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WS 12

WS 12 Structure
WS 12 structure
CAS No.
68489-09-8
Chemical Name:
WS 12
Synonyms
WS 12;AR-15512;Cooler-12;Acoltremon, 97%;Acoltremon, 97%;Cooling agent WS12;Cooler than menthol;WS 12, TRPM8 agonist;WS-12, 10 mM in DMSO;N-(4-Methoxyphenyl)-p-menthane-3-carboxamide
CBNumber:
CB02455758
Molecular Formula:
C18H27NO2
Molecular Weight:
289.41
MDL Number:
MFCD11100191
MOL File:
68489-09-8.mol
MSDS File:
SDS
Last updated:2025-10-13 18:39:35
Product description Number Pack Size Price
WS-12 ≥98% (HPLC), powder W0519 5mg $194.75
WS12 ≥99%(HPLC) 3040 50 $590
WS12 ≥99%(HPLC) 3040 10 $141
WS12 W500040 10mg $105
WS12 W500040 25mg $210
More product size
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WS 12 Properties

Boiling point 447.8±28.0 °C(Predicted)
Density 1.029±0.06 g/cm3(Predicted)
vapor pressure 0-0Pa at 20-50℃
FEMA 4681 | (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
storage temp. -20°C
solubility DMSO: >20mg/mL
pka 14.18±0.70(Predicted)
form White to off-white powder.
color white to off-white
Odor at 100.00 %. cool minty
Odor Type minty
JECFA Number 2079
InChIKey HNSGVPAAXJJOPQ-XOKHGSTOSA-N
LogP 3.95 at 22℃ and pH7.7
Substances Added to Food (formerly EAFUS) (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
CAS DataBase Reference 68489-09-8
FDA UNII 1L7BVT4Z4Z
UNSPSC Code 12352200
NACRES NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS09
Signal word  Warning
Hazard statements  H410
Precautionary statements  P273-P391-P501
Hazard Codes  N
Risk Statements  50
Safety Statements  53-61
RIDADR  UN 3077 9 / PGIII

WS 12 price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W0519 WS-12 ≥98% (HPLC), powder 68489-09-8 5mg $194.75 2025-07-31 Buy
Tocris 3040 WS12 ≥99%(HPLC) 68489-09-8 50 $590 2021-12-16 Buy
Tocris 3040 WS12 ≥99%(HPLC) 68489-09-8 10 $141 2021-12-16 Buy
TRC W500040 WS12 68489-09-8 10mg $105 2021-12-16 Buy
TRC W500040 WS12 68489-09-8 25mg $210 2021-12-16 Buy
Product number Packaging Price Buy
W0519 5mg $194.75 Buy
3040 50 $590 Buy
3040 10 $141 Buy
W500040 10mg $105 Buy
W500040 25mg $210 Buy

WS 12 Chemical Properties,Uses,Production

Description

WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.

Chemical Properties

WS 12 is a odorless white crystalline solid,mp 178 °C, displaying a strong initial cooling effect and a long-lastingness. It is used particularly is oral care flavors.

Uses

WS 12 is a potent TRPM8 agonist.

Trade name

Winsense WS-12 (Renessenz)

Biological Activity

Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM).

Biochem/physiol Actions

WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.

storage

Store at -20°C

References

[1] SHERKHELI MA. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels.[J]. Pakistan journal of pharmaceutical sciences, 2008, 21 4: 370-378.
[2] BOYI LIU . TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain[J]. PAIN?, 2013, 154 10: Pages 2169-2177. DOI: 10.1016/j.pain.2013.06.043

WS 12 Preparation Products And Raw materials

Raw materials

Preparation Products

WS 12 Suppliers

Global( 161)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-17392712697 1022@dideu.com China 3996 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		+8613343047651 admin@zlchemi.com China 3692 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32434 58
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 8364 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Zhuoer Chemical Co., Ltd 		02120970332; +8613524231522 sales@zhuoerchem.com China 2904 58
Guangzhou TongYi biochemistry technology Co.,LTD 		+8613073028829 mack@tongyon.com China 2994 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Zhuanglai Chemical Trading Co.,Ltd 		58
career henan chemical co 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Shanghai UCHEM Inc. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Zhuoer Chemical Co., Ltd 		58
Guangzhou TongYi biochemistry technology Co.,LTD 		58

View Lastest Price from WS 12 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
WS-12 pictures 2025-10-14 WS-12
68489-09-8
 US $68.00-172.00 / mg 99.99% 10g TargetMol Chemicals Inc.
Cooling agent WS-12 pictures 2025-04-15 Cooling agent WS-12
68489-09-8
 US $25.00 / kg 1kg 99% 5000kg/week Hebei Zhuanglai Chemical Trading Co.,Ltd
WS 12 pictures 2024-07-18 WS 12
68489-09-8
 US $0.10 / KG 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
  • WS-12 pictures
  • WS-12
    68489-09-8
  • US $68.00-172.00 / mg
  • 99.99%
  • TargetMol Chemicals Inc.
  • WS 12 pictures
  • WS 12
    68489-09-8
  • US $0.10 / KG
  • 99.0%
  • Shaanxi Dideu Medichem Co. Ltd

WS 12 Spectrum

WS 12(68489-09-8)1HNMR

68489-09-8(WS 12)Related Search:

(2-(4-Iodophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium sodium salt WSB1 (A-10) WSP-5 5,7-Dihydro-2-methylthieno[3,4-d]pyrimidine WS6
WS3 WS-383 Menthoxypropanediol N-((Ethoxycarbonyl)methyl)-P-menthane-3-carboxamide 2-Isopropyl-N,2,3-trimethylbutyramide
WS 12

1of3

Cooling agent WS12 (1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide WS 12 (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide CyclohexanecarboxaMide, N-(4-Methoxyphenyl)-5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)- (2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)- N- (4- methoxy phenyl) - menthol -3- carboxylase N-(4-Methoxyphenyl)-p-menthane-3-carboxamide N-(4-Methoxyphenyl)-p-menthane-3-carboxamide(WS-12) Cooler than menthol AR-15512 Cooler-12 HEK293T,AVX 012,chronic neuropathic pain,TRP Channel,AR 15512,inhibit,AVX012,WS 12,WS12,WS-12,AR15512,AVX-012,Inhibitor,AR-15512,Transient receptor potential channels,analgesic effect,cultured mouse DRG neurons (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide WS 12, TRPM8 agonist (1R,2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide WS-12, 10 mM in DMSO Acoltremon, 97% Acoltremon, 97% 68489-09-8