MK-5046
- CAS No.
- 1022152-70-0
- Chemical Name:
- MK-5046
- Synonyms
- CS-2034;MK-5046;MK5046 peak 2;(2S)-1,1,1-TRIFLUORO-2-(4-PYRAZOL-1-YLPHENYL)-3-[5-[[1-(TRIFLUOROMETHYL)CYCLOPROPYL]METHYL]-1H-IMIDAZOL-2-YL]PROPAN-2-OL;1H-Imidazole-2-ethanol, α-[4-(1H-pyrazol-1-yl)phenyl]-α-(trifluoromethyl)-5-[[1-(trifluoromethyl)cyclopropyl]methyl]-, (αS)-;(2S)-1,1,1-Trifluoro-2-[4-(1H-pyrazol-1-yl)phenyl]-3-(4-{[1-(trif luoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)-2-propanol;(alphaS)-alpha-[4-(1H-Pyrazol-1-yl)phenyl]-alpha-(trifluoromethyl)-5-[[1-(trifluoromethyl)cyclopropyl]methyl]-1H-imidazole-2-ethanol
- CBNumber:
- CB02628147
- Molecular Formula:
- C20H18F6N4O
- Molecular Weight:
- 444.38
- MDL Number:
- MFCD18782708
- MOL File:
- 1022152-70-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| MK-5046 99.75% | CS-4808 | 1mg | $108 |
| MK-5046 99.75% | CS-4808 | 5mg | $238 |
| MK-5046 99.75% | CS-4808 | 10mg | $379 |
| MK-5046 99.75% | CS-4808 | 25mg | $747 |
| MK-5046 99.75% | CS-4808 | 50mg | $1192 |
| Boiling point | 571.6±50.0 °C(Predicted) |
|---|---|
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 11.22±0.15(Predicted) |
| color | White to light yellow |
| FDA UNII | QHZ72H8F6P |
MK-5046 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-4808 | MK-5046 99.75% | 1022152-70-0 | 1mg | $108 | 2026-06-04 | Buy |
| ChemScene | CS-4808 | MK-5046 99.75% | 1022152-70-0 | 5mg | $238 | 2026-06-04 | Buy |
| ChemScene | CS-4808 | MK-5046 99.75% | 1022152-70-0 | 10mg | $379 | 2026-06-04 | Buy |
| ChemScene | CS-4808 | MK-5046 99.75% | 1022152-70-0 | 25mg | $747 | 2026-06-04 | Buy |
| ChemScene | CS-4808 | MK-5046 99.75% | 1022152-70-0 | 50mg | $1192 | 2026-06-04 | Buy |
MK-5046 Chemical Properties,Uses,Production
Uses
MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity[1][2][3].
in vivo
MK-5046 (3, 10 and 30 mg/kg; oral administration for once) inhibits food intake, and increases resting metabolic rate (MR) and body temperature in DIO mice[1]. MK-5046 (5, 25 and 50 mg/kg; s.c. once daily for 14 days) significantly reduces body weight and food intake in DIO mice[1].
| Animal Model: | Male C57BL/6N mice with high-fat diet for the diet-induced obese (DIO) model[1] |
| Dosage: | 3, 10 and 30 mg/kg |
| Administration: | Oral administration; 3, 10 and 30 mg/kg for once |
| Result: | Dose-dependently inhibited food intake at 2 h and overnight in DIO mice. But showed no effect on Brs3 knockout mice. |
References
[1] Guan XM, et al. Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist. J Pharmacol Exp Ther. 2011 Feb;336(2):356-364. DOI:10.1124/jpet.110.174763
[2] Sebhat IK, et al. Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2010 Oct 18;2(1):43-47. DOI:10.1021/ml100196d
[3] Ramos-Alvarez I, et al. The Nonpeptide Agonist MK-5046 Functions As an Allosteric Agonist for the Bombesin Receptor Subtype-3. J Pharmacol Exp Ther. 2022 Aug;382(2):66-78. DOI:10.1124/jpet.121.001033
MK-5046 Preparation Products And Raw materials
MK-5046 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| ChemCell Biomedicine Co.,Ltd. | 020-13556033878 2965585218 13556033878 | chemcell@hotmail.com | China | 369 | 52 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3853 | 58 |
