BRD4770
- CAS No.
- 1374601-40-7
- Chemical Name:
- BRD4770
- Synonyms
- CS-1814;BRD4770;BRD4770 USP/EP/BP;BRD-4770; BRD 4770;BRD4770, 10 mM in DMSO;Methyl 2-benzamido-1-(3-phenylpropyl)benzimidazole-5-carboxylate;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate;Methyl-2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate;2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate BRD4770
- CBNumber:
- CB02728540
- Molecular Formula:
- C25H23N3O3
- Molecular Weight:
- 413.47
- MDL Number:
- MFCD23143627
- MOL File:
- 1374601-40-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| BRD4770 ≥98% (HPLC) | SML0567 | 5mg | $142 |
| BRD4770 ≥98% (HPLC) | SML0567 | 25mg | $546 |
| BRD4770 ≥98% | 11787 | 1mg | $36 |
| BRD4770 ≥98% | 11787 | 5mg | $103 |
| BRD4770 ≥98% | 11787 | 10mg | $186 |
| More product size | |||
| Density | 1.21±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | 12.12±0.43(Predicted) |
| form | powder |
| color | white to beige |
| InChI | 1S/C25H23N3O3/c1-31-24(30)20-14-15-22-21(17-20)26-25(27-23(29)19-12-6-3-7-13-19)28(22)16-8-11-18-9-4-2-5-10-18/h2-7,9-10,12-15,17H,8,11,16H2,1H3,(H,26,27,29) |
| InChIKey | UCGWYCMPZXDHNR-UHFFFAOYSA-N |
| SMILES | C1(NC(=O)C2=CC=CC=C2)N(CCCC2=CC=CC=C2)C2=CC=C(C(OC)=O)C=C2N=1 |
| CAS DataBase Reference | 1374601-40-7 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
BRD4770 price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0567 | BRD4770 ≥98% (HPLC) | 1374601-40-7 | 5mg | $142 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0567 | BRD4770 ≥98% (HPLC) | 1374601-40-7 | 25mg | $546 | 2026-04-30 | Buy |
| Cayman Chemical | 11787 | BRD4770 ≥98% | 1374601-40-7 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 11787 | BRD4770 ≥98% | 1374601-40-7 | 5mg | $103 | 2026-04-30 | Buy |
| Cayman Chemical | 11787 | BRD4770 ≥98% | 1374601-40-7 | 10mg | $186 | 2026-04-30 | Buy |
BRD4770 Chemical Properties,Uses,Production
Uses
BRD4770 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, decreasing di- and trimethylation on lysine 9 of histone 3 (EC50 = 5 μM). Through its effects on EHMT2, BRD4770 induces senescence in the pancreatic cancer cell line PANC-1 without initiating apoptosis. It also blocks both anchorage-dependent and –independent proliferation of PANC-1 cells.[Cayman Chemical]
Definition
ChEBI: 2-benzamido-1-(3-phenylpropyl)-5-benzimidazolecarboxylic acid methyl ester is a member of benzimidazoles.
Biochem/physiol Actions
BRD4770 is a selective inhibitor of the histone methyltransferase G9a. BRD4770 blocks lysine residue 9 methylation of histone H3 without inducing apoptosis. In PANC-1 cells, BRD4770 activates the ataxia telangiectasia mutated (ATM) pathway, induces senescence and inhibits anchorage-dependent and -independent growth.
IC 50
EHMT2/G9a/KMT1C
BRD4770 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6288 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | info@chemia-pharm.com | CHINA | 310 | 58 | |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9976 | 58 |
View Lastest Price from BRD4770 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-02 | BRD4770
1374601-40-7
|
$38.00-118.00 | 99.53% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-02 | Methyl 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate
1374601-40-7
|
$1.00 | 1KG | Min98% HPLC | Career Henan Chemical Co |
-
- BRD4770
1374601-40-7
- $38.00-118.00
- 99.53%
- TargetMol Chemicals Inc.
-
- Methyl 2-(benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylate
1374601-40-7
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
