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4'-Fluoro-3'-nitroacetophenone

4'-Fluoro-3'-nitroacetophenone Structure
4'-Fluoro-3'-nitroacetophenone structure
CAS No.
400-93-1
Chemical Name:
4'-Fluoro-3'-nitroacetophenone
Synonyms
4-FLUORO-3-NITROACETOPHENONE;1-(4-Fluoro-3-nitrophenyl)ethan-1-one;4′-Fluor-3′-nitroacetophenon;4-Fluoro-3-nitroacetophneone;4'-Fuoro-3'-nitroacetophenone;4-FLUORO-3'-NITROACETOPHENONE;4'-Fluoro-3'-notroacetophenone;4'-Fluoro-3'-nitroacetophenone;4'-Fluoro-3'-nitroacetophenone>4'-Fluoro-3'-nitroacetophenone,98%
CBNumber:
CB0154158
Molecular Formula:
C8H6FNO3
Molecular Weight:
183.14
MDL Number:
MFCD00115369
MOL File:
400-93-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 17:20:15
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4'-Fluoro-3'-nitroacetophenone Properties

Melting point 47-51 °C
Boiling point 118-120°C 0,8mm
Density 1.336±0.06 g/cm3(Predicted)
Flash point 118-120°C/0.8mm
storage temp. Sealed in dry,Room Temperature
solubility soluble in Methanol
form Crystalline Powder
color Light yellow
BRN 2211976
InChI 1S/C8H6FNO3/c1-5(11)6-2-3-7(9)8(4-6)10(12)13/h2-4H,1H3
InChIKey PTCNZDJJIOLIKQ-UHFFFAOYSA-N
SMILES CC(=O)c1ccc(F)c(c1)[N+]([O-])=O
CAS DataBase Reference 400-93-1(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26
WGK Germany  3
HazardClass  IRRITANT
HS Code  29143990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4'-Fluoro-3'-nitroacetophenone price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 676357 4′-Fluoro-3′-nitroacetophenone 97% 400-93-1 1g $44.8 2023-01-07 Buy
Sigma-Aldrich 676357 4′-Fluoro-3′-nitroacetophenone 97% 400-93-1 5g $204 2023-01-07 Buy
TCI Chemical F0777 4'-Fluoro-3'-nitroacetophenone >98.0%(GC) 400-93-1 5g $77 2026-04-30 Buy
TCI Chemical F0777 4'-Fluoro-3'-nitroacetophenone >98.0%(GC) 400-93-1 25g $302 2026-04-30 Buy
Biosynth FF53823 4'-Fluoro-3'-nitroacetophneone 400-93-1 50g $150 2026-06-04 Buy
Product number Packaging Price Buy
676357 1g $44.8 Buy
676357 5g $204 Buy
F0777 5g $77 Buy
F0777 25g $302 Buy
FF53823 50g $150 Buy

4'-Fluoro-3'-nitroacetophenone Chemical Properties, Uses, Production

Chemical Properties

light yellow crystalline powder

Uses

4''-Fluoro-3''-nitroacetophenone is used as reactant/reagent in preparation of substituted furans via copper-catalyzed radical addition of acetophenones to alkynes.

