GSK2190915
- CAS No.
- 936350-00-4
- Chemical Name:
- GSK2190915
- Synonyms
- fiboflapon;AM 803;GSK2190915;GSK2190915 (AM803);Fiboflapon (GSK2190915);Fiboflapon, 10 mM in DMSO;AM-803;FIBOFLAPON;GSK-2190915;3-(3-(tert-Butylthio)-1-(4-(6-ethoxypyridin-3-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid;1H-Indole-2-propanoic acid, 3-[(1,1-dimethylethyl)thio]-1-[[4-(6-ethoxy-3-pyridinyl)phenyl]methyl]-α,α-dimethyl-5-[(5-methyl-2-pyridinyl)methoxy]-;3-[(1,1-Dimethylethyl)thio]-1-[[4-(6-ethoxy-3-pyridinyl)phenyl]methyl]-alpha,alpha-dimethyl-5-[(5-methyl-2-pyridinyl)methoxy]-1H-indole-2-propanoic acid
- CBNumber:
- CB02735522
- Molecular Formula:
- C38H43N3O4S
- Molecular Weight:
- 637.83
- MDL Number:
- MOL File:
- 936350-00-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 796.3±60.0 °C(Predicted) |
|---|---|
| Density | 1.16±0.1 g/cm3(Predicted) |
| solubility | DMSO: soluble; Methanol: soluble |
| form | A crystalline solid |
| pka | 4.70±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | Y1NA96IX3T |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
GSK2190915 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28600 | GSK2190915 ≥98% | 936350-00-4 | 1mg | $121 | 2026-04-30 | Buy |
| ChemScene | CS-3604 | Fiboflapon 99.50% | 936350-00-4 | 5mg | $164 | 2026-06-04 | Buy |
| ChemScene | CS-3604 | Fiboflapon 99.50% | 936350-00-4 | 10mg | $273 | 2026-06-04 | Buy |
| ChemScene | CS-3604 | Fiboflapon 99.50% | 936350-00-4 | 25mg | $542 | 2026-06-04 | Buy |
| ChemScene | CS-3604 | Fiboflapon 99.50% | 936350-00-4 | 50mg | $845 | 2026-06-04 | Buy |
GSK2190915 Chemical Properties, Uses, Production
Uses
Fiboflapon (GSK2190915; AM-803) is a potent and orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood[1].
Definition
ChEBI: Fiboflapon is a phenylpyridine.
in vivo
Oral administration of Fiboflapon (AM-803: 1 mg/kg) results in sustained inhibition of ex vivo ionophore-challenged whole blood LTB4 biosynthesis with >90% inhibition for up to 12 h and an EC50 of approximately 7 nM. When rat lungs are challenged in vivo with calcium-ionophore, Fiboflapon (AM-803) inhibits LTB4 and cysteinyl leukotriene (CysLT) production with ED50s of 0.12 mg/kg and 0.37 mg/kg, respectively. The inhibition measured 16 h following a single oral dose of 3 mg/kg was 86% and 41% for LTB4 and CysLTs, respectively. In an acute inflammation setting, Fiboflapon dose-dependently reduced LTB4, CysLTs, plasma protein extravasation and neutrophil influx induced by peritoneal zymosan injection. Finally, Fiboflapon increases survival time in mice exposed to a lethal intravenous injection of platelet activating factor (PAF)[1].
IC 50
LTB4: 76 nM (IC50)
References
[1] Stock NS, et al. 5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once DOI:10.1021/jm2008369
[2] Lorrain DS, et al. Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. Eur J Pharmacol. 2010 Aug 25;640(1-3):211-8. DOI:10.1016/j.ejphar.2010.05.003
GSK2190915 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK2190915 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai XingMo Biotechnology Co., Ltd. | +86 13524779951; 13524779951 | 2075692521@qq.com | China | 294 | 55 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3853 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1711 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4648 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
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