Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Indole-4-carboxaldehyde

Indole-4-carboxaldehyde

Indole-4-carboxaldehyde Structure
Indole-4-carboxaldehyde structure
CAS No.
1074-86-8
Chemical Name:
Indole-4-carboxaldehyde
Synonyms
4-INDOLECARBALDEHYDE;1H-INDOLE-4-CARBALDEHYDE;4-FLUOROINDOLE;1H-INDOLE-4-CARBOXALDEHYDE;4-FORMYLINDOLE;NSC 337264;e-4-carboxaL;INDOLE-4-ALDEHYDE;4-Formyl-1H-indole;RARECHEM AH BS 0110
CBNumber:
CB0217303
Molecular Formula:
C9H7NO
Molecular Weight:
145.16
MDL Number:
MFCD01632221
MOL File:
1074-86-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-08 07:26:47
Request For Quotation

Indole-4-carboxaldehyde Properties

Melting point 139-143 °C(lit.)
Boiling point 339.1±15.0 °C(Predicted)
Density 1.278±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMF: 10 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form powder to crystal
pka 15.84±0.30(Predicted)
color Light yellow to Brown
Water Solubility Soluble in ethanol and acetone. Insoluble in water.
Sensitive Air Sensitive
InChI InChI=1S/C9H7NO/c11-6-7-2-1-3-9-8(7)4-5-10-9/h1-6,10H
InChIKey JFDDFGLNZWNJTK-UHFFFAOYSA-N
SMILES N1C2=C(C(C=O)=CC=C2)C=C1
CAS DataBase Reference 1074-86-8(CAS DataBase Reference)
NIST Chemistry Reference 1H-indole-4-carboxaldehyde(1074-86-8)
UNSPSC Code 12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H317-H319
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36-43
Safety Statements  26-36/37
WGK Germany  3
Hazard Note  Irritant/Keep Cold
HazardClass  IRRITANT
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Sens. 1
NFPA 704
1
2 0

Indole-4-carboxaldehyde price More Price(103)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 632422 Indole-4-carboxaldehyde 97% 1074-86-8 1g $129 2023-06-20 Buy
Sigma-Aldrich 632422 Indole-4-carboxaldehyde 97% 1074-86-8 5g $628 2023-06-20 Buy
TCI Chemical I0712 Indole-4-carboxaldehyde >98.0%(GC) 1074-86-8 1g $136 2026-04-30 Buy
TCI Chemical I0712 Indole-4-carboxaldehyde >98.0%(GC) 1074-86-8 5g $340 2026-04-30 Buy
Cayman Chemical 10007086 4-formyl Indole ≥98% 1074-86-8 500mg $63 2026-04-30 Buy
Product number Packaging Price Buy
632422 1g $129 Buy
632422 5g $628 Buy
I0712 1g $136 Buy
I0712 5g $340 Buy
10007086 500mg $63 Buy

Indole-4-carboxaldehyde Chemical Properties,Uses,Production

Chemical Properties

White to dark brown solid

Uses

Indole-4-carboxaldehyde is usually used as reactant in Biginelli reaction,preparation of antitumor agents,intramolecular Friedel-Crafts acylation,preparation of inhibitors of cell division in E. Coli,synthesis of Hantzsch pyridine-containing Schiff bases.

Uses

4-Indolecarbaldehyde is a synthetic intermediate used for pharmaceutical synthesis. Also used as reactant in Biginelli reaction, synthesis of aurora kinase A inhibitors, preparation of antitumor agents, intermolecular Friedel-Crafts acylation, preparation of inhibitors of cell division in E. coli and synthesis of Hantzsch pyridine-containing Schiff bases.

Definition

ChEBI: Indole-4-carbaldehyde is a heteroarenecarbaldehyde that is indole in which the hydrogen at position 4 has been replaced by a formyl group. It has a role as an algal metabolite. It is a member of indoles and a heteroarenecarbaldehyde.

Synthesis Reference(s)

The Journal of Organic Chemistry, 46, p. 1752, 1981 DOI: 10.1021/jo00321a053
Tetrahedron, 39, p. 3695, 1983 DOI: 10.1016/S0040-4020(01)88608-7

General Description

Indole-4-carboxaldehyde participates in the synthesis of arcyriacyanin A. Synthesis of 4-indole-4-carboxaldehyde has been reported. Intramolecular Friedel-Crafts (FC) acylation of indole-4-carboxaldehyde has been reported.

Synthesis

Tetrapropylammonium perruthenate (0.3 g, 0.85 mmol) was added in portions to a mixture of alcohol product from 1H-Indole-4-Methanol (2.5 g, 17 mmol), N-methylmorpholine N-oxide (3.0 g, 25 mmol) and 4 A molecular sieves (3.0 g) in anhydrous methylene chloride (30 mL) at room temperature. The mixture was stirred at room temperature under nitrogen for 1 h and then filtered. The filtrate was concentrated in vacuo, and the residue was purified by chromatography (SiO2, CH2Cl2) to provide Indole-4-carboxaldehyde as a white powder (2.0 g, 80percent): 1H NMR (300 MHz, CDCl3) δ10.2 (s, 1H), 8.52 (br s, 1H), 7.64-7.69 (m, 2H), 7.31-7.44 (m, 3H), CI MS m/z=146 [C9H7NO+H]+.

