Pracinostat Dihydrochloride
- CAS No.
- 929016-98-8
- Chemical Name:
- Pracinostat Dihydrochloride
- Synonyms
- Fezolinetant NO;Fezolinetant HCl;Pracinostat Hydrochloride;Pracinostat Dihydrochloride
- CBNumber:
- CB03067572
- Molecular Formula:
- C20H32Cl2N4O2
- Molecular Weight:
- 431.4
- MDL Number:
- MOL File:
- 929016-98-8.mol
- MSDS File:
- SDS
| InChI | InChI=1S/C20H30N4O2.ClH/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3;/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25);1H/b12-10+; |
|---|---|
| InChIKey | RCLMPSZFYQJPQD-VHPXAQPISA-N |
| SMILES | C(N1C(=NC2=CC(/C=C/C(=O)NO)=CC=C12)CCCC)CN(CC)CC.Cl |
| FDA UNII | 83VNE45KXX |
Pracinostat Dihydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| DC Chemicals | DC60118 | Fezolinetant HCl >98% | 929016-98-8 | 100mg | $600 | 2026-05-24 | Buy |
| DC Chemicals | DC60118 | Fezolinetant HCl >98% | 929016-98-8 | 250mg | $1100 | 2026-05-24 | Buy |
| DC Chemicals | DC60118 | Fezolinetant HCl >98% | 929016-98-8 | 1g | $2000 | 2026-05-24 | Buy |
Pracinostat Dihydrochloride Chemical Properties, Uses, Production
Description
Pracinostat Dihydrochloride is a potent histone deacetylase (HDAC) inhibitor with an IC50 of 40-140 nM, used in cancer research. It also inhibits the activity of metallo-β-lactamase structural domain-containing protein 2 (MBLAC2) hydrolase with an EC50 of less than 10 nM.
Uses
Pracinostat dihydrochloride is a potent histone deacetylase (HDAC) inhibitor, with IC50s of 40-140 nM, used for cancer research. Pracinostat dihydrochloride also inhibits metallo-β-lactamase domain-containing protein2 (MBLAC2) hydrolase activity with an EC50 below 10 nM[1][4].
References
[1] Novotny-Diermayr V, et al. SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer. Mol Cancer Ther. 2010 Mar;9(3):642-52. DOI:10.1158/1535-7163.MCT-09-0689
[2] Wang H, et al. Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. J Med Chem. 2011 Jul 14;54(13):4694-720. DOI:10.1021/jm2003552
[3] Novotny-Diermayr V, et al. The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AML. Blood Cancer J. 2012 May;2(5):e69. DOI:10.1038/bcj.2012.14
[4] Lechner S, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Aug;18(8):812-820. DOI:10.1038/s41589-022-01015-5
Pracinostat Dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Pracinostat Dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
| Shanghai Shanyuan pharmaceutical technology co., LTD | 021-31761238 13167072949 | 3146446224@qq.com | China | 1420 | 55 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| Dideu Industries Group Limited | +8617392712697 | 1022@dideu.com | China | 29089 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9869 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Olix ( Hubei) Pharmaceutical Technology Co., Ltd | 17316404525 17316404525 | 209533805@qq.com | China | 9769 | 58 |
