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ChemicalBook >> CAS DataBase List >>N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Structure
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide structure
CAS No.
702675-74-9
Chemical Name:
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
Synonyms
BX 795;CS-544;BX795, >97%;BX795/BX-795;BX 795, >=98%;BX-795 ，S1274;BX-795 hydrochloride;BX795, 10 mM in DMSO;BX-795; BX 795; BX795.;BX-795 - CAS 702675-74-9 - Calbiochem
CBNumber:
CB42484697
Molecular Formula:
C23H26IN7O2S
Molecular Weight:
591.47
MDL Number:
MFCD12546134
MOL File:
702675-74-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Properties

Melting point >163°C (dec.)
Density 1.644
storage temp. 2-8°C
solubility DMSO: soluble15mg/mL, clear
form powder
pka 12.57±0.70(Predicted)
color white to light brown
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey VAVXGGRQQJZYBL-UHFFFAOYSA-N
SMILES Cl.Ic1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)c4cccs4
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501
WGK Germany  3
Storage Class 11 - Combustible Solids

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide price More Price(75)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0694 BX-795 hydrochloride ≥98% (HPLC) 702675-74-9 5mg $121 2026-04-30 Buy
Sigma-Aldrich 204001 BX-795 702675-74-9 10mg $247 2026-04-30 Buy
Cayman Chemical 14932 BX-795 ≥98% 702675-74-9 5mg $90 2026-04-30 Buy
Cayman Chemical 14932 BX-795 ≥98% 702675-74-9 10mg $168 2026-04-30 Buy
Cayman Chemical 14932 BX-795 ≥98% 702675-74-9 25mg $349 2026-04-30 Buy
Product number Packaging Price Buy
SML0694 5mg $121 Buy
204001 10mg $247 Buy
14932 5mg $90 Buy
14932 10mg $168 Buy
14932 25mg $349 Buy

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Chemical Properties, Uses, Production

Description

3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX-795 is a potent, ATP-competitive inhibitor of PDK1 in vitro (IC50 = 11 nM) and in cells (IC50 = 300 nM). At comparable concentrations, BX-795 also inhibits ERK8, MAPK-interacting kinase 2, Aurora B, Aurora C, MAP/microtubule affinity-regulating kinases 1-4, TNF receptor associated factor-associated NF-κB activator-binding kinase 1, IκB kinase ε, and additional kinases.

Uses

BX-795 hydrochloride has been used to study the effect of kinase inhibition on human endogenous retroviruses (HERVs) transcription activation.

Definition

ChEBI: N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide is a member of ureas.

Biochem/physiol Actions

BX-795 competes for the ATP (adenosine triphosphate) binding pocket of 3-phosphoinositide-dependent kinase-1 (PDK1) with its substrate ATP. In vitro assays reveal that BX-795 might inhibit Unc-51 (serine/threonine-protein kinase)-like autophagy activating kinase (ULK1).

