8α-Tigloyloxyhirsutinolide 13-O-acetate
- CAS No.
- 83182-58-5
- Chemical Name:
- 8α-Tigloyloxyhirsutinolide 13-O-acetate
- Synonyms
- 8α-Tigloyloxyhirsutinolide13-O-acetate;8α-Tigloyloxyhirsutinolide 13-O-acetate;8alpha-Tigloyloxyhirsutinolide 13-O-acetate;[(1R,2E,8S,10R,11S)-6-(Acetyloxymethyl)-11-hydroxy-1,10-dimethyl-5-oxo-4,14-dioxatricyclo[9.2.1.03,7]tetradeca-2,6-dien-8-yl] (E)-2- methylbut-2-enoate;2-Butenoic acid, 2-methyl-, (4S,6R,7S,10R,11E)-3-[(acetyloxy)methyl]-2,4,5,6,7,8,9,10-octahydro-7-hydroxy-6,10-dimethyl-2-oxo-7,10-epoxycyclodeca[b]furan-4-yl ester, (2E)-
- CBNumber:
- CB02725367
- Molecular Formula:
- C22H28O8
- Molecular Weight:
- 420.45
- MDL Number:
- MOL File:
- 83182-58-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 8α-Tigloyloxyhirsutinolide 13-O-acetate | IDA18258 | 1mg | $324.5 |
| 8α-Tigloyloxyhirsutinolide 13-O-acetate | IDA18258 | 5mg | $973.5 |
| 8α-Tigloyloxyhirsutinolide 13-O-acetate | IDA18258 | 10mg | $1298 |
| 8α-Tigloyloxyhirsutinolide 13-O-acetate | IDA18258 | 25mg | $2360 |
| 8α-Tigloyloxyhirsutinolide 13-O-acetate | IDA18258 | 50mg | $4130 |
8α-Tigloyloxyhirsutinolide 13-O-acetate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | IDA18258 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | 83182-58-5 | 1mg | $324.5 | 2026-06-04 | Buy |
| Biosynth | IDA18258 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | 83182-58-5 | 5mg | $973.5 | 2026-06-04 | Buy |
| Biosynth | IDA18258 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | 83182-58-5 | 10mg | $1298 | 2026-06-04 | Buy |
| Biosynth | IDA18258 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | 83182-58-5 | 25mg | $2360 | 2026-06-04 | Buy |
| Biosynth | IDA18258 | 8α-Tigloyloxyhirsutinolide 13-O-acetate | 83182-58-5 | 50mg | $4130 | 2026-06-04 | Buy |
8α-Tigloyloxyhirsutinolide 13-O-acetate Chemical Properties,Uses,Production
Uses
8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo[1][2].
in vivo
8α-Tigloyloxyhirsutinolide 13-O-acetate (5mg/kg, Oral gavage, 5 times per week for 75 days) suppresses tumor growth in mice[1].
| Animal Model: | Five-week-old female athymic nude mice (injected subcutaneously in the right flank area with MDA-MB-468 cells in 100μL PBS) |
| Dosage: | 5mg/kg |
| Administration: | Oral gavage, every day, 5 times per week for 75 days |
| Result: | Inhibited MDA-MB-468 xenografts growth in mice, with reduced pY705-STAT3, G6PD, TrxR1, and GSH levels. |
IC 50
STAT3; Bcl-2; Bcl-xL; Mcl-1
References
[1] Zhu Y, et al. Natural product preferentially targets redox and metabolic adaptations and aberrantly active STAT3 to inhibit breast tumor growth in vivo. Cell Death Dis. 2022 Dec 6;13(12):1022. DOI:10.1038/s41419-022-05477-2
[2] A Bardón, et al. Glaucolides and related sesquiterpene lactones fromVernonia nudiflora and Chrysolaena propinqua. Phytochemistry, 1992, 31(2):609-613.
8α-Tigloyloxyhirsutinolide 13-O-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
8α-Tigloyloxyhirsutinolide 13-O-acetate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 13211707573; | y.liu@mail.biobiopha.com | China | 5645 | 65 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15178 | 58 |
| ALB Technology Limited | 702-983-3769 | sales@albtechnology.com | United States | 2993 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
| Shanghai Binsui Biotechnology Co., Ltd. | 18301908279 18301908279; | 1292752157@qq.com | China | 7684 | 58 |
| Shanghai Bohu Biotechnology Co., LTD | 021-57763112 13585886131 | 3004987436@qq.com | China | 9692 | 58 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14081 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | China | 2017 | 58 |
