PF-03758309 (hydrochloride)
- CAS No.
- 1279034-84-2
- Chemical Name:
- PF-03758309 (hydrochloride)
- Synonyms
- PF-3758309 hydrochloride;PF-03758309 (hydrochloride);PF-03758309 Dihydrochloride;PF-3758309 hydrochloride, 10 mM in DMSO;growth,PF3758309 hydrochloride,p21 activated kinases,proliferation,survival,signaling,PF 03758309,ATP-competitive,PF 3758309 hydrochloride,oncogenic,PF3758309,PF-03758309,PF03758309,PF 3758309,inhibit,tumor,PF-3758309,PAK,Apoptosis,Inhibitor
- CBNumber:
- CB02667470
- Molecular Formula:
- C25H31ClN8OS
- Molecular Weight:
- 527.09
- MDL Number:
- MOL File:
- 1279034-84-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| FDA UNII | BS52H27235 |
|---|
PF-03758309 (hydrochloride) price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA009WMF | 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8h)-one hydrochloride | 1279034-84-2 | 1mg | $50 | 2026-05-28 | Buy |
| aablocks | AA009WMF | 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8h)-one hydrochloride | 1279034-84-2 | 2mg | $60 | 2026-05-28 | Buy |
| aablocks | AA009WMF | 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8h)-one hydrochloride | 1279034-84-2 | 5mg | $80 | 2026-05-28 | Buy |
| aablocks | AA009WMF | 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8h)-one hydrochloride | 1279034-84-2 | 10mg | $116 | 2026-05-28 | Buy |
| aablocks | AA009WMF | 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8h)-one hydrochloride | 1279034-84-2 | 25mg | $173 | 2026-05-28 | Buy |
PF-03758309 (hydrochloride) Chemical Properties, Uses, Production
Uses
PF-3758309 (PF-03758309) hydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM). PF-3758309 hydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation[1][2][3].
in vivo
PF-3758309 hydrochloride (7.5-30 mg/kg; p.o.; twice daily for 9-18 days) results in statistically significant tumor growth inhibition (TGI) in HCT116 and A549 models[1].
| Animal Model: | Female nu/nu, CRL breed 6–8 weeks old mice (bearing HCT116 and A549 tumors)[1] |
| Dosage: | 7.5-30 mg/kg |
| Administration: | Oral administration; twice daily for 9-18 days |
| Result: | Significant tumor growth inhibition (TGI) in HCT116 and A549 models. |
IC 50
PAK4: 18.7 nM (Ki); PAK1: 13.7 nM (Ki); PAK5: 18.1 nM (Ki); PAK6: 17.1 nM (Ki); PAK2: 190 nM (IC50); PAK3: 99 nM (IC50); PAK4: 2.7 nM (Kd)
References
[1] Murray, Brion W., et al. Small-molecule p21-activated kinase inhibitor PF3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proceedings of the National Academy of Sciences of the United States of America (2010), 107(20), 9446-9451, S94. DOI:10.1073/pnas.0911863107
[2] Zhao ZS, et al. Do PAKs make good drug targets F1000 Biol Rep. 2010 Sep 23;2:70. DOI:10.3410/B2-70
[3] Ryu BJ, et al. PF-3758309, p21-activated kinase 4 inhibitor, suppresses migration and invasion of A549 human lung cancer cells via regulation of CREB, NF-κB, and β-catenin signalings. Mol Cell Biochem. 2014 Apr;389(1-2):69-77. DOI:10.1007/s11010-013-1928-8
PF-03758309 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
PF-03758309 (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4183 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9869 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
View Latest Price from PF-03758309 (hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | PF-3758309 hydrochloride
1279034-84-2
|
$74.00-191.00 | 98.83% | 10g | TargetMol Chemicals Inc. |
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- PF-3758309 hydrochloride
1279034-84-2
- $74.00-191.00
- 98.83%
- TargetMol Chemicals Inc.
