | EINECS: | 1312995-182-4 | | Product Categories: | | | Mol File: | 85547-56-4.mol |  |
| | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: Insoluble; | | form | Solid | | color | Off-white to light yellow | | Water Solubility | Water: 2 mg/mL (3.16 mM) | | InChIKey | KATNPMSTHHZOTK-UHFFFAOYSA-N | | SMILES | C(N1CCN(C2=C3C(=NC=C2)C=C(Cl)C=C3)CC1)CCN1CCN(C2=C3C(=NC=C2)C=C(Cl)C=C3)CC1.P(O)(O)(O)=O |
| | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Usage And Synthesis |
| Uses | Piperaquine phosphate is a bisquinoline antimalarial agent. Piperaquine phosphate can be used in antimalarial research in combination with Artemisinin[1][2]. | | in vivo | Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice[1].
Piperaquine (90 mg/kg; a single i.p.) exhibits the t1/2, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mgh/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mgh/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice[1]. | Animal Model: | Male BALB/c mice (7 to 8 weeks) are inoculated with Plasmodium berghei parasites[1] | | Dosage: | 0, 10, 30, 90 mg/kg | | Administration: | A single i.p. administration | | Result: | The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
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| Animal Model: | Male Swiss mice (6 weeks old)[1] | | Dosage: | 90 mg/kg (Pharmacokinetic Analysis) | | Administration: | A single i.p. administration | | Result: | t1/2=17.8 d; AUC=33.5 mgh/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg. |
| | References | [1] Moore BR, et, al. Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model. Antimicrob Agents Chemother. 2008 Jan; 52(1): 306-11. DOI:10.1128/AAC.00878-07
[2] Davis TME, et, al. Piperaquine: a resurgent antimalarial drug. Drugs. 2005; 65(1): 75-87. DOI:10.2165/00003495-200565010-00004 |
| | 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate Preparation Products And Raw materials |
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