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PFI-2 (hydrochloride)

PFI-2 (hydrochloride) Structure
PFI-2 (hydrochloride) structure
CAS No.
1627607-87-7
Chemical Name:
PFI-2 (hydrochloride)
Synonyms
(R)-PFI-2;PFI-2 HCl salt;PFI-2 HCl ，S7294;PFI-2 (hydrochloride);(R)-PFI-2 (hydrochloride);PFI-2; PFI2;PFI 2;R PFI-2;R-PFI2;PFI-2 hydrochloride, 10 mM in DMSO;(1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride;(R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride;macrophage,chronic kidney disease,inhibit,Histone Methyltransferase,PFI-2,Inhibitor,SET domain containing lysine methyltransferase 7 (SETD7),PFI2 hydrochloride,renal fibrosis,inflammation,PFI 2,PFI2,PFI 2 hydrochloride
CBNumber:
CB83041444
Molecular Formula:
C23H26ClF4N3O3S
Molecular Weight:
535.98
MDL Number:
MFCD28133380
MOL File:
1627607-87-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08
Product description Number Pack Size Price
(R)-PFI-2 ≥97% (HPLC) SML1408 5mg $217
(R)-PFI-2 ≥97% (HPLC) SML1408 25mg $848
(R)-PFI-2 (hydrochloride) ≥95% 14678 1mg $28
(R)-PFI-2 (hydrochloride) ≥95% 14678 5mg $83
(R)-PFI-2 (hydrochloride) ≥95% 14678 10mg $152
More product size
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PFI-2 (hydrochloride) Properties

Melting point >209°C (dec.)
storage temp. 2-8°C
solubility Soluble in DMSO (up to at least 25 mg/ml)
form powder
color white to beige
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey ZADKZNVAJGEFLC-GKNLIIIVNA-N
SMILES FC1C=C(S(=O)(=O)N[C@@H](C(N2CCCC2)=O)CC2C=CC=C(C(F)(F)F)C=2)C=C2CCNCC=12.Cl |&1:8,r|
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral

PFI-2 (hydrochloride) price More Price(58)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1408 (R)-PFI-2 ≥97% (HPLC) 1627607-87-7 5mg $217 2026-04-30 Buy
Sigma-Aldrich SML1408 (R)-PFI-2 ≥97% (HPLC) 1627607-87-7 25mg $848 2026-04-30 Buy
Cayman Chemical 14678 (R)-PFI-2 (hydrochloride) ≥95% 1627607-87-7 1mg $28 2026-04-30 Buy
Cayman Chemical 14678 (R)-PFI-2 (hydrochloride) ≥95% 1627607-87-7 5mg $83 2026-04-30 Buy
Cayman Chemical 14678 (R)-PFI-2 (hydrochloride) ≥95% 1627607-87-7 10mg $152 2026-04-30 Buy
Product number Packaging Price Buy
SML1408 5mg $217 Buy
SML1408 25mg $848 Buy
14678 1mg $28 Buy
14678 5mg $83 Buy
14678 10mg $152 Buy

PFI-2 (hydrochloride) Chemical Properties,Uses,Production

Description

SET domain-containing protein 7/9 (SET7/9) is a histone methyltransferase that monomethylates lysine 4 of histone H3, which generates a specific tag for epigenetic transcriptional activation. It plays a role in the transcriptional activation of tumor suppressor p53 in response to DNA damage as well as the transcription factor TAF10. (R)-PFI-2 is a potent, cell-permeable inhibitor of SET7/9 (IC50 = 2 nM) that demonstrates greater than 1,000-fold selectivity over a panel of 18 other methyltransferases. Its enantiomer, (S)-PFI-2 , is 500-fold less active (IC50 = 1 μM). See the Structural Genomics Consortium (SGC) website for more information.

Uses

(1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide Hydrochloride known as (-)-PFI-2 HCl is a cell permeable inhibitor of SET Domain-Containing protein 7/9 (SET 7/9) which plays a role in tumorigenesis in cell cancer lines.

