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ChemicalBook >> CAS DataBase List >>7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Structure
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one structure
CAS No.
160129-45-3
Chemical Name:
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one
Synonyms
7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE;7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine;Tovaptan impurity 29;Tovaptan impurity 24;Tolvaptan Impurity 29;7-chloro-2,3,4,5-tetrahydro-;7-Chlorobenzo[b]azepan-5-one;Linagliptin Impurity CD10143;7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one
CBNumber:
CB7477186
Molecular Formula:
C10H10ClNO
Molecular Weight:
195.65
MDL Number:
MFCD06738694
MOL File:
160129-45-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:14:48
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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Properties

Melting point 103.0 to 107.0 °C
Boiling point 356.5±41.0 °C(Predicted)
Density 1.234±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 2.36±0.20(Predicted)
color Off-White to Pale Yellow
InChI InChI=1S/C10H10ClNO/c11-7-3-4-9-8(6-7)10(13)2-1-5-12-9/h3-4,6,12H,1-2,5H2
InChIKey AHESNFIUAHTYGS-UHFFFAOYSA-N
SMILES N1C2=CC=C(Cl)C=C2C(=O)CCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes  T
Risk Statements  25
Safety Statements  45
HS Code  2933998090

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C2896 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one >98.0%(GC)(T) 160129-45-3 1g $86 2026-04-30 Buy
TCI Chemical C2896 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one >98.0%(GC)(T) 160129-45-3 5g $343 2026-04-30 Buy
TRC TRC-C366265-25G 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one 160129-45-3 25g $1100 2026-06-03 Buy
TRC TRC-C366265-1G 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one 160129-45-3 1g $179 2026-06-03 Buy
TRC TRC-C366265-10G 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one 160129-45-3 10g $561 2026-06-03 Buy
Product number Packaging Price Buy
C2896 1g $86 Buy
C2896 5g $343 Buy
TRC-C366265-25G 25g $1100 Buy
TRC-C366265-1G 1g $179 Buy
TRC-C366265-10G 10g $561 Buy

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Chemical Properties, Uses, Production

Chemical Properties

White Solid

Uses

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of Tolvaptan (T536650) (OPC-41061), an orally active nonpeptide arginine vasopressin V2 receptor antagonist

Synthesis

The synthetic method of 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one comprises the following steps: carrying out an acylation reaction between 4-chloroaniline and succinic anhydride to obtain 4-(4-chloroaniline)-4-oxobutyric acid; carrying out an intramolecular Friedel-Craft reaction on 4-(4-chloroaniline)-4-oxobutyric acid to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one; reacting 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one with ethylene glycol to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal; reducing 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal, and carrying out de-ketalation under an acidic condition to obtain 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one.

References

[1] Patent: WO2007/26971, 2007, A2. Location in patent: Page/Page column 28
[2] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 8, p. 1743 - 1754
[3] Tetrahedron Asymmetry, 2010, vol. 21, # 19, p. 2390 - 2393

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Preparation Products And Raw materials

Raw materials

7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Sodium hydroxide Sulfuric acid

Preparation Products

5-Dehydro Tolvaptan

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Suppliers

Global Suppliers ( 312)
Supplier Tel Email Country ProdList Advantage
Jiangxi Jinfeng Pharmaceutical Co., Ltd 793-5181188 18170363299 yangyuening@jxjfpharma.com China 62 58
Sinfachem Limited. 025-84683399 13952017251 sinfachem@foxmail.com China 267 58
Enki Biopharmaceuticals(Shanghai) Limited +86-21 5768 0965 +86-13916707528 yusu@enkibiopharma.com China 47 55
Zhenjiang Carbochem Pharmatech Co.,LTD 0511-81886918 18136818960 sales4@carbo-chem.com China 357 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Supplier Advantage
Jiangxi Jinfeng Pharmaceutical Co., Ltd 58
Sinfachem Limited. 58
Enki Biopharmaceuticals(Shanghai) Limited 55
Zhenjiang Carbochem Pharmatech Co.,LTD 58
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Jia Xing Isenchem Co.,Ltd 66
Adamas Reagent, Ltd. 59

View Latest Price from 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one pictures 2026-09-10 7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one
160129-45-3
 25kg 99.0% 10000 Enki Biopharmaceuticals (Shanghai) Limited
Tolvaptan Impurity 9 pictures 2026-03-12 Tolvaptan Impurity 9
160129-45-3
 10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD
7-chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one pictures 2025-07-07 7-chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one
160129-45-3
 100kg ≥99.0% 20 tons HEBEI BRANT PHARMACEUTICAL CO.,LTD

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Spectrum

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one(160129-45-3)1HNMR

160129-45-3 (7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one) Related Search:

6-Chloro-1H-benzimidazole 2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17
Tolvaptan impurity 2 Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26
6-Chloro-2-benzoxazolethiol 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one
7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 2,3,4,5-Tetrahydro-1H-benzo[b]azepine 7-Chloro-9-methoxy-1,2,3,4-tetrahydro-benzo[b]azepin-5-one

1of4

7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one Tolvaptan Impurity 29 5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro- 7-Chlorobenzo[b]azepan-5-one 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE 7-chloro-2,3,4,5-tetrahydro- 7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one > 7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ones Tovaptan impurity 29 Tovaptan impurity 24 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepine-5-One Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one Linagliptin Impurity CD10143 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine 7-Chloro-1,2,3,4-tetrahydro-5H-1- benzozepin-5-one Tolvapatan Int 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 160129-45-3 61120-92-3 Building Blocks/Intermediates Tolvaptan intermediate