References

[1] Journal of Organic Chemistry, 1980, vol. 45, # 16, p. 3350 - 3352
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 26, p. 5755 - 5775
[3] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 8, p. 983 - 988
[4] Patent: US2006/111385, 2006, A1. Location in patent: Page/Page column 20
[5] Chemistry Letters, 1980, p. 813 - 816

Indole-4-carboxaldehyde synthesis

1074-85-7
114615-82-6
1074-86-8
Synthesis of Indole-4-carboxaldehyde from INDOLE-4-METHANOL and Tetrapropylammonium perruthenate

Indole-4-carboxaldehyde Preparation Products And Raw materials

Raw materials

1H-Indole-4-carboxaldehyde, 1-[(4-methylphenyl)sulfonyl]- (E)-Methyl 2-(2-(diMethylaMino)vinyl)-3-nitrobenzoate INDOLE-4-METHANOL Methyl 2-methyl-3-nitrobenzoate 3-Nitro-o-xylene
4-Cyanoindole [(1H-Indol-4-yl)methyl](methyl)amine Methyl indole-4-carboxylate Tetrapropylammonium perruthenate N-ForMylsaccharin

1of2

Preparation Products

4-(Azetidin-1-ylMethyl)-1H-indole 1-(PHENYLMETHYL)-1H-INDOLE-4-CARBOXALDEHYDE (1-Methyl-1H-indol-4-yl)methanol

Indole-4-carboxaldehyde Suppliers

Global( 320)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuxi Pengruilai Trading Co.,Ltd 15370273536 18761559979 sales@zypharmchem.com China 90 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Bridge Organics +1269-649-4200 ab@bridgeorganics.com United States 160 55
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Wuxi Pengruilai Trading Co.,Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Bridge Organics 55
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Lastest Price from Indole-4-carboxaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Indole-4-carboxaldehyde pictures 2026-07-07 Indole-4-carboxaldehyde
1074-86-8
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
Indole-4-carboxaldehyde pictures 2021-08-12 Indole-4-carboxaldehyde
1074-86-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
Indole-4-carboxaldehyde pictures 2021-07-02 Indole-4-carboxaldehyde
1074-86-8
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

Indole-4-carboxaldehyde Spectrum

Indole-4-carboxaldehyde(1074-86-8)1HNMR

1074-86-8(Indole-4-carboxaldehyde)Related Search:

Indole-3-butyric acid Indometacin Formaldehyde Indole-3-acetic acid 3-FORMYLINDOLE,3-Indole Carboxaldehyde Indole-3-Carboxaldehyde,INDOLE-3-CARBOXALDEHYDE,1h-indole-3-carboxaldehyde
Indole 3-Cyanoindole Indoline-2-carboxylic acid Indole-4-boronic acid pinacol ester 3-Indoleacetonitrile
Methyl 3-cyanoindole-4-carboxylate 3-formyl-1H-Indole-4-carboxylic acid methyl ester Indol-1-yl-acetic acid 3-Indoleacrylic acid DL-Indole-3-lactic acid
Indole-4-carboxylic acid 7-FORMYLINDOLE,INDOLE-7-CARBOXALDEHYDE Methyl indole-4-carboxylate

1of4

1H-indol-4-carbaldehyde 1H-indole-4-carbaldehyde(SALTDATA: FREE) INDOLE-4-CARBALDEHYDE INDOLE-4-CARBOXALDEHYDE INDOLE-4-ALDEHYDE 4-INDOLE-CARBOXALDEHYDE Indole-4-carboxaldehyde 97% 4-Formyl-1H-indole 3-Indole Carboxyaldehyde 1H-Indole-4-carboxaldehyde (9CI) 1H-Indole-4-carboxaldehyde 98% RARECHEM AH BS 0110 NSC 337264 INDOLE-4-CARBOXALDEHYDE (4-FORMYLINDOLE) Indole-4-carboxaldehyde ,98% Indole-4-carboxaldehyde in stock Factory Indole-4-carboxaldehyde> e-4-carboxaL Indole-4-carboxaldehyde ISO 9001：2015 REACH Indole-4-carboxaldehyde (7CI, 8CI) Indol-4-carbaldehyde 4-FORMYLINDOLE 4-FLUOROINDOLE 1H-INDOLE-4-CARBALDEHYDE 1H-INDOLE-4-CARBOXALDEHYDE 4-INDOLECARBALDEHYDE 1074-86-8 41074-86-8 074-86-8 Building Blocks Indoles Heterocyclic Building Blocks Simple Indoles Building Blocks Indole Indoles IndolesOxindoles Indoles and derivatives pharmacetical Heterocycle-Indole series Aldehydes blocks ALDEHYDE