1-(2-fluoro-3-nitrophenyl)ethanone
- CAS No.
- 873697-78-0
- Chemical Name:
- 1-(2-fluoro-3-nitrophenyl)ethanone
- Synonyms
- 1-(2-fluoro-3-nitrophenyl)ethan-1-one;2’-Fluoro-3’-nitroacetophenone;2'-Fluoro-3'-nitroacetophenone 95%;1-(2-fluoro-3-nitrophenyl)ethanone;Ethanone, 1-(2-fluoro-3-nitrophenyl)-
- CBNumber:
- CB02609340
- Molecular Formula:
- C8H6FNO3
- Molecular Weight:
- 183.14
- MDL Number:
- MFCD13194361
- MOL File:
- 873697-78-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| HS Code | 2914790090 |
1-(2-fluoro-3-nitrophenyl)ethanone price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | YJB69778 | 2'-Fluoro-3'-nitroacetophenone | 873697-78-0 | 2.5g | $295 | 2026-06-05 | Buy |
| Apolloscientific | PC501170 | 2'-Fluoro-3'-nitroacetophenone 95% | 873697-78-0 | 1g | $85 | 2026-06-04 | Buy |
| Apolloscientific | PC501170 | 2'-Fluoro-3'-nitroacetophenone 95% | 873697-78-0 | 5g | $258 | 2026-06-04 | Buy |
| Apolloscientific | PC501170 | 2'-Fluoro-3'-nitroacetophenone 95% | 873697-78-0 | 25g | $901 | 2026-06-04 | Buy |
| Matrix Scientific | 292608 | 1-(2-Fluoro-3-nitrophenyl)ethanone | 873697-78-0 | 250.00mg | $80 | 2026-05-19 | Buy |
1-(2-fluoro-3-nitrophenyl)ethanone Chemical Properties, Uses, Production
Synthesis
58534-94-4
97674-02-7
873697-78-0
General procedure for the synthesis of 1-(2-fluoro-3-nitrophenyl)ethanone from 2-fluoro-3-bromonitrobenzene and tributyl(1-ethoxyvinyl)tin: Dichlorobis(triphenylphosphine)palladium(II) (1.6 g, 2.28 mmol, 0.05 eq.) was added to a dioxane solution of 2-fluoro-3-bromonitrobenzene (100 mL, 10.0 g, 45.6 mmol, 1 eq.). 1equivalent), the resulting turbid solution was heated at 90 °C for 4 h. The solution gradually changed to dark brown during the reaction. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent 30% methyl tert-butyl ether/heptane) and after confirming the complete conversion of the feedstock, the reaction mixture was cooled to room temperature. A saturated solution of potassium fluoride (KF, 100 mL) and ethyl acetate (100 mL) was added to the reaction mixture and the two-phase mixture was stirred for 1 h. The mixture was subsequently filtered through diatomaceous earth and washed with ether. The organic layer was separated, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product as a brown oil in the form of an enol ether. The crude product was dissolved in tetrahydrofuran (THF, 50 mL), 2N hydrochloric acid (50 mL) was added and the reaction mixture was stirred at room temperature. After completion of the reaction, the reaction mixture was saturated with sodium chloride (NaCl) and extracted with methyl tert-butyl ether (MTBE, 2 x 150 mL). The organic layers were combined, washed once with brine (30 mL), dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with an eluent of 0-40% ethyl acetate/heptane gradient solution. The fraction containing the target product was collected and the solvent was evaporated under reduced pressure to give 1-(2-fluoro-3-nitrophenyl)ethanone as a yellow oil (7.1 g, 86% yield).
References
[1] Patent: CN105228983, 2016, A. Location in patent: Paragraph 0697; 0698; 0699
[2] Patent: WO2017/89453, 2017, A1. Location in patent: Page/Page column 44; 45
1-(2-fluoro-3-nitrophenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-fluoro-3-nitrophenyl)ethanone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Jalor-Chem co.,LTD | 0510-0510-86396359 13382276200 | sales@jalor-chem.com | China | 1000 | 56 |
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| Shanghai Anmike Chemical Co. Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 9988 | 55 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 9999 | 58 |
| Xinyi Kaiwu Chemical Technology Co., Ltd. | 0516-0516-88997009 18651776937 | 4164357@qq.com | China | 3204 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
