L-Methionine methyl ester hydrochloride
- CAS No.
- 2491-18-1
- Chemical Name:
- L-Methionine methyl ester hydrochloride
- Synonyms
- (S)-Methyl 2-aMino-4-(Methylthio)butanoate hydrochloride;H-Met-OMeCl;Met-OMe.HCl;H-MET-OME HCL;H-MET-OME·HCL;L-Met-Ome·HCl;H-L-Met-OMe*HCl;H-Met-OMea€￠ HCl;METHIONINE-OME HCL;H-MET-OME HYDROCHLORIDE
- CBNumber:
- CB0290878
- Molecular Formula:
- C6H14ClNO2S
- Molecular Weight:
- 199.7
- MDL Number:
- MFCD00012491
- MOL File:
- 2491-18-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| L-Methionine methyl ester hydrochloride 98% | 860409 | 25g | $263 |
| L-Methionine Methyl Ester Hydrochloride >96.0%(T) | M0853 | 5g | $26 |
| L-Methionine Methyl Ester Hydrochloride | 453377 | 10g | $355 |
| L-Methionine Methyl Ester Hydrochloride | 453377 | 25g | $502 |
| L-Methionine methyl ester hydrochloride Asreported | 283791 | 25g | $337 |
| More product size | |||
| Melting point | 151-153 °C(lit.) |
|---|---|
| alpha | 26 º (c=5, H2O 24 ºC) |
| refractive index | 26 ° (C=1, H2O) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| color | White to beige |
| optical activity | [α]22/D +25.9°, c = 1 in H2O |
| Water Solubility | Soluble in water. |
| Sensitive | Hygroscopic |
| BRN | 3913214 |
| Major Application | peptide synthesis |
| InChI | InChI=1/C6H13NO2S.ClH/c1-9-6(8)5(7)3-4-10-2;/h5H,3-4,7H2,1-2H3;1H/t5-;/s3 |
| InChIKey | MEVUPUNLVKELNV-USHJBNIQNA-N |
| SMILES | [C@H](N)(CCSC)C(=O)OC.Cl |&1:0,r| |
| CAS DataBase Reference | 2491-18-1(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P362+P364 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
L-Methionine methyl ester hydrochloride price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 860409 | L-Methionine methyl ester hydrochloride 98% | 2491-18-1 | 25g | $263 | 2026-04-30 | Buy |
| TCI Chemical | M0853 | L-Methionine Methyl Ester Hydrochloride >96.0%(T) | 2491-18-1 | 5g | $26 | 2026-04-30 | Buy |
| Usbiological | 453377 | L-Methionine Methyl Ester Hydrochloride | 2491-18-1 | 10g | $355 | 2026-06-03 | Buy |
| Usbiological | 453377 | L-Methionine Methyl Ester Hydrochloride | 2491-18-1 | 25g | $502 | 2026-06-03 | Buy |
| Usbiological | 283791 | L-Methionine methyl ester hydrochloride Asreported | 2491-18-1 | 25g | $337 | 2026-06-03 | Buy |
L-Methionine methyl ester hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Crystalline
Uses
L-Methionine methyl ester hydrochloride is used as a starting material for the synthesis of a protected glycine derivative, a versatile asymmetric building block.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
67-56-1
63-68-3
2491-18-1
Synthesis Example 1: L-methionine (0.5 g, 1 eq.) was suspended in a 100 mL round-bottomed flask fitted with a magnetic stirrer, methanol (30 mL, concentration 0.1 M) was added and cooled to 0°C under nitrogen atmosphere. Thionyl chloride (0.5 mL, 2 equiv.) was added slowly and dropwise to the above suspension, followed by heating and refluxing the reaction for 16 hours. After completion of the reaction, the solvent was removed by rotary evaporator to give a light yellow solid. The solid was ground with hot ether and the ether solution was removed by filtration to give a white solid L-methionine methyl ester hydrochloride (0.65561 g, 98% yield). The product was further purified by vacuum drying.1H NMR (D2O, 500 MHz) δH: 4.24 (1H, m, CH), 3.79 (3H, s, OCH3), 2.63 (2H, t, CH2), 2.25 (1H, m, CH2), 2.16 (1H, m, CH2), 2.06 (1H, s, SCH3). 13C NMR (D2O, 125 MHz) δC: 170.58 (C=O), 53.64 (OCH3), 51.70 (CH), 28.71 (CH2), 28.41 (CH2), 13.85 (SCH3). IR (neat, vmax, cm-1): 2880.8/2676.2 (CH3, CH2, CH), 2016.2, 1742.2 (C=O, ester), 1483.6, 1443.5, 1227, 1194.7, 1149.8, 1079.5 (C-O). HRMS m/z (+ESI): C6H14NO2S, calculated mass = 164.074 (error = 0.07 ppm).
References
[1] Journal of Organic Chemistry, 2011, vol. 76, # 1, p. 201 - 215
[2] Journal of the American Chemical Society, 2017, vol. 139, # 40, p. 14077 - 14089
[3] Patent: WO2012/131313, 2012, A1. Location in patent: Page/Page column 49
[4] Patent: US2014/39200, 2014, A1. Location in patent: Paragraph 0376-0380
[5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 8, p. 1942 - 1944
L-Methionine methyl ester hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9322 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-15680023009 | ni@enlaibio.com | China | 1103 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 | sales@amoychem.com | China | 6339 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17339 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| RongNa Biotechnology Co.,Ltd | +86-86-13583358881 +8618560316533 | Brad@rongnabiotech.com | China | 3374 | 58 |
View Lastest Price from L-Methionine methyl ester hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-03 | L-Methionine methyl ester hydrochloride
2491-18-1
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-03 | L-Met-OMe.HCl
2491-18-1
|
100kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-03-20 | L-Methionine methyl ester hydrochloride
2491-18-1
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- L-Methionine methyl ester hydrochloride
2491-18-1
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- L-Met-OMe.HCl
2491-18-1
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- L-Methionine methyl ester hydrochloride
2491-18-1
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
