ChemicalBook >> CAS DataBase List >>NSC 55712
NSC 55712
- CAS No.
- 2076-91-7
- Chemical Name:
- NSC 55712
- Synonyms
- R 55;NSC 55712;TPT-260 2HCl;TPT-260 , NSC55712;TPT-260 2HCl (R55);TPT-260 2HCl(NSC55712);TPT-260 (hydrochloride);TPU-260 Dihydrochloride;NSC55712 Dihydrochloride;TPT-260 (Dihydrochloride)
- CBNumber:
- CB02667773
- Molecular Formula:
- C8H14Cl2N4S3
- Molecular Weight:
- 333.32456
- MDL Number:
- MFCD25976641
- MOL File:
- 2076-91-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-07-16 07:06:08
| Melting point | 210℃ (Decomposition) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO:62.5(Max Conc. mg/mL);240.02(Max Conc. mM) |
| form | A crystalline solid |
| color | Light yellow to yellow |
| Water Solubility | water: 50mg/mL |
| InChIKey | DSODRWWHAUGSGD-UHFFFAOYSA-N |
| SMILES | [s]1c(ccc1CSC(=[N+H2])N)CSC(=[N+H2])N.[Cl-].[Cl-] |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
NSC 55712 price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16079 | TPT-260 (hydrochloride) ≥95% | 2076-91-7 | 1mg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 16079 | TPT-260 (hydrochloride) ≥95% | 2076-91-7 | 5mg | $154 | 2026-04-30 | Buy |
| Cayman Chemical | 16079 | TPT-260 (hydrochloride) ≥95% | 2076-91-7 | 10mg | $259 | 2026-04-30 | Buy |
| Cayman Chemical | 16079 | TPT-260 (hydrochloride) ≥95% | 2076-91-7 | 25mg | $527 | 2026-04-30 | Buy |
| ChemScene | CS-2805 | TPT-260 Dihydrochloride 98.0% | 2076-91-7 | 5mg | $129 | 2026-06-04 | Buy |
NSC 55712 Chemical Properties, Uses, Production
Uses
Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 μM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.[Cayman Chemical]
Biological Activity
Cell permeable: yes', 'Primary Target
vacuolar protein sorting (Vps) proteins', 'Reversible: yes
NSC 55712 Preparation Products And Raw materials
Raw materials
Preparation Products
Global Suppliers ( 72)
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| D&C Chemicals | +86-21-58447131 | 1724405207@qq.com | China | 470 | 55 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3853 | 58 |
View Latest Price from NSC 55712 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | TPT-260 Dihydrochloride
2076-91-7
|
$55.00-176.00 | 99.98% | 10g | TargetMol Chemicals Inc. |
-
- TPT-260 Dihydrochloride
2076-91-7
- $55.00-176.00
- 99.98%
- TargetMol Chemicals Inc.
2076-91-7 (NSC 55712) Related Search:
NSC 55712
TPT-260 (Dihydrochloride)
THIOPHENE-2,5-DIYLBIS(METHYLENE) DICARBAMIMIDOTHIOATE.2HCL
TPT-260 (Dihydrochloride), NSC55712
TPT-260 2HCl
Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride
Carbamimidothioic acid,C,C'-[2,5-thiophenediylbis(methylene)] ester, hydrochloride (1:2)
TPT-260 , NSC55712
NSC 55712 Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride
TPT-260 Dihydrochloride, >=98%
Thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride
NSC55712 Dihydrochloride
TPT-260 2HCl(NSC55712)
R 55
TPT-260 (hydrochloride)
thiene-2,5-diyldimethanediyl dicarbamimidothioate
NSC55712; TPT260 DIHYDROCHLORIDE; TPT 260 DIHYDROCHLORIDE; TPU-260 DIHYDROCHLORIDE;NSC-55712;NSC 55712
TPU-260 Dihydrochloride
[({5-[(carbamimidoylsulfanyl)methyl]thiophen-2-yl}methyl)sulfanyl]methanimidamide dihydrochloride
TPT-260 2HCl (R55)
TPT 260 Dihydrochloride,Inhibitor,inhibit,TPU 260,TPU260,TPT260 Dihydrochloride,NSC 55712,TPU-260,NSC-55712
Carbamimidothioic acid, C,C'-[2,5-thiophenediylbis(methylene)] ester, hydrochloride (1:2)
TPT-260 Dihydrochloride, 10 mM in DMSO
2076-91-7
C8H12N4S32HCl
C8H14Cl2N4S3
C8H12N4S32ClH
Inhibitors
