Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
- CAS No.
- 178306-47-3
- Chemical Name:
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
- Synonyms
- ALST-01;Ambrisentan PI-4;2-hydroxy-3-methoxy-3;3-diphenylpropanoic acid methyl ester;Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate;2-Hydroxy-3-methoxy-3,3-diphenylpropanoic acid methyl ester;α-Hydroxy-β-Methoxy-β-phenyl-benzenepropanoic Acid Methyl Ester;Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl e...;Benzenepropanoic acid, α-hydroxy-β-methoxy-β-phenyl-, methyl ester;Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
- CBNumber:
- CB52077328
- Molecular Formula:
- C17H18O4
- Molecular Weight:
- 286.32
- MDL Number:
- MFCD09833706
- MOL File:
- 178306-47-3.mol
- MSDS File:
- SDS
| Melting point | 96-98°C |
|---|---|
| Boiling point | 440.7±40.0 °C(Predicted) |
| Density | 1.176 |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly) |
| form | Solid |
| pka | 12.37±0.20(Predicted) |
| color | White to Off-White |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| HazardClass | IRRITANT |
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 055491 | Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate | 178306-47-3 | 1.00g | $22 | 2026-05-18 | Buy |
| Matrix Scientific | 055491 | Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate | 178306-47-3 | 5.00g | $72 | 2026-05-18 | Buy |
| Matrix Scientific | 055491 | Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate | 178306-47-3 | 25.00g | $238 | 2026-05-18 | Buy |
| Synthonix | M58969 | Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate 97% | 178306-47-3 | 250mg | $60 | 2026-05-06 | Buy |
| Synthonix | M58969 | Methyl 2-hydroxy-3-methoxy-3,3-diphenylpropanoate 97% | 178306-47-3 | 1g | $80 | 2026-05-06 | Buy |
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester Chemical Properties, Uses, Production
Uses
Ambrisentan intermediate.
Synthesis
67-56-1
76527-25-8
178306-47-3
1. 500 g (2.74 mol) of benzophenone was dissolved in 1200 mL of toluene and the reaction system was purged using nitrogen. Subsequently, 267 g (4.94 mol) of sodium methanol was added and stirred to form a suspension. 2. The suspension was cooled and 410 mL (4.68 mol) of methyl chloroacetate in toluene (300 mL) was slowly added dropwise over a period of 90 minutes, with the reaction temperature maintained at -8 to 4°C. The reaction temperature was maintained at -8 to 4°C. After the dropwise addition was completed, the reaction solution was cooled to 0°C and maintained for 1 hr. 3. 1000 mL of water was added and stirred for 15 minutes before liquid-liquid separation. The organic layer was washed with 1000mL of water. 4. The solvent was removed by distillation under reduced pressure and the resulting residue (methyl (RS)-3,3-diphenyl-2,3-epoxyacrylate) was dissolved in 1200 mL of methanol and cooled to 0°C. 5. A methanolic solution of 15 g (0.08 mol) of toluene sulfonic acid monohydrate (150 mL) was added slowly and dropwise over 30 min. The mixture was stirred at 0°C for 1.5 h. The precipitated crystals were collected by filtration. 6. The crystals were dissolved in 2500 mL of ethyl acetate and washed twice with 1000 mL of 5% aqueous sodium carbonate. 7. The solvent was removed by pressurized distillation and 1000 mL of hexane was added to the residue, suspended and stirred at room temperature for 1.5 hours, followed by stirring at 0°C for 1 hour. 8. The crystals were collected by filtration and dried under reduced pressure at 60 °C for 5 h to give 659 g (yield: 84%) of methyl (RS)-2-hydroxy-3-methoxy-3,3-diphenylpropionate.
References
[1] Journal of Medicinal Chemistry, 1996, vol. 39, # 11, p. 2123 - 2128
[2] Patent: JP5700378, 2015, B2. Location in patent: Paragraph 0062
[3] Patent: JP2017/128528, 2017, A. Location in patent: Paragraph 0005; 0039
[4] Patent: WO2012/17441, 2012, A1. Location in patent: Page/Page column 10-11
[5] Patent: WO2010/70658, 2010, A2. Location in patent: Page/Page column 18
Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Kongfu Pharmaceutical Co | 0537-4442222 18854777456 | 871825068@qq.com | China | 15 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Xi'an Manareco New Materials Co., Ltd. | 029-68669089-8800 13087509180; | market@xarlm.com | China | 479 | 55 |
| Tianjin Branch Chong pharmaceutical intermediates Co., Ltd. | 022-60116533 13207668525 | saleskc@scipharmacn.com | China | 360 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Hubei XinyuanShun Chemical Co., Ltd. | 13971561712, 13995564702, 027-50664929 | hbeixys2001@163.com | China | 3110 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid methyl ester
178306-47-3
|
1g | 98%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2025-12-16 | Ambrisentan Impurity
178306-47-3
|
10mg | 95%+ | 100000 | Moxin Chemicals | ||
 |
2021-07-13 | Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
178306-47-3
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-hydroxy-3-methoxy-3,3-diphenylpropanoic acid methyl ester
178306-47-3
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Ambrisentan Impurity
178306-47-3
- 95%+
- Moxin Chemicals
-
- Benzenepropanoic acid,a-hydroxy-b-methoxy-b-phenyl-,methyl ester
178306-47-3
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
