4-(3-Chloropropyl)morpholine
- CAS No.
- 7357-67-7
- Chemical Name:
- 4-(3-Chloropropyl)morpholine
- Synonyms
- N-(3-Chloropropyl)morpholine;Gefitinib iMpurity A;4-(3-ChL;NSC 38889;NSC 28831;)-morphoL;N-(3-Chloropropyl)M;IFLAB-BB F2108-0002;Gefitinib IMpurity VI;Gefitinib Impurity 81
- CBNumber:
- CB0240217
- Molecular Formula:
- C7H14ClNO
- Molecular Weight:
- 163.65
- MDL Number:
- MFCD00039714
- MOL File:
- 7357-67-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | NA |
|---|---|
| Boiling point | 115°C/25mmHg(lit.) |
| Density | 1.0409 g/cm3 |
| RTECS | QE0488000 |
| refractive index | 1.4720-1.4760 |
| Flash point | 91 °C |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Oil |
| pka | 7.03±0.10(Predicted) |
| Specific Gravity | 1.08 |
| color | Colourless to Yellow |
| InChI | InChI=1S/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2 |
| InChIKey | PQECODMSWJOUAT-UHFFFAOYSA-N |
| SMILES | N1(CCCCl)CCOCC1 |
| CAS DataBase Reference | 7357-67-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 82BVM8E6TN |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2934999090 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4-(3-Chloropropyl)morpholine price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2602 | 4-(3-Chloropropyl)morpholine >98.0%(GC)(T) | 7357-67-7 | 5g | $25 | 2026-04-30 | Buy |
| TCI Chemical | C2602 | 4-(3-Chloropropyl)morpholine >98.0%(GC)(T) | 7357-67-7 | 25g | $78 | 2026-04-30 | Buy |
| TRC | TRC-C379750-1G | 4-(3-Chloropropyl)morpholine | 7357-67-7 | 1g | $107 | 2026-06-03 | Buy |
| TRC | TRC-C379750-100MG | 4-(3-Chloropropyl)morpholine | 7357-67-7 | 100mg | $70 | 2026-06-03 | Buy |
| Biosynth | FC20377 | 4-(3-Chloropropyl)morpholine | 7357-67-7 | 50g | $150 | 2026-06-04 | Buy |
4-(3-Chloropropyl)morpholine Chemical Properties, Uses, Production
Description
4-(3-Chloropropyl)morpholine is a hydrochloride salt of the potent inhibitor 4-(3-chloropropyl)morpholine. It has an inhibitory effect on cancer, and is used in chromatographic science to separate amines from aliphatic hydrocarbons. 4-(3-Chloropropyl)morpholine inhibits epidermal growth factor (EGF) and has been shown to have a potent inhibitory effect on EGF receptor tyrosine kinase activity. It also inhibits the proliferation of cells by inhibiting DNA synthesis. This compound causes cell death through the inhibition of protein synthesis, which may be due to its ability to inhibit nucleophilic reactions that are involved in protein synthesis. 4-(3-Chloropropyl)morpholine can also fluoresce under UV light, which makes it useful for research purposes.
Chemical Properties
Pale Yellow Oil
Uses
Gefitinib intermediate.
Application
4-(3-Chloropropyl)morpholine is an organic synthetic reagent or pharmaceutical intermediate used in the synthesis of gefitinib. It has cancer-inhibiting properties and inhibits epidermal growth factor (EGF). It also inhibits cell proliferation by inhibiting DNA synthesis.
Synthesis
110-91-8
109-70-6
7357-67-7
To a solution of 1-bromo-3-chloropropane (10.0 g, 63.5 mmol) in toluene (100 mL) was slowly added morpholine (11.0 mL, 127 mmol). The reaction mixture was placed under reflux conditions with continuous stirring for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove insoluble impurities. The filtrate was washed sequentially with deionized water, and the organic layer was separated and dried over anhydrous sodium sulfate. The dried organic phase was concentrated under reduced pressure and subsequently purified by reduced pressure distillation to afford 4-(3-chloropropyl)morpholine (10.0 g, 96% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 3.70-3.80 (m, 4H), 3.60 (t, 2H), 2.40-2.60 (m, 6H), 1.90 (m, 2H). Mass spectrometry analysis showed a molecular ion peak (M + H) of 164.
References
[1] Patent: US2009/185999, 2009, A1
[2] Patent: US9133137, 2015, B2. Location in patent: Page/Page column 18-19
[3] Synthetic Communications, 2003, vol. 33, # 14, p. 2483 - 2486
[4] Journal of Organic Chemistry, 2010, vol. 75, # 4, p. 1155 - 1161
[5] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 4, p. 1066 - 1070
4-(3-Chloropropyl)morpholine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yangzhou Prince Chemical Co., Ltd | 0514-84248359 13328140016;15052570758;15949050037 | sales@princechem.com | China | 99 | 58 |
| Shandong Mingfeng Pharmaceutical and Technology Co. Ltd | 053155551677 15315114555 | 1345456643@qq.com | China | 298 | 58 |
| Shandong DexinyuanPharmaceutical and Technology Co. Ltd | 13583161331 | 81067618@qq.com | China | 122 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 94557 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 4-(3-Chloropropyl)morpholine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-(3-Chloropropyl)morpholine
7357-67-7
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-04-04 | N-(3-Chloropropyl)morpholine
7357-67-7
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-11-26 | 4-(3-Chloropropyl)morpholine
7357-67-7
|
1kg | 98% | Nanjing Fred Technology Co., Ltd |
-
- 4-(3-Chloropropyl)morpholine
7357-67-7
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- N-(3-Chloropropyl)morpholine
7357-67-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 4-(3-Chloropropyl)morpholine
7357-67-7
- $0.00
- 98%
- Nanjing Fred Technology Co., Ltd
