Clodronate disodium Salt
- CAS No.
- 22560-50-5
- Chemical Name:
- Clodronate disodium Salt
- Synonyms
- CLODRONATE DISODIUM;DMDP;Loron;CL2MDP;bm06011;U-82067E;lodronate;Difosfonal;clodronatesodium;sodiumclodronate
- CBNumber:
- CB0318011
- Molecular Formula:
- CH5Cl2NaO6P2
- Molecular Weight:
- 268.88
- MDL Number:
- MFCD01632786
- MOL File:
- 22560-50-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >330°C |
|---|---|
| storage temp. | room temp |
| solubility | Freely soluble in water, practically insoluble in ethanol (96 per cent), slightly soluble in methanol. |
| form | Solid |
| color | White to Off-White |
| Water Solubility | water: 49.00-51.00mg/mL, clear, colorless |
| InChI | InChI=1S/CH4Cl2O6P2.Na.H/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);; |
| InChIKey | HJKBJIYDJLVSAO-UHFFFAOYSA-L |
| SMILES | C(Cl)(Cl)(P(O)(O)=O)P(O)(O)=O.[NaH] |
| CAS DataBase Reference | 22560-50-5(CAS DataBase Reference) |
| FDA UNII | Y05R4GCQ1H |
| NCI Drug Dictionary | clodronate disodium |
| UNSPSC Code | 12352106 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| RTECS | SZ7640700 |
| HS Code | 29319090 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | mouse,LD50,intraperitoneal,780mg/kg (780mg/kg),British UK Patent Application. Vol. #2096889, |
Clodronate disodium Salt price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D4434 | Dichloromethylenediphosphonic acid disodium salt | 22560-50-5 | 1g | $383 | 2026-04-30 | Buy |
| Usbiological | C5843-50 | Clodronic Acid, Disodium Salt, Tetrahydrate (Clodronate Disodium, Bonefos, Clasteon, Clastoban) ~90%| | 22560-50-5 | 5g | $538 | 2026-06-03 | Buy |
| TRC | TRC-C586875-5G | Clodronic Acid Disodium Salt Hydrate | 22560-50-5 | 5g | $280 | 2026-06-03 | Buy |
| TRC | TRC-C586875-50G | Clodronic Acid Disodium Salt Hydrate | 22560-50-5 | 50g | $2502 | 2026-06-03 | Buy |
| TRC | TRC-C586875-10G | Clodronic Acid Disodium Salt Hydrate | 22560-50-5 | 10g | $532 | 2026-06-03 | Buy |
Clodronate disodium Salt Chemical Properties,Uses,Production
Description
Clodronate disodium is a bone resorption inhibitor, useful as adjunct therapy in the treatment of osteolytic bone metastases and malignant hypercalcemia.
Chemical Properties
White Solid
Originator
Proctor & Gamble (USA)
Uses
Clodronic Acid Disodium Salt Hydrate is a bisphosphonate antiresorptive agent; bone resorption inhibitor.
Definition
ChEBI: The disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used (generally as the tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteoly ic lesions and bone pain associated with skeletal metastases.
brand name
Bonefos (Leiras Oy, Finland).
Hazard
Moderately toxic by ingestion.
Biochem/physiol Actions
Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.
Clinical Use
Bisphosphonate: Management of osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastases in patients with breast cancer or multiple myeloma
Safety Profile
A poison by intravenous route. Moderately toxic by ingestion, intraperitoneal routes. When heated to decomposition it emits toxic vapors of PO, and Cl-
Drug interactions
Potentially hazardous interactions with other drugs
Cytotoxics: concentration of estramustine increased.
Metabolism
Clodronate is not metabolised.
Over 70% of an intravenous dose is excreted unchanged
in the urine within 24 hours, the remainder being
sequestered to bone tissue. The substance which is bound
to bone is excreted more slowly, and the renal clearance is
about 75% of the plasma clearance.
Clodronate disodium Salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai XueEr Pharmaceutical Technology Co., Ltd | 021-34622192 13917187091 | 1021708276@qq.com | China | 81 | 57 |
| Beijing Stronger Science Co., Ltd. | 0531-88924771 15614660963 | elsa.hang@strongerscience.com | China | 10622 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6746 | 52 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7909 | 65 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
View Lastest Price from Clodronate disodium Salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | Clodronate disodium
22560-50-5
|
$1.00 | 1KG | 99% | 20 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-07-15 | Clodronic acid disodium salt
22560-50-5
|
$35.00-95.00 | 99.63% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-09-18 | Clodronate disodium
22560-50-5
|
$50.00 | 1Kg/Bag | 98% | 200kg/month | XI'AN TIANGUANGYUAN BIOTECH CO., LTD. |
-
- Clodronate disodium
22560-50-5
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Clodronic acid disodium salt
22560-50-5
- $35.00-95.00
- 99.63%
- TargetMol Chemicals Inc.
-
- Clodronate disodium
22560-50-5
- $50.00
- 98%
- XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
