PI-3065
- CAS No.
- 955977-50-1
- Chemical Name:
- PI-3065
- Synonyms
- 129556;PI-306;PI-3065;CS-1274;PI-3065, >=98%;PI-3065|PI3065;PI-3065 USP/EP/BP;PI-3065, 10 mM in DMSO;4-(6-((4-(Cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)thieno[3,2-d]pyri;6-((4-(cyclopropylmethyl)piperazin-1-yl)methyl)-2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidine
- CBNumber:
- CB02705093
- Molecular Formula:
- C27H31FN6OS
- Molecular Weight:
- 506.64
- MDL Number:
- MFCD28167771
- MOL File:
- 955977-50-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| PI-3065 ≥98% | 9002394 | 1mg | $40 |
| PI-3065 ≥98% | 9002394 | 5mg | $171 |
| PI-3065 ≥98% | 9002394 | 10mg | $302 |
| PI-3065 ≥98% | 9002394 | 25mg | $609 |
| PI-3065 98.97% | CS-3100 | 5mg | $97 |
| More product size | |||
| Density | 1.372±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | ≥22.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 14.80±0.30(Predicted) |
| color | White to off-white |
| InChIKey | YDNOHCOYQVZOMC-UHFFFAOYSA-N |
| SMILES | C1(C2=C(F)C=CC3=C2C=CN3)=NC(N2CCOCC2)=C2SC(CN3CCN(CC4CC4)CC3)=CC2=N1 |
| CAS DataBase Reference | 955977-50-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H332 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501 | |||||||||
| NFPA 704 |
|
PI-3065 price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9002394 | PI-3065 ≥98% | 955977-50-1 | 1mg | $40 | 2026-04-30 | Buy |
| Cayman Chemical | 9002394 | PI-3065 ≥98% | 955977-50-1 | 5mg | $171 | 2026-04-30 | Buy |
| Cayman Chemical | 9002394 | PI-3065 ≥98% | 955977-50-1 | 10mg | $302 | 2026-04-30 | Buy |
| Cayman Chemical | 9002394 | PI-3065 ≥98% | 955977-50-1 | 25mg | $609 | 2026-04-30 | Buy |
| ChemScene | CS-3100 | PI-3065 98.97% | 955977-50-1 | 5mg | $97 | 2026-06-04 | Buy |
PI-3065 Chemical Properties,Uses,Production
Biological Activity
pi-3065 is a small molecule and selective inhibitor of p110δkinase with an ki value of 1.5nm and ic50 value of 5nm [1].pi-3065 has been reported to selectively inhibit p110δkinase with ki values of 15nm, 110nm, 130nm and 940nm, ic50 values of 5nm, 91nm, 600nm and >10000nm for p110δ, p110α, p110β and p110γ, respectively. in addition, pi-3065 has been revealed to inhibit 4t1 tumour growth and metastasis. pi-3065 has also noted to prolong survival and reduce the incidence of macroscopic metastases and other disease-associated pathologies [1].
in vitro
PI-3065 shows no inhibition on the growth of 4T1 cells, which do not expressing detectable levels of p110δ.
target
| p110α 910 nM (IC 50 ) | p110β 600 nM (IC 50 ) | p110δ 5 nM (IC 50 ) |
storage
Store at -20°C
PI-3065 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29091 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +86-15988602810 | sales@anbuchem.com | China | 5812 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9930 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1158 | 58 |
