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WS 12

WS 12 structure

CAS No.: 68489-09-8

Chemical Name:: WS 12

Synonyms: WS 12;AVX-012;AR-15512;Cooler-12;Acoltremon, 97%;Acoltremon, 97%;Cooling agent WS12;Cooler than menthol;WS 12, TRPM8 agonist;WS-12, 10 mM in DMSO

CBNumber:: CB02455758

Molecular Formula:: C18H27NO2

Molecular Weight:: 289.41

MDL Number:: MFCD11100191

MOL File:: 68489-09-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-24 22:25:33

Product description	Number	Pack Size	Price
WS-12 ≥98% (HPLC), powder	W0519	5mg	$220
WS-12 ≥98%	30352	5mg	$95
WS-12 ≥98%	30352	10mg	$131
WS-12 ≥98%	30352	50mg	$510
WS-12 ≥98%	30352	100mg	$922
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WS 12 Properties

Boiling point	447.8±28.0 °C(Predicted)
Density	1.029±0.06 g/cm3(Predicted)
vapor pressure	0-0Pa at 20-50℃
FEMA	4681 \| (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
FLAVIS Number	16.123 \| (1R,2S,5R)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide
storage temp.	-20°C
solubility	DMSO: >20mg/mL
pka	14.18±0.70(Predicted)
form	White to off-white powder.
color	white to off-white
Odor	at 100.00 %. cool minty
Odor Type	minty
JECFA Number	2079
InChI	1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16,17/m1/s1
InChIKey	HNSGVPAAXJJOPQ-XOKHGSTOSA-N
SMILES	COc1ccc(NC(=O)C2C[C@H](C)CC[C@H]2C(C)C)cc1
LogP	3.95 at 22℃ and pH7.7
CAS DataBase Reference	68489-09-8
Substances Added to Food (formerly EAFUS)	(1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE
FDA UNII	1L7BVT4Z4Z
UNSPSC Code	12352200
NACRES	NA.25

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H410
Precautionary statements	P273-P391-P501
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	N
Risk Statements	50
Safety Statements	53-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids
Hazard Classifications	Aquatic Acute 1 Aquatic Chronic 1
REACH Registrations	Active

WS 12 price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W0519	WS-12 ≥98% (HPLC), powder	68489-09-8	5mg	$220	2026-04-30	Buy
Cayman Chemical	30352	WS-12 ≥98%	68489-09-8	5mg	$95	2026-04-30	Buy
Cayman Chemical	30352	WS-12 ≥98%	68489-09-8	10mg	$131	2026-04-30	Buy
Cayman Chemical	30352	WS-12 ≥98%	68489-09-8	50mg	$510	2026-04-30	Buy
Cayman Chemical	30352	WS-12 ≥98%	68489-09-8	100mg	$922	2026-04-30	Buy

Product number	Packaging	Price	Buy
W0519	5mg	$220	Buy
30352	5mg	$95	Buy
30352	10mg	$131	Buy
30352	50mg	$510	Buy
30352	100mg	$922	Buy

WS 12 Chemical Properties,Uses,Production

Description

WS-12 is an agonist of transient receptor potential melastatin 8 (TRPM8). It induces currents in Xenopus oocytes expressing mouse TRPM8 (EC50 = 12 μM) and is selective for TRPM8 over transient receptor potential vanilloid 1-4 (TRPV1-4) and transient receptor potential ankyrin 1 (TRPA1) at 1 mM. WS-12 (6 nmol, i.c.v.) reduces nocifensive behavior induced by capsaicin in wild-type, but not Trpm8-/-, mice. It induces analgesia in the hot plate test, an effect that can be reversed by the opioid receptor antagonist naloxone, in mice.

Chemical Properties

WS 12 is a odorless white crystalline solid,mp 178 °C, displaying a strong initial cooling effect and a long-lastingness. It is used particularly is oral care flavors.

Uses

WS 12 is a potent TRPM8 agonist.

Trade name

Winsense WS-12 (Renessenz)

Biological Activity

Potent TRPM8 agonist that acts as a cooling agent (EC 50 = 193 nM).

Biochem/physiol Actions

WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.

storage

Store at -20°C

References

[1] SHERKHELI MA. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels.[J]. Pakistan journal of pharmaceutical sciences, 2008, 21 4: 370-378.
[2] BOYI LIU . TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain[J]. PAIN, 2013, 154 10: Pages 2169-2177. DOI: 10.1016/j.pain.2013.06.043

WS 12 Preparation Products And Raw materials

Raw materials

Preparation Products

WS 12 Suppliers

Global( 175)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3996	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8667	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Zhuoer Chemical Co., Ltd	02120970332; +8613524231522	sales@zhuoerchem.com	China	2904	58
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	tongyibiochem@163.com	China	2995	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
career henan chemical co	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Shanghai UCHEM Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Zhuoer Chemical Co., Ltd	58
Guangzhou TongYi biochemistry technology Co.,LTD	58

View Lastest Price from WS 12 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-11	WS-12 68489-09-8	US $68.00-172.00 / mg		99.99%	10g	TargetMol Chemicals Inc.
2025-12-24	WS 12 68489-09-8	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
2025-04-15	Cooling agent WS-12 68489-09-8	US $25.00 / kg	1kg	99%	5000kg/week	Hebei Zhuanglai Chemical Trading Co.,Ltd

WS-12
68489-09-8
US $68.00-172.00 / mg
99.99%
TargetMol Chemicals Inc.

WS 12
68489-09-8
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

Cooling agent WS-12
68489-09-8
US $25.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co.,Ltd

WS 12 Spectrum

WS 12(68489-09-8)¹HNMR

68489-09-8(WS 12)Related Search:

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WS6 WS3 Menthoxypropanediol N-((Ethoxycarbonyl)methyl)-P-menthane-3-carboxamide 2-Isopropyl-N,2,3-trimethylbutyramide

WS 12

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Cooling agent WS12 (1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexane-1-carboxamide WS 12 (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)cyclohexanecarboxamide CyclohexanecarboxaMide, N-(4-Methoxyphenyl)-5-Methyl-2-(1-Methylethyl)-, (1R,2S,5R)- (2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide (1R,2S,5R)-N-(4-METHOXYPHENYL)-5-METHYL-2-(1-METHYLETHYL)CYCLOHEXANECARBOXAMIDE Cyclohexanecarboxamide, N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl)- N- (4- methoxy phenyl) - menthol -3- carboxylase N-(4-Methoxyphenyl)-p-menthane-3-carboxamide N-(4-Methoxyphenyl)-p-menthane-3-carboxamide(WS-12) Cooler than menthol AR-15512 Cooler-12 HEK293T,AVX 012,chronic neuropathic pain,TRP Channel,AR 15512,inhibit,AVX012,WS 12,WS12,WS-12,AR15512,AVX-012,Inhibitor,AR-15512,Transient receptor potential channels,analgesic effect,cultured mouse DRG neurons (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide WS 12, TRPM8 agonist (1R,2S,5R)-2-isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide WS-12, 10 mM in DMSO Acoltremon, 97% Acoltremon, 97% (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(1-methyl)cyclohexylamide AVX-012 68489-09-8