Biochem/physiol Actions

(R)-PFI-2 is a histone-lysine N-methyltransferase (HKMT) inhibitor selective for SETD7 (also known as SET9). (R)-PFI-2 has an IC50 value of 2 nM and 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. For full characterization details, please visit the PFI-2 probe summary on the Structural Genomics Consortium (SGC) website.(S)-PFI-2, an enantiomer of (R)-PFI-2, is used as a negative control. (S)-PFI-2 is available from Sigma. To learn more about and purchase (S)-PFI-2, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

in vivo

PFI-2 hydrochloride (i.p., 200 μM, twice a week) attenuates the progression of renal fibrosis and preserves renal function in FA nephropathy[2].
PFI-2 hydrochloride (i.p., 200 μM, twice a week) reduced ECM accumulation and fibroblasts activation after FA injury[2].
PFI-2 hydrochloride (i.p., 200 μM, twice a week) impeded Th2 cytokine signaling activation and M2 macrophage polarization[2].
PFI-2 hydrochloride (i.p., 200 μM, twice a week) suppressed M2 macrophages-myofibroblasts transition and myeloid myofibroblasts accumulation in the FA-treated kidneys[2].
PFI-2 hydrochloride (i.p., 200 μM, twice a week) attenuated macrophages M2 polarization and M2 macrophages-to-myofibroblasts transition in obstructed kidneys[2].
PFI-2 hydrochloride (i.p., 200 μM, twice a week) suppressed myeloid myofibroblast accumulation and renal fibrosis after UUO injury[2].
PFI-2 hydrochloride (i.p., 200 μM, twice a week) reduced the infiltration of inflammatory cells, the production of inflammatory molecules, and NF-κB activation in FA nephropathy[2].

Animal Model:Male C57BL/6 mice (8-10-week old, 20-25 g)[2]
Dosage:200 μM (PFI-2 is diluted in 100 μL 0.1% (v/v) DMSO to a concentration of 200 μM/100 μL)
Administration:intraperitoneal injection, twice a week
Result:Presented less bone marrow-derived myofibroblasts, fewer CD206+/α-smooth muscle actin + cells and developed less renal fibrosis (P<0.01).
Reduced the infiltration of inflammatory cells and decreased the production of pro-inflammatory cytokines and chemokines in the kidneys after folic acid treatment (P<0.01).
Suppressed the accumulation of NF-κB p65+ cells in folic acid nephropathy (P<0.01).

IC 50

SETD7/KMT7

storage

Store at -20°C

References

[1] DALIA BARSYTE-LOVEJOY. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 35: 12853-12858. DOI:10.1073/pnas.1407358111

PFI-2 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

PFI-2 (hydrochloride) Suppliers

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Baoji Guokang Healthchem Co., Ltd. 		+86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9035 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +8619957148339 market18@leapchem.com China 24569 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38999 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Aladdin Scientific 		tp@aladdinsci.com United States 54746 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131885 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-13601744364 13601744364 chemsharker@126.com China 1158 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
Baoji Guokang Healthchem Co., Ltd. 		58
BOC Sciences 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
TargetMol Chemicals Inc. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Dongyang Biotechnology Co., Ltd. 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55

View Lastest Price from PFI-2 (hydrochloride) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PFI-2 hydrochloride pictures 2026-07-15 PFI-2 hydrochloride
1627607-87-7
 $34.00-77.00 99.89% 10g TargetMol Chemicals Inc.
PFI-2 hydrochloride pictures 2021-07-13 PFI-2 hydrochloride
1627607-87-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
PFI-2 hydrochloride pictures 2021-07-09 PFI-2 hydrochloride
1627607-87-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

PFI-2 (hydrochloride) Spectrum

PFI-2 (hydrochloride)(1627607-87-7)1HNMR

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PFI-2 (hydrochloride) PFI-2 HCl salt (R)-PFI-2 (hydrochloride) (R)-PFI-2 PFI-2; PFI2;PFI 2;R PFI-2;R-PFI2 (1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride (R)-8-Fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride macrophage,chronic kidney disease,inhibit,Histone Methyltransferase,PFI-2,Inhibitor,SET domain containing lysine methyltransferase 7 (SETD7),PFI2 hydrochloride,renal fibrosis,inflammation,PFI 2,PFI2,PFI 2 hydrochloride PFI-2 hydrochloride, 10 mM in DMSO PFI-2 HCl ，S7294 1627607-87-7 C23H25F4N3O3SHCl C23H26ClF4N3O3S API