BC2059
- CAS No.
- 1227637-23-1
- Chemical Name:
- BC2059
- Synonyms
- Tegavivint;Tegoprazan D6;BC2059;BC-2059 Te atrabetan;Tegatrabetan (BC2059);BC-2059;BC2059;TEGAVIVINT;Tegatrabetan, 10 mM in DMSO;Tegatrabetan (BC-2059) ，S0733;TEGATRABETAN;BC-2059;TEGAVIVINT;Tegatrabetan,inhibit,Inhibitor,β-catenin,BC-2059,Beta catenin,BC 2059
- CBNumber:
- CB03038499
- Molecular Formula:
- C28H36N4O6S2
- Molecular Weight:
- 588.74
- MDL Number:
- MOL File:
- 1227637-23-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 287 °C(Solvent: Dichloromethane; Hexane) |
|---|---|
| Boiling point | 757.6±70.0 °C(Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO: 125 mg/mL (212.32 mM) |
| pka | 10.07±0.20(Predicted) |
| form | Solid |
| color | White to light yellow |
| InChIKey | LQQUOMJXUXVPRB-IOTKHNBZSA-N |
| SMILES | [S](=O)(=O)(N5C[C@H](C[C@H](C5)C)C)c1cc2c(cc1)C(c3c(cc(cc3)[S](=O)(=O)N4C[C@H](C[C@H](C4)C)C)C2N=O)N=O |
| FDA UNII | 18AP231HUP |
| NCI Drug Dictionary | tegavivint |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
BC2059 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37423 | Tegatrabetan ≥98% | 1227637-23-1 | 5mg | $110 | 2026-04-30 | Buy |
| Cayman Chemical | 37423 | Tegatrabetan ≥98% | 1227637-23-1 | 10mg | $209 | 2026-04-30 | Buy |
| Cayman Chemical | 37423 | Tegatrabetan ≥98% | 1227637-23-1 | 25mg | $469 | 2026-04-30 | Buy |
| Biosynth | CZB63723 | BC2059 | 1227637-23-1 | 5mg | $324.5 | 2026-06-04 | Buy |
| Biosynth | CZB63723 | BC2059 | 1227637-23-1 | 10mg | $389.4 | 2026-06-04 | Buy |
BC2059 Chemical Properties,Uses,Production
Uses
Tegatrabetan (BC2059) is a β-Catenin antagonist. Tegatrabetan disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1)[1].
Biological Activity
Tegatrabetan (BC2059) is a beta-Catenin antagonist. It disrupts β-catenin binding to scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and reduces β-catenin nuclear levels.
in vivo
Tegatrabetan (BC2059; 1.0 or 5.0 mg/kg/day; intravenously) significantly improves the median survival of the mice from approximately 17.5 to 39 days. Treatment with Tegatrabetan (10 mg/kg/day; intravenously) alone further improves the median survival to 51.5 days.
| Animal Model: | NOD/SCID mice bearing OCI-AML3 xenografts | < /tr>
| Dosage: | 1 mg/kg; 5 mg/kg; 10 mg/kg |
| Administration: | Intravenously; 1 mg/kg daily 4 days per week or 5 mg/kg or 10 mg/kg of BC2059 twice per week (Tuesday and Thursday) for 3 weeks. |
| Result: | Treatment significantly improved survival of NOD/SCID mice bearing OCI-AML3 xenografts. |
target
| Target | Value |
| β-catenin () |
References
[1] Fiskus W, et al. Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells. Leukemia. 2015 Jun;29(6):1267-78. DOI:10.1038/leu.2014.340
BC2059 Preparation Products And Raw materials
Raw materials
Preparation Products
BC2059 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7909 | 65 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9796 | 55 |
| Jiangsu aikang biomedical research and development co., LTD | 025-58859352 17714375163 | qzhang@aikonchem.com | China | 15525 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