storage

Store at -20°C

References

[1] RICHARD I FELDMAN. Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.[J]. The Journal of Biological Chemistry, 2005, 280 20: 19867-19874. DOI:10.1074/jbc.m501367200
[2] JENNY BAIN. The selectivity of protein kinase inhibitors: a further update.[J]. Biochemical Journal, 2007: 297-315. DOI:10.1042/bj20070797
[3] KRISTOPHER CLARK. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.[J]. The Journal of Biological Chemistry, 2009, 284 21: 14136-14146. DOI:10.1074/jbc.m109.000414
[4] LI-YUAN BAI . BX795, a TBK1 inhibitor, exhibits antitumor activity in human oral squamous cell carcinoma through apoptosis induction and mitotic phase arrest[J]. European journal of pharmacology, 2015, 769: Pages 287-296. DOI:10.1016/j.ejphar.2015.11.032
[5] EUN A CHOI . A pharmacogenomic analysis using L1000CDS2 identifies BX-795 as a potential anticancer drug for primary pancreatic ductal adenocarcinoma cells[J]. Cancer letters, 2019, 465: Pages 82-93. DOI:10.1016/j.canlet.2019.08.002
[6] SARAH A SCUDERI. TBK1 Inhibitor Exerts Antiproliferative Effect on Glioblastoma Multiforme Cells.[J]. Oncology Research, 2021, 28 7: 779-790. DOI:10.3727/096504021x16161478258040
[7] TOLGA SUTLU. Inhibition of intracellular antiviral defense mechanisms augments lentiviral transduction of human natural killer cells: implications for gene therapy.[J]. Human gene therapy, 2012, 23 10: 1090-1100. DOI:10.1089/hum.2012.080
[8] DAVID S J ALLAN. Systematic improvements in lentiviral transduction of primary human natural killer cells undergoing ex vivo expansion.[J]. Molecular Therapy. Methods & Clinical Development, 2021: 559-571. DOI:10.1016/j.omtm.2021.01.008
[9] PETER CHOCKLEY  Stephen G  Sagar L Patil. Transient blockade of TBK1/IKKε allows efficient transduction of primary human natural killer cells with vesicular stomatitis virus G-pseudotyped lentiviral vectors[J]. Cytotherapy, 2021, 23 9: Pages 787-792. DOI:10.1016/j.jcyt.2021.04.010
[10] LINGYU LI. Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795.[J]. Journal of Translational Medicine, 2020: 363. DOI:10.1186/s12967-020-02526-2

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Suppliers

Global Suppliers ( 214)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Wuhan TCASChem Technology Co., Ltd. 027-86697669 13986148687 sales@tcaschem.com China 3987 55
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
SYN|thesis med chem P/L +86-021-50720296 service@synkinase.com China 266 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
Jinan Trio PharmaTech Co., Ltd. 62
Dalian Meilun Biotech Co., Ltd. 58
Wuhan TCASChem Technology Co., Ltd. 55
Shanghai Topbiochem Technology Co., Ltd 58
Haoyuan Chemexpress Co., Ltd. 61
SYN|thesis med chem P/L 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65

View Latest Price from N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BX795 pictures 2026-07-27 BX795
702675-74-9
 $54.00-220.00 99.11% 10g TargetMol Chemicals Inc.
BX-795 pictures 2025-08-21 BX-795
702675-74-9
 1kg 99% HPLC 1000kg HangZhou RunYan Pharma Technology Co.,LTD.
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide pictures 2019-09-04 N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
702675-74-9
 $5.00 1KG 99% 1ton Career Henan Chemical Co
  • BX795 pictures
  • BX795
    702675-74-9
  • $54.00-220.00
  • 99.11%
  • TargetMol Chemicals Inc.
  • BX-795 pictures
  • BX-795
    702675-74-9
  • $0.00
  • 99% HPLC
  • HangZhou RunYan Pharma Technology Co.,LTD.

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Spectrum

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide(702675-74-9)1HNMR

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N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX 795 N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)aMino]propyl]aMino]-2-pyriMidinyl]aMino]phenyl]-1-pyrrolidin BX795/BX-795 N-(3-(5-IODO-4-(3-(THIOPHENE-2-CARBOXAMIDO)PROPYLAMINO)PYRIMIDIN-2-YLAMINO)PHENYL)PYRROLIDINE-1-CARBOXAMIDE N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX-795 BX-795 hydrochloride N-[3-[[5-iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-Pyrrolidinecarboxamide hydrochloride BX795N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX 795, >=98% BX-795; BX 795; BX795. CS-544 BX-795 - CAS 702675-74-9 - Calbiochem BX795, >97% N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrr 1-Pyrrolidinecarboxamide,N-[3-[[5-iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]- N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl]amino}pyrimidin-2-yl)amino]phenyl}pyrrolidine-1-carboxamide N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide USP/EP/BP IKK,Inhibitor,BX795,BX-795,I kappa B kinase,inhibit,IκB kinase,PDK-1,BX 795,Autophagy BX795, 10 mM in DMSO BX-795 ，S1274 702675-74-9 C23H26IN7O2S Inhibitors Akt mTOR PI3K API