YKL-05-099
- CAS No.
- 1936529-65-5
- Chemical Name:
- YKL-05-099
- Synonyms
- YKL-05-099;YKL-05-099, 10 mM in DMSO;YKL05099,YKL 05 099,inhibit,Salt-inducible Kinase (SIK),Inhibitor;3-(2-Chloro-6-methylphenyl)-7-((2-methoxy-4-(1-methylpiperidin-4-yl)phenyl)amino)-1-(5-methoxypyridin-2-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one;Pyrimido[4,5-d]pyrimidin-2(1H)-one, 3-(2-chloro-6-methylphenyl)-3,4-dihydro-7-[[2-methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-1-(5-methoxy-2-pyridinyl)-
- CBNumber:
- CB03147616
- Molecular Formula:
- C32H34ClN7O3
- Molecular Weight:
- 600.11
- MDL Number:
- MOL File:
- 1936529-65-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 761.0±70.0 °C(Predicted) |
|---|---|
| Density | 1.311±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO:103.33(Max Conc. mg/mL);172.18(Max Conc. mM) |
| form | A solid |
| pka | 8.63±0.20(Predicted) |
| color | White to light yellow |
| InChIKey | VQINULODWGEVBB-UHFFFAOYSA-N |
| SMILES | CC1=CC=CC(Cl)=C1N2C(N(C3=CC=C(OC)C=N3)C4=NC(NC5=C(OC)C=C(C6CCN(C)CC6)C=C5)=NC=C4C2)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P305+P351+P338-P332+P313-P362+P364-P337+P313 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
YKL-05-099 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3813 | YKL-05-099 ≥98% (HPLC) | 1936529-65-5 | 5 mg | $214 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3813 | YKL-05-099 ≥98% (HPLC) | 1936529-65-5 | 25 mg | $856 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3813 | YKL-05-099 ≥98% (HPLC) | 1936529-65-5 | 1 unit | $189.05 | 2025-07-31 | Buy |
| Cayman Chemical | 36116 | YKL-05-099 ≥98% | 1936529-65-5 | 5mg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 36116 | YKL-05-099 ≥98% | 1936529-65-5 | 10mg | $304 | 2026-04-30 | Buy |
YKL-05-099 Chemical Properties, Uses, Production
Uses
YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 binds to SIK1 and SIK3 with IC50s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC50=40 nM)[1].
Biological Activity
Potent and selective salt-inducible kinases (SIK1, SIK2, SIK3) inhibitor in vitro and in vivo.
YKL-05-099 is a potent and selective salt-inducible kinases inhibitor (SIK1/2/3 IC50 = 10/40/30 nM) with superior pharmacokinetic properties than HG-9-91-01. YKL-05-099 pre-treatment of murine BDMCs up-regulates Zymosan A-stimulated IL-10 (EC50 = 460 nM with 24h ), while suppresses inflammatory cytokines production (TNFα, IL-6 and IL-12p40). Likewise, YKL-05-099 intraperitoneal administration in mice (20 mg/kg i.p.) 15 min prior to LPS (0.5 mg/kg i.p.) enhances serum IL-10, while reduces HDAC5 pSer259 levels in total splenic leukocytes and serum TNFα level in vivo.
in vivo
YKL-05-099 is non-toxic at concentrations less than 10 μM and stable in mouse liver microsomes for more than 2 hours. YKL-05-099 is highly soluble (PBS solubility=428 μM) and present in an unbound state at appreciable levels in mouse plasma. YKL-05-099 dose dependently decreases phosphorylation of HDAC5 at the SIK-regulated site Ser259; reduced phosphorylation is observed at the lowest dose (5 mg/Kg) and is below the limit of detection by immunoblotting beginning at the 20 mg/Kg dose. YKL-05-099 dose-dependently reduces abundance of TNFα in serum beginning at 5 mg/Kg, and increases IL-10 levels at the 20 mg/Kg dose by more than 2-fold[1].
IC 50
SIK1; SIK3
References
[1] Sundberg TB, et al. Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. ACS Chem Biol. 2016 Aug 19;11(8):2105-11. DOI:10.1021/acschembio.6b00217
YKL-05-099 Preparation Products And Raw materials
Raw materials
Preparation Products
YKL-05-099 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemCell Biomedicine Co.,Ltd. | 020-13556033878 2965585218 13556033878 | chemcell@hotmail.com | China | 369 | 52 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Chengdu Senior Pharma Technology Co.Ltd. | +86-0838-2319818 +86-15982001943 | seniorpharma@163.com | China | 460 | 55 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1782 | 58 |
| Zhengzhou Acme Chemical Co., Ltd. | 037163312495 13303845143 | 1416159398@qq.com | China | 10150 | 58 |
View Latest Price from YKL-05-099 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | YKL-05-099
1936529-65-5
|
$68.00-189.00 | 99.89% | 10g | TargetMol Chemicals Inc. |
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- YKL-05-099
1936529-65-5
- $68.00-189.00
- 99.89%
- TargetMol Chemicals Inc.
