ChemicalBook >> CAS DataBase List >>7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one structure

CAS No.: 160129-45-3

Chemical Name:: 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one

Synonyms: 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one;Tovaptan impurity 29;Tovaptan impurity 24;Tolvaptan Impurity 29;7-Chlorobenzo[b]azepan-5-one;7-chloro-2,3,4,5-tetrahydro-;Linagliptin Impurity CD10143;7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one;7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one;7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone

CBNumber:: CB7477186

Molecular Formula:: C10H10ClNO

Molecular Weight:: 195.65

MDL Number:: MFCD06738694

MOL File:: 160129-45-3.mol

MSDS File:: SDS

Last updated:2025-07-24 18:11:56

Product description	Number	Pack Size	Price
7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one >98.0%(GC)(T)	C2896	1g	$86
7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one >98.0%(GC)(T)	C2896	5g	$343
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one	C366265	10g	$415
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one	162272	1g	$418
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one	FC51283	100g	$500
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7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Properties

Melting point	103.0 to 107.0 °C
Boiling point	356.5±41.0 °C(Predicted)
Density	1.234±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	2.36±0.20(Predicted)
color	Off-White to Pale Yellow
InChI	InChI=1S/C10H10ClNO/c11-7-3-4-9-8(6-7)10(13)2-1-5-12-9/h3-4,6,12H,1-2,5H2
InChIKey	AHESNFIUAHTYGS-UHFFFAOYSA-N
SMILES	N1C2=CC=C(Cl)C=C2C(=O)CCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard Codes	T
Risk Statements	25
Safety Statements	45
HS Code	2933998090

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C2896	7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one >98.0%(GC)(T)	160129-45-3	1g	$86	2026-03-19	Buy
TCI Chemical	C2896	7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one >98.0%(GC)(T)	160129-45-3	5g	$343	2026-03-19	Buy
TRC	C366265	7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one	160129-45-3	10g	$415	2021-12-16	Buy
Usbiological	162272	7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one	160129-45-3	1g	$418	2021-12-16	Buy
Biosynth Carbosynth	FC51283	7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one	160129-45-3	100g	$500	2021-12-16	Buy

Product number	Packaging	Price	Buy
C2896	1g	$86	Buy
C2896	5g	$343	Buy
C366265	10g	$415	Buy
162272	1g	$418	Buy
FC51283	100g	$500	Buy

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of Tolvaptan (T536650) (OPC-41061), an orally active nonpeptide arginine vasopressin V2 receptor antagonist

Synthesis

The synthetic method of 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one comprises the following steps: carrying out an acylation reaction between 4-chloroaniline and succinic anhydride to obtain 4-(4-chloroaniline)-4-oxobutyric acid; carrying out an intramolecular Friedel-Craft reaction on 4-(4-chloroaniline)-4-oxobutyric acid to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one; reacting 7-chloro-3,4-tetrahydrobenzo[b]azepine-2,5-one with ethylene glycol to obtain 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal; reducing 7-chloro-3,4-tetrahydrobenzo[b]azepine-2-one-5-glycol ketal, and carrying out de-ketalation under an acidic condition to obtain 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one.

References

[1] Patent: WO2007/26971, 2007, A2. Location in patent: Page/Page column 28
[2] Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 8, p. 1743 - 1754
[3] Tetrahedron Asymmetry, 2010, vol. 21, # 19, p. 2390 - 2393

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Preparation Products And Raw materials

Raw materials

7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Sodium hydroxide Sulfuric acid

Preparation Products

5-Dehydro Tolvaptan

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Suppliers

Global( 297)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Enki Biopharmaceuticals (Shanghai) Limited	+86-0086-2157680326 +8613916707528	yusu@enkibiopharma.com	China	53	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29825	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2972	58
Jinan Finer Chemical Co., Ltd	+86-531-88989536 +86-15508631887	sales@finerchem.com	China	2951	58
Cangzhou Wanyou New Material Technology Co.,Ltd	18631714998	sales@czwytech.com	CHINA	904	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shanghai Jinghao Pharmaceutical Co.,Ltd	+86-21-68900963	sales@jinghaopharma.com	CHINA	153	58

Supplier	Advantage
Enki Biopharmaceuticals (Shanghai) Limited	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Jinan Finer Chemical Co., Ltd	58
Cangzhou Wanyou New Material Technology Co.,Ltd	58
Alchem Pharmtech,Inc.	58
Shanghai Jinghao Pharmaceutical Co.,Ltd	58

View Lastest Price from 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-09	7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one 160129-45-3	US $0.00 / kg	25kg	99.0%	10000	Enki Biopharmaceuticals (Shanghai) Limited
2026-03-12	Tolvaptan Impurity 9 160129-45-3	US $0.00-0.00 / mg	10mg	98%	500mg	ShenZhen H&D Pharmaceutical Technology Co., LTD
2025-07-07	7-chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one 160129-45-3	US $0.00-0.00 / kg	100kg	≥99.0%	20 tons	HEBEI BRANT PHARMACEUTICAL CO.,LTD

7-Chloro-1，2，3，4-tetrahydrobenzo(b)azepin-5-one
160129-45-3
US $0.00 / kg
99.0%
Enki Biopharmaceuticals (Shanghai) Limited

Tolvaptan Impurity 9
160129-45-3
US $0.00-0.00 / mg
98%
ShenZhen H&D Pharmaceutical Technology Co., LTD

7-chloro-1,2,3,4-tetrahydro-benzo[b]azepin-5-one
160129-45-3
US $0.00-0.00 / kg
≥99.0%
HEBEI BRANT PHARMACEUTICAL CO.,LTD

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one Spectrum

7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one(160129-45-3)¹HNMR

160129-45-3(7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one)Related Search:

2-Methyl-4-nitrobenzoic acid Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17 Tolvaptan impurity 2

Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26 6-CHLORO-1H-BENZIMIDAZOLE

6-Chloro-2-benzoxazolethiol 5-Dehydro Tolvaptan 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one 1-(4-Amino-2-methylbenzoyl)-7-chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one

2,3,4,5-Tetrahydro-1H-benzo[b]azepine 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 7-CHLORO-9-METHOXY-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

1of4

7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one 7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one Tolvaptan Impurity 29 5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro- 7-Chlorobenzo[b]azepan-5-one 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one 7-CHLORO-1,2,3,4-TERTRAHYDROBENZO(B) AZEPIN-5-ONE 7-chloro-2,3,4,5-tetrahydro- 7-chloro-1,2,3,4-tetrahydrobenzo [b] aza-5-one 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one > 7-chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-ones Tovaptan impurity 29 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine Tovaptan impurity 24 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepine-5-One Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one Linagliptin Impurity CD10143 7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine 7-Chloro-1,2,3,4-tetrahydro-5H-1- benzozepin-5-one Tolvapatan Int 7-chloro-1,2,3,4-tetrahydro-5H-benzo[b]azepin-5-one 160129-45-3 61120-92-3 Building Blocks/Intermediates Tolvaptan intermediate