3-formyl-1H-Indole-4-carboxylic acid methyl ester
- CAS No.
- 53462-88-7
- Chemical Name:
- 3-formyl-1H-Indole-4-carboxylic acid methyl ester
- Synonyms
- Methyl 3-formyl-1H-indole-4-carboxylate;3-Formylindole-4-carboxylic acid methyl ester;3-Formyl-1H-indole-4-carboxylic acid methyl ester;methyl 3-formyl-1H-indole-4-carboxylate - [M86909];1H-indole-4-carboxylic acid, 3-formyl-, methyl ester;4-(Methoxycarbonyl)-1H-indole-3-carboxaldehyde, 3-Formyl-4-(methoxycarbonyl)-1H-indole
- CBNumber:
- CB61470842
- Molecular Formula:
- C11H9NO3
- Molecular Weight:
- 203.19
- MDL Number:
- MFCD06656838
- MOL File:
- 53462-88-7.mol
- MSDS File:
- SDS
| Melting point | 134-135 °C(Solv: benzene (71-43-2)) |
|---|---|
| Boiling point | 404.4±25.0 °C(Predicted) |
| Density | 1.341±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 14.30±0.30(Predicted) |
| Appearance | White to off-white Solid |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P271 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
3-formyl-1H-Indole-4-carboxylic acid methyl ester price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 64059 | METHYL 3-FORMYL-1H-INDOLE-4-CARBOXYLATE 97% | 53462-88-7 | 1G | $80 | 2026-04-30 | Buy |
| AstaTech | 64059 | METHYL 3-FORMYL-1H-INDOLE-4-CARBOXYLATE 97% | 53462-88-7 | 5G | $240 | 2026-04-30 | Buy |
| Matrix Scientific | 061425 | Methyl 3-formyl-1H-indole-4-carboxylate | 53462-88-7 | 500.00mg | $158 | 2026-05-18 | Buy |
| Synthonix | M86909 | methyl 3-formyl-1H-indole-4-carboxylate 97% | 53462-88-7 | 500mg | $24 | 2026-05-06 | Buy |
| Synthonix | M86909 | methyl 3-formyl-1H-indole-4-carboxylate 97% | 53462-88-7 | 1g | $30 | 2026-05-06 | Buy |
3-formyl-1H-Indole-4-carboxylic acid methyl ester Chemical Properties, Uses, Production
Synthesis
39830-66-5
68-12-2
53462-88-7
GENERAL STEPS: A dichloromethane (DCM) solution of 2M oxalyl dichloride (1.712 mL, 3.425 mmol) was added slowly and dropwise to ice-water-bath-cooled DCM (15 mL) under nitrogen protection. Subsequently, N,N-dimethylformamide (0.250 g, 3.425 mmol) was added dropwise and the reaction mixture was stirred at 0 °C for 30 min. Next, a solution of methyl 1H-indole-4-carboxylate (0.5 g, 2.854 mmol) in DCM (10 mL) was added. The reaction mixture was gradually warmed up to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the solvent was removed under reduced pressure. THF (15 mL) and 20% aqueous ammonium acetate were added to the residue and the mixture was stirred at reflux for 30 min at 70 °C. The reaction mixture was cooled and extracted with ethyl acetate. The organic phases were combined and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with 90% ethyl acetate/hexane as eluent to afford methyl 3-formyl-1H-indole-4-carboxylate (551 mg, 95.0% yield) as a white solid.LCMS m/z = 204.2 [M + H]+. 1H NMR (400 MHz, CDCl3) δ ppm: 4.00 (s, 3H), 7.34 ( t, J = 7.8 Hz, 1H), 7.63 (dd, J = 8.0 and 1.0 Hz, 1H), 7.87 (dd, J = 7.5 and 1.0 Hz, 1H), 8.10 (d, J = 3.2 Hz, 1H), 9.08 (br s, 1H), 10.53 (s, 1H).
References
[1] Patent: WO2016/176177, 2016, A1. Location in patent: Page/Page column 81
[2] Patent: CN103772395, 2016, B. Location in patent: Paragraph 0053-0057
[3] Patent: WO2013/37960, 2013, A1. Location in patent: Page/Page column 82
[4] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 6, p. 1793 - 1798
[5] Organic Letters, 2009, vol. 11, # 22, p. 5214 - 5217
3-formyl-1H-Indole-4-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
3-formyl-1H-Indole-4-carboxylic acid methyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Anhui Shite Pharmaceutical Technology Co., LTD | 086-21-50829787 13621628489 | sales1@stepuppharm.com | China | 253 | 55 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3980 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2277 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 3-formyl-1H-Indole-4-carboxylic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 3-formyl-1H-Indole-4-carboxylic acid methyl ester
53462-88-7
|
$5.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 3-formyl-1H-Indole-4-carboxylic acid methyl ester
53462-88-7
- $5.00
- 98%
- Career Henan Chemical Co
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