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4-Amino-2-hydroxy-5-methylpyridine

4-Amino-2-hydroxy-5-methylpyridine structure

CAS No.: 95306-64-2

Chemical Name:: 4-Amino-2-hydroxy-5-methylpyridine

Synonyms: 4-AMino-5-Methylpyridin-2(1H)-one;4-amino-5-methyl-1H-pyridin-2-one;4-AMino-5-Methylpyridin-2-ol;Finerenone Impurity A;Finerenone intermediate;4-amino-5-methylpyridone;4-Amino-5-methylpyridine-2-ol;4-Amino-2-hydroxy-5-methylpyridine;4-amino-5-methyl-1,2-dihydropyridin-2-one;Degarelix Impurity 4

CBNumber:: CB02507291

Molecular Formula:: C6H8N2O

Molecular Weight:: 124.14

MDL Number:: MFCD12546373

MOL File:: 95306-64-2.mol

MSDS File:: SDS

Last updated:2026-05-27 17:25:27

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4-Amino-2-hydroxy-5-methylpyridine Properties

Boiling point	291.0±33.0℃ (760 Torr)
Density	1.137±0.06 g/cm3 (20 ºC 760 Torr)
vapor pressure	0-0Pa at 20-50℃
Flash point	129.8±25.4℃
storage temp.	2-8°C(protect from light)
pka	11.90±0.10(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C6H8N2O/c1-4-3-8-6(9)2-5(4)7/h2-3H,1H3,(H3,7,8,9)
InChIKey	SSQZBQXJYGNUSC-UHFFFAOYSA-N
SMILES	C1(=O)NC=C(C)C(N)=C1
LogP	-0.51 at 20℃ and pH6.3
CAS DataBase Reference	95306-64-2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
REACH Registrations	Active

4-Amino-2-hydroxy-5-methylpyridine price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FA16237	4-Amino-5-methyl-2(1H)-pyridinone	95306-64-2	0.002kg	$150	2026-06-04	Buy
Biosynth	FA16237	4-Amino-5-methyl-2(1H)-pyridinone	95306-64-2	0.001kg	$150	2026-06-04	Buy
Biosynth	FA16237	4-Amino-5-methyl-2(1H)-pyridinone	95306-64-2	0.005kg	$226.75	2026-06-04	Buy
Biosynth	FA16237	4-Amino-5-methyl-2(1H)-pyridinone	95306-64-2	0.01kg	$362.8	2026-06-04	Buy
Activate Scientific	AS42316	4-Amino-5-methylpyridin-2-ol 98%	95306-64-2	1g	$23	2026-06-04	Buy

Product number	Packaging	Price	Buy
FA16237	0.002kg	$150	Buy
FA16237	0.001kg	$150	Buy
FA16237	0.005kg	$226.75	Buy
FA16237	0.01kg	$362.8	Buy
AS42316	1g	$23	Buy

4-Amino-2-hydroxy-5-methylpyridine Chemical Properties, Uses, Production

Description

4-Amino-2-hydroxy-5-methylpyridine belongs to the pyridine derivatives and is significantly alkaline. Its alcoholic hydroxyl group can undergo corresponding nucleophilic substitution reactions under alkaline conditions. It can be used as a material in organic synthesis and medicinal chemistry. The intermediate is used for the modification and production of drug molecules.

Chemical Properties

4-Amino-5-methyl-2-hydroxypyridine is insoluble in water and soluble in strong polar organic solvents. It has an amino group in its structure and therefore exhibits significant basicity. The carbonyl group in the structure can be considered to exist in an enolic form, and its alcoholic hydroxyl group can undergo the corresponding nucleophilic substitution reaction under basic conditions.

Uses

4-Amino-2-hydroxy-5-methylpyridine has been used as a reactant for the synthesis of finerenone, a selective mineralocorticoid receptor (MR) antagonist to be used to lower the risk of severe kidney and heart problems.

Synthesis

4-Amino-2-hydroxy-5-methylpyridine, dissolved in ethylene glycol, could be a starting material to synthesize 4-AMino-5-Methylpyridin-2-ol. The crude product could be precipitated by adding hydrochloric acid/methanol solution.

