4-broMo-2-(difluoroMethoxy)pyridine
- CAS No.
- 832735-56-5
- Chemical Name:
- 4-broMo-2-(difluoroMethoxy)pyridine
- Synonyms
- 4-broMo-2-(difluoroMethoxy)pyridine;Pyridine,4-bromo-2-(difluoromethoxy)-
- CBNumber:
- CB02553708
- Molecular Formula:
- C6H4BrF2NO
- Molecular Weight:
- 224
- MDL Number:
- MFCD14584703
- MOL File:
- 832735-56-5.mol
- MSDS File:
- SDS
| Boiling point | 198.6±35.0 °C(Predicted) |
|---|---|
| Density | 1.670±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 0+-.0.10(Predicted) |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C6H4BrF2NO/c7-4-1-2-10-5(3-4)11-6(8)9/h1-3,6H |
| InChIKey | QKZHLBZNEBCOLM-UHFFFAOYSA-N |
| SMILES | C1(OC(F)F)=NC=CC(Br)=C1 |
| CAS DataBase Reference | 832735-56-5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933599590 |
4-broMo-2-(difluoroMethoxy)pyridine price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC201316 | 4-Bromo-2-(difluoromethoxy)pyridine >98% | 832735-56-5 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC201316 | 4-Bromo-2-(difluoromethoxy)pyridine >98% | 832735-56-5 | 250mg | $22 | 2026-06-04 | Buy |
| Apolloscientific | PC201316 | 4-Bromo-2-(difluoromethoxy)pyridine >98% | 832735-56-5 | 1g | $51 | 2026-06-04 | Buy |
| Apolloscientific | PC201316 | 4-Bromo-2-(difluoromethoxy)pyridine >98% | 832735-56-5 | 5g | $222 | 2026-06-04 | Buy |
| Apolloscientific | PC201316 | 4-Bromo-2-(difluoromethoxy)pyridine >98% | 832735-56-5 | 25g | $882 | 2026-06-04 | Buy |
4-broMo-2-(difluoroMethoxy)pyridine Chemical Properties, Uses, Production
Synthesis
36953-37-4
1895-39-2
832735-56-5
General procedure for the synthesis of 4-bromo-2-difluoromethoxypyridine from 4-bromo-2-hydroxypyridine and sodium 2-chloro-2,2-difluoroacetate: Example 26i: 4-Bromo-2-hydroxypyridine (200 mg, 1.15 mmol) and sodium 2-chloro-2,2-difluoroacetate (210 mg, 1.38 mmol) were suspended in dry acetonitrile (8 mL). The reaction mixture was heated to reflux overnight and subsequently cooled to room temperature. The reaction mixture was extracted directly with pentane (3 × 5 mL). The organic phases were combined and concentrated to afford 219 mg (85% yield) of 4-bromo-2-difluoromethoxypyridine. Product characterization data were as follows: 1H-NMR (500 MHz, DMSO-d6) δ 8.18 (d, 1H), 7.70 (t, 1H), 7.56 (d, 1H), 7.50 (s, 1H); mass spectra (CI+) m/z 226, 224 [M + 1]+.
References
[1] Patent: US2010/125087, 2010, A1. Location in patent: Page/Page column 21
[2] Patent: WO2018/2760, 2018, A1. Location in patent: Page/Page column 100
4-broMo-2-(difluoroMethoxy)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4-broMo-2-(difluoroMethoxy)pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2445 | 58 |
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| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
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| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Chengdu DingDang Pharmaceutical Co., Ltd. | 028-86040038 | market@dingdangchem.com | China | 1853 | 55 |
