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ChemicalBook >> CAS DataBase List >>7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Structure
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one structure
CAS No.
137982-91-3
Chemical Name:
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
Synonyms
7-chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;1H-benzo[b]azepine;Tovaptan impurity 12;Tovaptan impurity 32;Tolvaptan Impurity 12;Tolvaptan InterMediates;7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1...;7-chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-2H-1-benzazepin-5-one;7-chloro-1-(2-Methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one;7-Chloro-5-oxo-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine
CBNumber:
CB32500622
Molecular Formula:
C18H15ClN2O4
Molecular Weight:
358.78
MDL Number:
MFCD19440800
MOL File:
137982-91-3.mol
MSDS File:
SDS
Last updated:2026-05-28 01:05:04
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7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Properties

Melting point 152 - 155°C
Boiling point 573.3±50.0 °C(Predicted)
Density 1.387
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka -2.58±0.20(Predicted)
color White to Off-White
InChI InChI=1S/C18H15ClN2O4/c1-11-9-13(21(24)25)5-6-14(11)18(23)20-8-2-3-17(22)15-10-12(19)4-7-16(15)20/h4-7,9-10H,2-3,8H2,1H3
InChIKey NNCRQBJNAGEBDM-UHFFFAOYSA-N
SMILES N1(C(=O)C2=CC=C([N+]([O-])=O)C=C2C)C2=CC=C(Cl)C=C2C(=O)CCC1
FDA UNII EWB5QJ6P82

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-C366123-50MG 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 137982-91-3 50mg $607 2026-06-03 Buy
TRC TRC-C366123-250MG 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 137982-91-3 250mg $2621 2026-06-03 Buy
TRC TRC-C366123-100MG 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 137982-91-3 100mg $1175 2026-06-03 Buy
aablocks AA0017P5 7-Chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 98% 137982-91-3 1g $27 2026-05-28 Buy
aablocks AA0017P5 7-Chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 98%HPLC 137982-91-3 5g $46 2026-05-28 Buy
Product number Packaging Price Buy
TRC-C366123-50MG 50mg $607 Buy
TRC-C366123-250MG 250mg $2621 Buy
TRC-C366123-100MG 100mg $1175 Buy
AA0017P5 1g $27 Buy
AA0017P5 5g $46 Buy

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Chemical Properties, Uses, Production

Uses

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one is an intermediate in synthesizing Tolvaptan-d7 (T536652), a labelled Tolvaptan (T536650). It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Preparation Products And Raw materials

Raw materials

Preparation Products

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Suppliers

Global Suppliers ( 133)
Supplier Tel Email Country ProdList Advantage
Enki Biopharmaceuticals(Shanghai) Limited +86-21 5768 0965 +86-13916707528 yusu@enkibiopharma.com China 47 55
Jiangxi Jinfeng Pharmaceutical Co., Ltd 793-5181188 18170363299 yangyuening@jxjfpharma.com China 62 58
Suzhou Junye Biopharmaceutical Technology Co., Ltd 0512-0512-53662086-8001 18913766772 wangli@jyk-biotech.cn China 489 58
Shanghai Peiling Biological Technology Co., LTD 13127581762 13127581762 peilingchem@sina.com China 494 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16306 64
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6740 52
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
Ascepion Pharmaceuticals, Inc. +86-512-86881668 China 100 58
Supplier Advantage
Enki Biopharmaceuticals(Shanghai) Limited 55
Jiangxi Jinfeng Pharmaceutical Co., Ltd 58
Suzhou Junye Biopharmaceutical Technology Co., Ltd 58
Shanghai Peiling Biological Technology Co., LTD 58
Chembest Research Laboratories Limited 61
Nanjing Chemlin Chemical Co., Ltd 64
XiaoGan ShenYuan ChemPharm co,ltd 52
Nanjing Vital Chemical Co., Ltd. 65
Beijing HuaMeiHuLiBiological Chemical 58
Ascepion Pharmaceuticals, Inc. 58

View Latest Price from 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one pictures 2026-09-18 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one
137982-91-3
 1KG 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.
7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5h-1-benzazepin-5-one pictures 2026-09-10 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5h-1-benzazepin-5-one
137982-91-3
 1kg 99.0% 20000 Enki Biopharmaceuticals (Shanghai) Limited
7-Chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one pictures 2026-03-12 7-Chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one
137982-91-3
 10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD

137982-91-3 (7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one) Related Search:

Ethyl 7-Chloro-5-oxo-1-toxyl-2,3,4,5,-tetrahydro-1H-benzo[b]azepine-4-carboxylate Tolvaptan Impurity 18 Tolvaptan Impurity 13 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester Tolvaptan Impurity 21
Tolvaptan Impurity 3 (DM-4104) Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17 Tolvaptan impurity 2
Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26 Tolvaptan
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 5-Dehydro Tolvaptan 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one

1of4

7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one Tolvaptan InterMediates 7-chloro-1-(2-Methyl-4-nitrobenzoyl)-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one 1H-benzo[b]azepine 7-Chloro-1,2,3,4-Tetrahydro-1-(2-Methyl-4-Nitrobenzoyl)-5H-1-Benzazepine-5-One Tolvaptan Impurity 12 7-chloro-1-(2-methyl-4-nitrobenzoyl)-3,4-dihydro-2H-1-benzazepin-5-one 5H-1-Benzazepin-5-one, 7-chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)- 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one CAS 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1... 7- chloro -1,2,3,4- tetrahydro -1-(2- methyl -4- nitrobenzoyl) -5H-1- benzoazepine -5- one * Tovaptan impurity 12 Tovaptan impurity 32 7-chloro-1-(2-methyl-4-(2-methylbenzamido)benzoyl)-2,3-dihydro-1H-benzo[b]azepin-5-yl 2-methylbenzoate 7-Chloro-5-oxo-1-(2-methyl-4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-benzazepine 7-chloro-1 -(2-methyl-4-nitrobenzoyl)-3, 4-dihydro-1h-benzo [b] azepine-5 (2H) -ketone 7-chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 7-Chloro-1-(2-methyl-4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 137982-91-3 Pharmaceutical Intermediates