4-Amino-2-hydroxy-5-methylpyridine synthesis

Synthesis of 4-Amino-2-hydroxy-5-methylpyridine from 2-chloro-5-methylpyridin-4-amine

4-Amino-2-hydroxy-5-methylpyridine Preparation Products And Raw materials

Raw materials

2-chloro-5-methylpyridin-4-amine 2(1H)-Pyridinone,4-hydroxy-5-methyl-(9CI)

Preparation Products

4-Amino-2-hydroxy-5-methylpyridine Suppliers

Global Suppliers ( 338)

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan XuanDe Chemical Co., Ltd.	0531-88803958 19862127196	zhangxu@shiningpharm.com	China	202	58
Hangzhou Chemtrue Bio-Tech Co.,Ltd.	19967494293	sales@chemtrue-bio.com	China	303	58
Hangzhou Cheminspire Technology Co., Ltd.	0571-89081561; 10006559855	info@cheminspire.com	China	412	58
Shandong Sihuan Pharmaceutical Co., Ltd.	0531-88993893 13335127975	fairouz@sdsihuanpharm.com	China	79	58
Shandong Xuanshuo Pharmaceutical Technology Co. LTD	15269103900	suchangzhou@shiningpharm.com	China	384	58
Nanjing Vcare PharmaTech Co., Ltd	025-58741518 13327700685	sales@vcarepharmatech.com	China	483	58
Shanghai Arbor Chemical Co., Ltd.	021-60451683 15021268886	sales@arborchemical.com	China	837	55
ZHUHAI HRD PHARMACEUTICAL CO., LTD.	7737188 13326687259	sales@hrdpharm.com	China	141	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55

Supplier	Advantage
Jinan XuanDe Chemical Co., Ltd.	58
Hangzhou Chemtrue Bio-Tech Co.,Ltd.	58
Hangzhou Cheminspire Technology Co., Ltd.	58
Shandong Sihuan Pharmaceutical Co., Ltd.	58
Shandong Xuanshuo Pharmaceutical Technology Co. LTD	58
Nanjing Vcare PharmaTech Co., Ltd	58
Shanghai Arbor Chemical Co., Ltd.	55
ZHUHAI HRD PHARMACEUTICAL CO., LTD.	58
J & K SCIENTIFIC LTD.	76
Beijing HwrkChemical Technology Co., Ltd	55

View Latest Price from 4-Amino-2-hydroxy-5-methylpyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-16	4-Amino-2-hydroxy-5-methylpyridine 95306-64-2		100gm	99%min	100kgs	Shanghai Yongzeng Technology Co.,Ltd
2026-09-03	4-Amino-2-hydroxy-5-methylpyridine 95306-64-2		1kg	≥98% by HPLC	100kg/month	Zison Pharmaceutical (Shandong) Co., Ltd.
2026-09-02	4-AMino-5-Methylpyridin-2(1H)-one 95306-64-2	$3.00-10.00	1kg	99%		Henan Fengda Chemical Co., Ltd

4-Amino-2-hydroxy-5-methylpyridine
95306-64-2
$0.00
99%min
Shanghai Yongzeng Technology Co.,Ltd

4-Amino-2-hydroxy-5-methylpyridine
95306-64-2
≥98% by HPLC
Zison Pharmaceutical (Shandong) Co., Ltd.

4-AMino-5-Methylpyridin-2(1H)-one
95306-64-2
$3.00-10.00
99%
Henan Fengda Chemical Co., Ltd

4-Amino-2-hydroxy-5-methylpyridine Spectrum

4-Amino-2-hydroxy-5-methylpyridine(95306-64-2)¹HNMR

95306-64-2 (4-Amino-2-hydroxy-5-methylpyridine) Related Search:

4-AMino-5-benzyl-pyriMidine-2-thiol 5-Methyl-4-nitropyridin-2(1H)-one 4-Amino-pyridin-2-ol 3-Pyridinecarbonitrile, 4-amino-1,6-dihydro-6-oxo- 2(1H)-Pyridinone,4-amino-5-ethyl-(9CI)

2(1H)-Pyridinone, 4-amino-5-(difluoromethyl)-

1of2

4-amino-5-methylpyridine-2(1H)-one 4-Amino-2-hydroxy-5-methylpyridine 4-AMino-5-Methyl-2-(1H)-pyridinone 2(1H)-Pyridinone, 4-amino-5-methyl- Finerenone Impurity 28 4-Amino-5-methyl-2-hydroxypyridine 4-amino-5-methylpyridine-2(1H)-on 4-Amino-5-methyl-2(1H)-pyridinone (4-Amino-5-methyl-2-pyridinol) 4-AMino-5-Methylpyridin-2Chemicalbook(1H)-one Degarelix Impurity 4 Felodipine Impurity 14 4-Amino-5-Methylpyridin-2(1H)-One 4--5--2- 2-Hydroxy-4-Amino-5-Methyl pyridine 4-amino-5-methyl-1H-pyridin-2-one 4-AMino-5-Methylpyridin-2(1H)-one 4-Amino-5-methylpyridine-2-ol 4-amino-5-methyl-1,2-dihydropyridin-2-one 4-amino-5-methylpyridone 4-AMino-5-Methylpyridin-2-ol Finerenone intermediate Finerenone Impurity A 95306-64-2 Intermediate 95306-64-2