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3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline structure

CAS No.: 154057-56-4

Chemical Name:: 3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline

Synonyms: 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-MethylBroMide;Pitavastatin bromide;-fluorophenyl)quinoline;Pitavastatin Impurity 68;3-(Bromomethyl)-2-cyclopropyl-4-(4'3-Hromomcthyy-2-cyclopropyl-4- 4-fluorophenylquinoline;Quinoline,3-(broMoMethyl)-2-cyclopropyl-4-(4-fluoropenyl);3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline;2-CYCLOPROPYL-3-(BROMOMETHYL)-4-(4-FLUOROPHENYL)-QUINOLINE;Quinoline, 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-

CBNumber:: CB02470335

Molecular Formula:: C19H15BrFN

Molecular Weight:: 356.23

MDL Number:: MFCD09031391

MOL File:: 154057-56-4.mol

MSDS File:: SDS

Last updated:2026-11-04 16:58:27

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3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Properties

Melting point	131-134°C
Boiling point	467.6±45.0 °C(Predicted)
Density	1.461±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
pka	4.32±0.50(Predicted)
form	Solid
color	White to Off-White
InChI	InChI=1S/C19H15BrFN/c20-11-16-18(12-7-9-14(21)10-8-12)15-3-1-2-4-17(15)22-19(16)13-5-6-13/h1-4,7-10,13H,5-6,11H2
InChIKey	QCNHMJKMLPPGMF-UHFFFAOYSA-N
SMILES	N1C2C(=CC=CC=2)C(C2=CC=C(F)C=C2)=C(CBr)C=1C1CC1
Comptox DTXSID	DTXSID30652258

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	092060	3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline	154057-56-4	1.00g	$94	2026-05-18	Buy
Matrix Scientific	092060	3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline	154057-56-4	5.00g	$279	2026-05-18	Buy
Synthonix	B59364	3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 95+%	154057-56-4	1g	$20	2026-05-06	Buy
Synthonix	B59364	3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 95+%	154057-56-4	5g	$30	2026-05-06	Buy
Synthonix	B59364	3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 95+%	154057-56-4	25g	$80	2026-05-06	Buy

Product number	Packaging	Price	Buy
092060	1.00g	$94	Buy
092060	5.00g	$279	Buy
B59364	1g	$20	Buy
B59364	5g	$30	Buy
B59364	25g	$80	Buy

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Chemical Properties, Uses, Production

Uses

3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline is used to prepare artificial HMG-CoA reductase inhibitors. It is also used to synthesize pitavastatin calcium via stereoselective Wittig olefination reaction.

Synthesis

1356998-79-2

154057-56-4

Example 17: Preparation of 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline (PTVBR) PTVME (0.85 g, 3.06 mmol) and N-bromosuccinimide (NBS, 1.16 g, 2.1 eq.) were dissolved in a solvent mixture of acetonitrile (MeCN, 20 mL) and carbon tetrachloride (CCl4, 5 mL). The reaction mixture was irradiated for 4 days at room temperature (~20 °C) using light at a wavelength of 254 nm. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residual oil was redissolved in dichloromethane (CH2Cl2, 20 mL). The organic phase was washed sequentially with saturated sodium thiosulfate solution (Na2S2O3, 1 × 10 mL), saturated sodium bicarbonate solution (NaHCO3, 2 × 10 mL), and brine (1 × 10 mL) and dried with anhydrous magnesium sulfate (MgSO4). After removing the solvent under reduced pressure, the product was purified by column chromatography (elution gradient: 1-10% ethyl acetate/n-heptane solution) to give PTVBR (0.22 g, 20% yield). 1H NMR (CDCl3): δ 1.17 (2H, m), 1.40 (2H, m), 2.50-2.54 (1H, m), 4.6 (2H, s), 7.24-7.40 (6H, m), 7.64 (1H, m), 8.00-8.02 (1H, m) ppm. 13C NMR (CDCl3): δ 9.8, 14.7, 29.1, 115.6, 115.8, 125.8, 126.2, 126.4, 127.4, 128.5, 128.8, 129.7, 130.87, 130.91, 131.0, 131.60, 131.63, 146.9, 147.1. 161.4, 161.5, 163.9 ppm.

References

[1] Patent: WO2012/13325, 2012, A1. Location in patent: Page/Page column 65-66
[2] Patent: EP2423195, 2012, A1. Location in patent: Page/Page column 57-58

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Preparation Products And Raw materials

Raw materials

2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde Pitavastatin Impurity 25 Carbon tetrachloride Acetonitrile N-Bromosuccinimide

Preparation Products

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Suppliers

Global Suppliers ( 175)

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Kongfu Pharmaceutical Co	0537-4442222 18854777456	871825068@qq.com	China	15	58
Shandong Meiao Huawei Technology Co., LTD	0531-88682301 18595278766	yuhongmeng@mayowell.com	China	88	58
JIANGXI AIFEIMU TECHNOLOGY CO.,LTD	793-33899567 13735087952	sales@afmpharm.com	China	51	61
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9417	66
Adamas Reagent, Ltd.	4006009262 13023226327	hmj@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6717	52
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57
BioBioPha Co., Ltd.	0871-65217109	y.liu@mail.biobiopha.com	China	5641	65
SynAsst Chemical.	021-60343070		China	12731	55

Supplier	Advantage
Shandong Kongfu Pharmaceutical Co	58
Shandong Meiao Huawei Technology Co., LTD	58
JIANGXI AIFEIMU TECHNOLOGY CO.,LTD	61
Jia Xing Isenchem Co.,Ltd	66
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
XiaoGan ShenYuan ChemPharm co,ltd	52
Tianjin heowns Biochemical Technology Co., Ltd.	57
BioBioPha Co., Ltd.	65
SynAsst Chemical.	55

View Latest Price from 3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-11-06	3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline 154057-56-4		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-26	3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline 154057-56-4		1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2021-07-13	3-(Bromomethyl)-2-cyclopropyl-4-(4"-fluorophenyl)quinoline 154057-56-4	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline
154057-56-4
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline
154057-56-4
98%
Nanjing Fred Technology Co., Ltd

3-(Bromomethyl)-2-cyclopropyl-4-(4"-fluorophenyl)quinoline
154057-56-4
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Spectrum

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline(154057-56-4)¹HNMR

154057-56-4 (3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline) Related Search:

2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid BenzaMide, 2-benzoyl- 2-(4-Fluor-benzoyl)-benzamid PITAVASTATIN LACTONE 2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde

2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Pitavastatin calcium [2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido

Tert-buthyl Pitavastatin tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal (3S,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid CalciuM Salt (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid

(3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid CalciuM Salt (4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester

1of4

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Quinoline,3-(broMoMethyl)-2-cyclopropyl-4-(4-fluoropenyl) 3-(broMoMethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 3-(broMoMethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 2-CYCLOPROPYL-3-(BROMOMETHYL)-4-(4-FLUOROPHENYL)-QUINOLINE 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-MethylBroMide -fluorophenyl)quinoline Pitavastatin Impurity 68 Quinoline, 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)- 3-Hromomcthyy-2-cyclopropyl-4- 4-fluorophenylquinoline 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline? (Pitavastatin Impurity） 3-(Bromomethyl)-2-cyclopropyl-4-(4' Pitavastatin bromide 154057-56-4 intermediate