SIB 1553A hydrochloride
- CAS No.
- 191611-89-9
- Chemical Name:
- SIB 1553A hydrochloride
- Synonyms
- SIB 1553A,SIB1553A;SIB 1553A hydrochloride;SIB 1553A Hyrdrochloride;SIB 1553A hydrochloride, nAChR agonist;4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol;4-((2-(1-Methylpyrrolidin-2-yl)ethyl)thio)phenol hydrochloride;4-[2-(1-methylpyrrolidin-2-yl)ethylsulfanyl]phenol:hydrochloride;(±)-4-[[2-(1-Methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride
- CBNumber:
- CB03037533
- Molecular Formula:
- C13H20ClNOS
- Molecular Weight:
- 273.82
- MDL Number:
- MOL File:
- 191611-89-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 149-151°C |
|---|---|
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | DMSO (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble to 100 mM in water |
| FDA UNII | JV7CWP9EAF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
SIB 1553A hydrochloride price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14973 | SIB 1553A (hydrochloride) ≥98% | 191611-89-9 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 14973 | SIB 1553A (hydrochloride) ≥98% | 191611-89-9 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 14973 | SIB 1553A (hydrochloride) ≥98% | 191611-89-9 | 10mg | $202 | 2026-04-30 | Buy |
| Cayman Chemical | 14973 | SIB 1553A (hydrochloride) ≥98% | 191611-89-9 | 50mg | $797 | 2026-04-30 | Buy |
| Usbiological | 256662 | SIB 1553A hydrochloride Asreported | 191611-89-9 | 10mg | $432 | 2026-06-03 | Buy |
SIB 1553A hydrochloride Chemical Properties, Uses, Production
Description
SIB 1553A is an agonist of nicotinic acetylcholine receptors (nAChRs) that displays selectivity for β4 subunit-containing receptors. Formulations containing SIB 1553A improve attentional function and performance in spatial and non-spatial working memory tasks in animals.
Uses
SIB 1553A hyrdrochloride is a novel cognitive enhancer with selectivity for neuronal nicotinic acetylcholine receptors (nAChR).
in vivo
SIB-1553A (1-40 mg/kg; s.c.) produces dose-dependent increases in ACh levels[3].
| Animal Model: | Male Sprague-Dawley rats (200-250 g)[3] |
| Dosage: | 1, 2, 4, 10, 20 and 40 mg/kg |
| Administration: | s.c. |
| Result: | Induced hippocampal ACh release. |
References
[1] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
[2] J S SCHNEIDER. The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.[J]. Journal of Pharmacology and Experimental Therapeutics, 2003, 306 1: 401-406. DOI: 10.1124/jpet.103.051912
[3] TERRY A, RISBROUGH V, BUCCAFUSCO J, et al. Effects of (+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride (SIB-1553A), a selective ligand for nicotinic acetylcholine receptors, in tests of visual attention and distractibility in rats and monkeys.[J]. The Journal of Pharmacology and Experimental Therapeutics, 2002, 264 1: 0. DOI: 10.1124/jpet.301.1.284
SIB 1553A hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
SIB 1553A hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2377 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
View Latest Price from SIB 1553A hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | SIB-1553A hydrochloride
191611-89-9
|
$35.00-179.00 | 99.89% | 10g | TargetMol Chemicals Inc. |
-
- SIB-1553A hydrochloride
191611-89-9
- $35.00-179.00
- 99.89%
- TargetMol Chemicals Inc.