Synthesis

4-Fluoroacetophenone

403-42-9

4'-Fluoro-3'-nitroacetophenone

400-93-1

General procedure for the synthesis of 4-fluoro-3-nitroacetophenone from 4-fluoroacetophenone: 1-(4-fluorophenyl)ethanone (1.10 g, 7.97 mmol) was dissolved in concentrated H2SO4 (5 mL) under stirring conditions. Subsequently, a mixed acid consisting of concentrated HCl and concentrated H2SO4 (2 mL) was slowly added. HNO3 (1.50 mL) was added slowly and dropwise at -15°C. The reaction mixture was continued to be stirred at -15 °C for 80 min, after which it was poured into ice-cold H2O (120 mL) and extracted with EtOAc (2 × 100 mL). The organic layers were combined and washed sequentially with H2O (100 mL) and brine (100 mL), and the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel, 100-200 mesh, 40% EtOAc in hexane solution) to afford 4-fluoro-3-nitroacetophenone (0.80 g, 55%) as an off-white solid.1H NMR (400 MHz, CDCl3) δ 2.64 (s, 3H), 7.39 (t, J=9.30 Hz, 1H), 8.20- 8.26 (m, 1H), 8.57-8.66 (m, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 10, p. 1725 - 1728
[2] Patent: WO2017/89453, 2017, A1. Location in patent: Page/Page column 55
[3] Patent: WO2007/103260, 2007, A1. Location in patent: Page/Page column 63-64
[4] Archiv der Pharmazie (Weinheim, Germany), 1957, vol. 290, p. 587,595
[5] Archiv der Pharmazie, 1963, vol. 296, p. 324 - 336

4'-Fluoro-3'-nitroacetophenone Preparation Products And Raw materials

Raw materials

4-Fluoroacetophenone

Preparation Products

Ethanone, 1-[4-(4-methylphenoxy)-3-nitrophenyl]- 1-(4-Fluoro-3-nitro-phenyl)-ethanol 1-(4-Morpholino-3-nitrophenyl)-1-ethanone 1-(3-Nitro-4-piperidinophenyl)-1-ethanone

4'-Fluoro-3'-nitroacetophenone Suppliers

Global Suppliers ( 251)
Supplier Tel Email Country ProdList Advantage
Wuhan EnTai Technology Development Co,.Ltd 86-27-82330560 2536851935@qq.com China 346 69
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Supplier Advantage
Wuhan EnTai Technology Development Co,.Ltd 69
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
INTATRADE GmbH 66
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Ark Pharm, Inc. 56

View Latest Price from 4'-Fluoro-3'-nitroacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-Fluoro-3'-nitroacetophenone pictures 2026-08-07 4'-Fluoro-3'-nitroacetophenone
400-93-1
 $1.00-12.00 1KG 99% 1000KG Shaanxi Dideu Medichem Co. Ltd
4'-Fluoro-3'-nitroacetophenone pictures 2026-03-20 4'-Fluoro-3'-nitroacetophenone
400-93-1
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
4'-Fluoro-3'-nitroacetophenone pictures 2022-02-21 4'-Fluoro-3'-nitroacetophenone
400-93-1
 1KG 98.1% 100 tons Honest Joy Holdings Limited

4'-Fluoro-3'-nitroacetophenone Spectrum

4'-Fluoro-3'-nitroacetophenone(400-93-1)1HNMR4'-Fluoro-3'-nitroacetophenone(400-93-1)FT-IR

400-93-1 (4'-Fluoro-3'-nitroacetophenone) Related Search:

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4'-Fluoro-3'-nitroacetophenone,98% 1-(4-Fluoro-3-nitrophenyl)ethan-1-one, 5-Acetyl-2-fluoronitrobenzene 4-Fluoro-3-nitroacetophneone 4′-Fluor-3′-nitroacetophenon 4'-Fluoro-3'-notroacetophenone Ethanone, 1-(4-fluoro-3-nitrophenyl)- 4-FLUORO-3'-NITROACETOPHENONE 1-(4-FLUORO-3-NITRO-PHENYL)-ETHANONE 4'-fluoro-3'-nitroacetophenone,1-(3-nitro-4-fluorophenyl)ethanone 4'-Fuoro-3'-nitroacetophenone JR-6819, 1-(4-Fluoro-3-nitrophenyl)ethanone, 97% 4'-Fluoro-3'-nitroacetophenone> 4'-Fluoro-3'-nitroacetophenone 4′-Fluoro-3′-nitroacetophenone, CAS 400-93-1 1-(4-Fluoro-3-nitrophenyl)ethan-1-one 4-FLUORO-3-NITROACETOPHENONE 400-93-1 C8H6FNO3 Ketones Organic Building Blocks C7 to C8 Carbonyl Compounds Building Blocks C7 to C8 Miscellaneous ketone Carbonyl Compounds Ketones Acetophenone series