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3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline structure

CAS No.: 154057-56-4

Chemical Name:: 3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline

Synonyms: 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-MethylBroMide;-fluorophenyl)quinoline;Pitavastatin Impurity 68;3-(Bromomethyl)-2-cyclopropyl-4-(4'3-Hromomcthyy-2-cyclopropyl-4- 4-fluorophenylquinoline;Quinoline,3-(broMoMethyl)-2-cyclopropyl-4-(4-fluoropenyl);3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline;2-CYCLOPROPYL-3-(BROMOMETHYL)-4-(4-FLUOROPHENYL)-QUINOLINE;Quinoline, 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-;3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline? (Pitavastatin Impurity）

CBNumber:: CB02470335

Molecular Formula:: C19H15BrFN

Molecular Weight:: 356.23

MDL Number:: MFCD09031391

MOL File:: 154057-56-4.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:45

Product description	Number	Pack Size	Price
3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline	B687855	1g	$110
3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline	B687855	2.5g	$155
2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methylbromide	X6291	1g	$180
3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 95+%	092060	1g	$94
3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 95+%	092060	5g	$279
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3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Properties

Melting point	131-134°C
Boiling point	467.6±45.0 °C(Predicted)
Density	1.461±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	4.32±0.50(Predicted)
color	White to Off-White
InChI	InChI=1S/C19H15BrFN/c20-11-16-18(12-7-9-14(21)10-8-12)15-3-1-2-4-17(15)22-19(16)13-5-6-13/h1-4,7-10,13H,5-6,11H2
InChIKey	QCNHMJKMLPPGMF-UHFFFAOYSA-N
SMILES	N1C2C(=CC=CC=2)C(C2=CC=C(F)C=C2)=C(CBr)C=1C1CC1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B687855	3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline	154057-56-4	1g	$110	2021-12-16	Buy
TRC	B687855	3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline	154057-56-4	2.5g	$155	2021-12-16	Buy
AK Scientific	X6291	2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methylbromide	154057-56-4	1g	$180	2021-12-16	Buy
Matrix Scientific	092060	3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 95+%	154057-56-4	1g	$94	2021-12-16	Buy
Matrix Scientific	092060	3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 95+%	154057-56-4	5g	$279	2021-12-16	Buy

Product number	Packaging	Price	Buy
B687855	1g	$110	Buy
B687855	2.5g	$155	Buy
X6291	1g	$180	Buy
092060	1g	$94	Buy
092060	5g	$279	Buy

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Chemical Properties,Uses,Production

Uses

3-(Bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline is used to prepare artificial HMG-CoA reductase inhibitors. It is also used to synthesize pitavastatin calcium via stereoselective Wittig olefination reaction.

Synthesis

1356998-79-2

154057-56-4

Example 17: Preparation of 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline (PTVBR) PTVME (0.85 g, 3.06 mmol) and N-bromosuccinimide (NBS, 1.16 g, 2.1 eq.) were dissolved in a solvent mixture of acetonitrile (MeCN, 20 mL) and carbon tetrachloride (CCl4, 5 mL). The reaction mixture was irradiated for 4 days at room temperature (~20 °C) using light at a wavelength of 254 nm. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residual oil was redissolved in dichloromethane (CH2Cl2, 20 mL). The organic phase was washed sequentially with saturated sodium thiosulfate solution (Na2S2O3, 1 × 10 mL), saturated sodium bicarbonate solution (NaHCO3, 2 × 10 mL), and brine (1 × 10 mL) and dried with anhydrous magnesium sulfate (MgSO4). After removing the solvent under reduced pressure, the product was purified by column chromatography (elution gradient: 1-10% ethyl acetate/n-heptane solution) to give PTVBR (0.22 g, 20% yield). 1H NMR (CDCl3): δ 1.17 (2H, m), 1.40 (2H, m), 2.50-2.54 (1H, m), 4.6 (2H, s), 7.24-7.40 (6H, m), 7.64 (1H, m), 8.00-8.02 (1H, m) ppm. 13C NMR (CDCl3): δ 9.8, 14.7, 29.1, 115.6, 115.8, 125.8, 126.2, 126.4, 127.4, 128.5, 128.8, 129.7, 130.87, 130.91, 131.0, 131.60, 131.63, 146.9, 147.1. 161.4, 161.5, 163.9 ppm.

References

[1] Patent: WO2012/13325, 2012, A1. Location in patent: Page/Page column 65-66
[2] Patent: EP2423195, 2012, A1. Location in patent: Page/Page column 57-58

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Preparation Products And Raw materials

Raw materials

2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde Pitavastatin Impurity 25 Carbon tetrachloride Acetonitrile N-Bromosuccinimide

Preparation Products

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Suppliers

Global( 169)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29822	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2949	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Jinan Finer Chemical Co., Ltd	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58

View Lastest Price from 3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-16	3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline 154057-56-4	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-26	3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline 154057-56-4	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2021-07-13	3-(Bromomethyl)-2-cyclopropyl-4-(4"-fluorophenyl)quinoline 154057-56-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline
154057-56-4
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline
154057-56-4
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

3-(Bromomethyl)-2-cyclopropyl-4-(4"-fluorophenyl)quinoline
154057-56-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Spectrum

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline(154057-56-4)¹HNMR

154057-56-4(3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline)Related Search:

BenzaMide, 2-benzoyl- 2-(4-Fluor-benzoyl)-benzamid PITAVASTATIN LACTONE 2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde 2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline

(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-2-propenenitrile 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol Pitavastatin calcium [2-Cyclopropyl-4-(4-fluorophenyl)-quinolin-3-ylmethyl]-triphenyl-phosphonium bromido Tert-buthyl Pitavastatin

tert-Butyl (4R-cis)-6-formaldehydel-2,2-dimethyl-1,3-dioxane-4-acetate (E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal (3S,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid CalciuM Salt (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid (3S,5R,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid CalciuM Salt

(4R,6S)-6-[(1E)-2-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID

1of4

3-(Bromomethyl)-2-cyclopropyl-4-(4'-fluorophenyl)quinoline Quinoline,3-(broMoMethyl)-2-cyclopropyl-4-(4-fluoropenyl) 3-(broMoMethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 3-(broMoMethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline 2-CYCLOPROPYL-3-(BROMOMETHYL)-4-(4-FLUOROPHENYL)-QUINOLINE 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-MethylBroMide -fluorophenyl)quinoline Pitavastatin Impurity 68 Quinoline, 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)- 3-Hromomcthyy-2-cyclopropyl-4- 4-fluorophenylquinoline 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)quinoline? (Pitavastatin Impurity） 3-(Bromomethyl)-2-cyclopropyl-4-(4' 154057-56-4 intermediate