ChemicalBook >> CAS DataBase List >>1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
- CAS No.
- 137977-97-0
- Chemical Name:
- 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
- Synonyms
- 1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 39;Tolvaptan Impurity 10;Histaprodifen Impurity 1;Tolvaptan Intermediate 3;1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1...;1-(4-amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-2H-1-benzazepin-5-one;1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one;1-(4-aMino-2-Methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;7-Chloro-5-oxo-1-(2-methyl-4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine
- CBNumber:
- CB02500621
- Molecular Formula:
- C18H17ClN2O2
- Molecular Weight:
- 328.79
- MDL Number:
- MFCD19440799
- MOL File:
- 137977-97-0.mol
- MSDS File:
- SDS
Last updated:2026-08-05 19:35:02
| Melting point | 186-189°C |
|---|---|
| Boiling point | 565.4±50.0 °C(Predicted) |
| Density | 1.320 |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 2.28±0.10(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| InChI | InChI=1S/C18H17ClN2O2/c1-11-9-13(20)5-6-14(11)18(23)21-8-2-3-17(22)15-10-12(19)4-7-16(15)21/h4-7,9-10H,2-3,8,20H2,1H3 |
| InChIKey | FLJCJPKXJWRZJB-UHFFFAOYSA-N |
| SMILES | N1(C(=O)C2=CC=C(N)C=C2C)C2=CC=C(Cl)C=C2C(=O)CCC1 |
| FDA UNII | ZQM32LG67U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P280 |
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-T296000-5G | 1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one | 137977-97-0 | 5g | $1559 | 2026-06-03 | Buy |
| TRC | TRC-T296000-1G | 1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one | 137977-97-0 | 1g | $860 | 2026-06-03 | Buy |
| TRC | TRC-T296000-100MG | 1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one | 137977-97-0 | 100mg | $154 | 2026-06-03 | Buy |
| Synthonix | A37727 | 1-(4-Amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 90+% | 137977-97-0 | 250mg | $24 | 2026-05-06 | Buy |
| Synthonix | A37727 | 1-(4-Amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 90+% | 137977-97-0 | 1g | $50 | 2026-05-06 | Buy |
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Chemical Properties, Uses, Production
Uses
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one is an intermediate used in the synthetic preparation of Tolvaptan (T536650), a selective nonpeptide arginine vasopressin V 2 receptor antagonist.
Uses
1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one is an intermediate used in the synthetic preparation of Tolvaptan (T536650), a selective nonpeptide arginine vasopressin V2 receptor antagonist.
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 165)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Enki Biopharmaceuticals(Shanghai) Limited | +86-21 5768 0965 +86-13916707528 | yusu@enkibiopharma.com | China | 47 | 55 |
| Jiangxi Jinfeng Pharmaceutical Co., Ltd | 793-5181188 18170363299 | yangyuening@jxjfpharma.com | China | 62 | 58 |
| Suzhou Junye Biopharmaceutical Technology Co., Ltd | 0512-0512-53662086-8001 18913766772 | wangli@jyk-biotech.cn | China | 489 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Hangzhou Minsuo Technology Co., Ltd. | 571-88199336 18957129209 | 309645123@qq.com | China | 55 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6740 | 52 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Taizhou Tongxin Bio-Tech Co., Ltd | 0523-86818997 18652728585 | sales@allyrise.com | China | 2987 | 60 |
View Latest Price from 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
137977-97-0
|
1KG | 99%min | 1000KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-18 | 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
137977-97-0
|
1G | 99% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2026-09-10 | 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
137977-97-0
|
1kg | 99.0% | 5000 | Enki Biopharmaceuticals (Shanghai) Limited |
-
- 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
137977-97-0
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
137977-97-0
- 99%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
137977-97-0
- 99.0%
- Enki Biopharmaceuticals (Shanghai) Limited
137977-97-0 (1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one) Related Search:
Tolvaptan Impurity 11
Tolvaptan Impurity 26
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
5-Dehydro Tolvaptan
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
Tolvaptan Impurity 3 (DM-4104)
Tolvaptan Impurity 30
7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one
2-Methyl-4-nitrobenzoic acid
Tolvaptan Impurity 4 (DM-4105)
1of4
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one
5H-1-Benzazepin-5-one, 1-(4-aMino-2-Methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-
1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one
Tolvaptan Impurity 10
1-(4-aMino-2-Methylbenzoyl)-7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
1-(4-Amino-2-Methylbenzoyl)-7-Chloro-1,2,3,4-Tetrahydro-5H-1-benzazepine-5-One
1-(4-amino-2-methylbenzoyl)-7-chloro-3,4-dihydro-2H-1-benzazepin-5-one
Tolvaptan Intermediate 3
1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1...
1-(4- amino -2- methylbenzoyl) -7- chloro -1,2,3,4- tetrahydro -5H-1- benzoazepine -5- one *
Tovaptan impurity 39
7-Chloro-5-oxo-1-(2-methyl-4-aminobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine
Histaprodifen Impurity 1
1-(4-amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one
137977-97-0
Pharmaceutical Intermediates
137977-97-0
