2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
- CAS No.
- 178306-51-9
- Chemical Name:
- 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
- Synonyms
- Ambrisentan PI-2;2-Hydroxy-3-methoxy-3,3-diphenylpropanoicaci;2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID;2-hydroxy-3-methoxy-3,3-diphenyl-propionic acid;Benzenepropanoic acid, α-hydroxy-β-methoxy-β-phenyl-;alpha-Hydroxy-beta-methoxy-beta-phenylbenzenepropanoic acid
- CBNumber:
- CB42468790
- Molecular Formula:
- C16H16O4
- Molecular Weight:
- 272.3
- MDL Number:
- MFCD13152279
- MOL File:
- 178306-51-9.mol
- MSDS File:
- SDS
| Boiling point | 430℃ |
|---|---|
| Density | 1.248 |
| Flash point | 158℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Ethanol (Sparingly, Sonicated), Methanol (Slightly) |
| pka | 3.24±0.28(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C16H16O4/c1-20-16(14(17)15(18)19,12-8-4-2-5-9-12)13-10-6-3-7-11-13/h2-11,14,17H,1H3,(H,18,19) |
| InChIKey | RQJWOLFMWKZKCJ-UHFFFAOYSA-N |
| SMILES | C(O)(C(O)=O)C(OC)(C1=CC=CC=C1)C1C=CC=CC=1 |
| FDA UNII | 4GB74Y4JTK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H335-H301-H319-H312 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501 |
| HazardClass | IRRITANT |
2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H946108 | 2-Hydroxy-3-methoxy-3,3-diphenylpropanoicAcid | 178306-51-9 | 500mg | $80 | 2021-12-16 | Buy |
| TRC | H946108 | 2-Hydroxy-3-methoxy-3,3-diphenylpropanoicAcid | 178306-51-9 | 1g | $130 | 2021-12-16 | Buy |
| TRC | H946108 | 2-Hydroxy-3-methoxy-3,3-diphenylpropanoicAcid | 178306-51-9 | 5g | $400 | 2021-12-16 | Buy |
| TRC | H946108 | 2-Hydroxy-3-methoxy-3,3-diphenylpropanoicAcid | 178306-51-9 | 10g | $690 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | APN0000561 | 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID 95.00% | 178306-51-9 | 10G | $1585.35 | 2021-12-16 | Buy |
2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID Chemical Properties,Uses,Production
Uses
2-Hydroxy-3-methoxy-3,3-diphenylpropanoic Acid is used as a reactant in the preparation of mixed endothelin A and endothelin B selective receptor antagonist (dimethylpyrimidinyloxy)diphenylpropionic acids.
Synthesis
178306-47-3
178306-51-9
General procedure for the synthesis of 2-hydroxy-3-methoxy-3,3-diphenylmethylpropionic acid from methyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate: 500 g (1.75 mol) of (RS)-2-hydroxy-3-methoxy-3,3-diphenylmethylpropionate was suspended in 1,000 mL of water with stirring and 950 mL (1.90 mol) of 2 mol/L sodium hydroxide solution. The reaction mixture was stirred at 100°C for 1 hour. Upon completion of the reaction, the solution was cooled to room temperature and 1,500 mL of tert-butyl methyl ether was added followed by 700 mL of 10% hydrochloric acid and stirred for 20 minutes to dissolve the precipitated solids. After performing a liquid-liquid separation, the organic layer was washed with 1,000 mL of water. To the organic layer, 1,200 mL of heptane was added and the solvent was removed by distillation under reduced pressure at 40 °C and 200 mmHg pressure to induce precipitation of crystals. Another 1,000 mL of heptane was added and the mixture was stirred at 0 °C for 1 hour. The crystals were collected by filtration and dried under reduced pressure at 40 °C for 7 h to give 431 g (91% yield) of (RS)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid.
References
[1] Patent: JP2017/128528, 2017, A. Location in patent: Paragraph 0005; 0040
[2] Patent: WO2012/17441, 2012, A1. Location in patent: Page/Page column 11
[3] Patent: WO2010/70658, 2010, A2. Location in patent: Page/Page column 18-19
[4] Patent: US2011/263854, 2011, A1. Location in patent: Page/Page column 8
[5] Organic Process Research and Development, 2001, vol. 5, # 1, p. 16 - 22
2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8826 | 58 |
| Chengdu Aslee Biopharmaceuticals, Inc. | 28-85305008 | CHINA | 964 | 58 | |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; | info@fortunachem.com | China | 5987 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9236 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
View Lastest Price from 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-29 | 2-hydroxy-3-Methoxy-3,3-diphenylpropanoic acid
178306-51-9
|
US $0.00 / g | 1g | 98%min | 1000g | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-07-31 | Ambrisentan Impurity 5
178306-51-9
|
US $0.00-0.00 / mg | 10mg | 95%+ | 100000 | Moxin Chemicals | |
 |
2021-07-13 | 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
178306-51-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-hydroxy-3-Methoxy-3,3-diphenylpropanoic acid
178306-51-9
- US $0.00 / g
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Ambrisentan Impurity 5
178306-51-9
- US $0.00-0.00 / mg
- 95%+
- Moxin Chemicals
-
- 2-HYDROXY-3-METHOXY-3,3-DIPHENYLPROPANOIC ACID
178306-51-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
