Tramadol hydrochloride
- CAS No.
- 36282-47-0
- Chemical Name:
- Tramadol hydrochloride
- Synonyms
- Contramal;Tadol;Tramadol hydrocloride;Radol;Zydol;Adamon;Dolana;Mabron;Trabar;Tradol
- CBNumber:
- CB0251095
- Molecular Formula:
- C16H25NO2.ClH
- Molecular Weight:
- 299.84
- MDL Number:
- MFCD00798507
- MOL File:
- 36282-47-0.mol
- MSDS File:
- SDS
| Melting point | 178-181 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Freely soluble in water and in methanol, very slightly soluble in acetone. |
| form | solid |
| pka | 9.41 |
| color | white to off-white |
| InChI | 1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m1./s1 |
| InChIKey | PPKXEPBICJTCRU-XMZRARIVSA-N |
| SMILES | Cl.COc1cccc(c1)[C@@]2(O)CCCC[C@@H]2CN(C)C |
| NCI Dictionary of Cancer Terms | Ultram |
| FDA UNII | 9N7R477WCK |
| NCI Drug Dictionary | Ultram |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H411 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| target organs | Central nervous system |
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn,N |
| Risk Statements | 22-51/53 |
| Safety Statements | 61 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 2 |
| HS Code | 2922504500 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 2 STOT SE 3 |
| Toxicity | mouse,LD50,intravenous,61700ug/kg (61.7mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 114, 1978. |
Tramadol hydrochloride price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR8812 | Tramadol hydrochloride pharmaceutical secondary standard, certified reference material | 36282-47-0 | 200MG | $294 | 2026-04-30 | Buy |
| Sigma-Aldrich | BP744 | Tramadol hydrochloride British Pharmacopoeia (BP) Reference Standard | 36282-47-0 | 100MG | $256 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1672600 | Tramadol hydrochloride United States Pharmacopeia (USP) Reference Standard | 36282-47-0 | 100MG | $584 | 2026-04-30 | Buy |
| Sigma-Aldrich | 42965 | Tramadol hydrochloride ≥99.0% (HPLC) | 36282-47-0 | 1G | $89.8 | 2023-01-07 | Buy |
| Sigma-Aldrich | 42965 | Tramadol hydrochloride ≥99.0% (HPLC) | 36282-47-0 | 5G | $310 | 2023-01-07 | Buy |
Tramadol hydrochloride Chemical Properties,Uses,Production
Description
cis-Tramadol (Item No. 15919) is an analytical reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
Description
cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is a certified reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Chemical Properties
White Solid
Uses
cis-Tramadol is an analgesic that activates the μ-opioid receptor (IC50 = 7.6 μM). It also inhibits serotonin and norepinephrine reuptake and blocks voltage-gated sodium channels. This product is intended for forensic and research applications.[Cayman Chemical]
Uses
An analgesic.
Definition
ChEBI: (R,R)-tramadol hydrochloride is a hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride; the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist and a serotonin uptake inhibitor. It contains a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol hydrochloride.
References
[1] LIMING SHAO. Derivatives of tramadol for increased duration of effect[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 3: Pages 691-694. DOI: 10.1016/j.bmcl.2005.10.024
