1-Bromo-cyclobutanecarboxylic acid ethyl ester
- CAS No.
- 35120-18-4
- Chemical Name:
- 1-Bromo-cyclobutanecarboxylic acid ethyl ester
- Synonyms
- Ethyl 1-bromocyclobutane-1-carboxylate;ETHYL 1-BROMOCYCLOBUTANECARBOXYLATE;NSC 135010;1-Bromo-1-carbethoxycyclobutane;1-Ethoxycarbonyl-1-bromocyclobutane;Ethyl1-bromocyclobutanecarboxylate,95%;ethyl alpha-bromocyclobutanecarboxylate;Ethyl 1-bromocyclobutanecarboxylate,96%;1-Bromocyclobutanecarboxylic acid ethyl;Ethyl 1-broMocyclobutanecarboxylate 96%
- CBNumber:
- CB0288831
- Molecular Formula:
- C7H11BrO2
- Molecular Weight:
- 207.07
- MDL Number:
- MFCD00001322
- MOL File:
- 35120-18-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 85-88 °C12 mm Hg(lit.) |
|---|---|
| Density | 1.279 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 175 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| color | Clear colorless |
| Stability | Light Sensitive |
| InChI | 1S/C7H11BrO2/c1-2-10-6(9)7(8)4-3-5-7/h2-5H2,1H3 |
| InChIKey | UTVNSHXHFRIXMM-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1(Br)CCC1 |
| CAS DataBase Reference | 35120-18-4 |
| FDA UNII | AX1RMD8FYJ |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 |
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter |
| Hazard Codes | C |
| Risk Statements | 34 |
| Safety Statements | 26-27-36/37/39-45 |
| RIDADR | UN 3265 8/PG 2 |
| WGK Germany | 3 |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29162000 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) |
1-Bromo-cyclobutanecarboxylic acid ethyl ester price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 197297 | Ethyl 1-bromocyclobutanecarboxylate 96% | 35120-18-4 | 5g | $111 | 2023-01-07 | Buy |
| TCI Chemical | E1245 | Ethyl 1-Bromocyclobutanecarboxylate >96.0%(GC) | 35120-18-4 | 1g | $34 | 2026-04-30 | Buy |
| TCI Chemical | E1245 | Ethyl 1-Bromocyclobutanecarboxylate >96.0%(GC) | 35120-18-4 | 5g | $135 | 2026-04-30 | Buy |
| TRC | TRC-E900295-5G | Ethyl 1-Bromocyclobutanecarboxylate | 35120-18-4 | 5g | $167 | 2026-06-03 | Buy |
| TRC | TRC-E900295-25G | Ethyl 1-Bromocyclobutanecarboxylate | 35120-18-4 | 25g | $644 | 2026-06-03 | Buy |
1-Bromo-cyclobutanecarboxylic acid ethyl ester Chemical Properties, Uses, Production
Chemical Properties
Clear colorless liquid
Uses
Ethyl 1-bromocyclobutanecarboxylate was used in the synthesis of 1aminocyclobutane carboxylic acid.
Synthesis
14924-53-9
35120-18-4
To a solution of ethyl cyclobutanecarboxylate (10 g) in carbon tetrachloride (100 mL) was sequentially added N-bromosuccinimide (NBS, 20.83 g) and azobisisobutyronitrile (AIBN, 1.281 g). The reaction mixture was stirred at 80 °C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (50 mL) and the mixture was extracted with ethyl acetate (3 x 50 mL). The organic phases were combined and washed sequentially with saturated sodium bicarbonate solution (50 mL), water (50 mL) and saturated saline (50 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=100:1) to afford the target product ethyl 1-bromocyclobutanecarboxylate (10 g) as a yellow oil.1H NMR (400MHz, CDCl3) δ: 4.26 (q, J=14.4,7.2Hz, 2H), 2.95-2.88 (m, 2H), 2.67- 2.59 (m, 2H), 2.26-2.21 (m, 1H), 1.91-1.86 (m, 1H), 1.32 (t, J=7.2Hz, 3H).
References
[1] Journal of Organic Chemistry, 2012, vol. 77, # 23, p. 11002 - 11005
[2] Chemical Communications, 2015, vol. 51, # 42, p. 8773 - 8776
[3] Organic Letters, 2016, vol. 18, # 9, p. 2040 - 2043
[4] Patent: WO2018/15411, 2018, A1. Location in patent: Paragraph 0165; 0166; 0167; 0168; 0169; 0170
[5] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 11, p. 988 - 993
1-Bromo-cyclobutanecarboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Suzhou Chukai PharmaTech | 0512-88812066 | wenlongfcb@qq.com | China | 110 | 62 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
View Latest Price from 1-Bromo-cyclobutanecarboxylic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-27 | ethyl 1-bromocyclobutane-1-carboxylate
35120-18-4
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-04-04 | 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
35120-18-4
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-08-11 | 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
35120-18-4
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- ethyl 1-bromocyclobutane-1-carboxylate
35120-18-4
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
35120-18-4
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 1-BROMO-CYCLOBUTANECARBOXYLIC ACID ETHYL ESTER
35120-18-4
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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