Disodium clodronate tetrahydrate
- CAS No.
- 88416-50-6
- Chemical Name:
- Disodium clodronate tetrahydrate
- Synonyms
- Clodronate (sodium salt hydrate);Clodronate disodium tetrahydrate CRS;BONEFOS;CLASTEON;CLASTOBAN;Ceftobiprole Impurity 11;Disodium clodronate tetrahydrate;Clodronate disodium salt hydrate;Clodronate disodiuM(tetrehydrate);DisodiumClodronateTetrahydrate>
- CBNumber:
- CB4404653
- Molecular Formula:
- CH7Cl2NaO7P2
- Molecular Weight:
- 286.9
- MDL Number:
- MFCD02940846
- MOL File:
- 88416-50-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | 2-8°C |
|---|---|
| solubility | Soluble in Water (up to at least 10 mg/ml) |
| form | White solid |
| color | White |
| Water Solubility | water: 1mg/mL |
| Merck | 14,2371 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| InChI | 1S/CH4Cl2O6P2.2Na.4H2O/c2-1(3,10(4,5)6)11(7,8)9;;;;;;/h(H2,4,5,6)(H2,7,8,9);;;4*1H2/q;2*+1;;;;/p-2 |
| InChIKey | XWHPUCFOTRBMGS-UHFFFAOYSA-L |
| SMILES | [Na+].[Na+].[P](=O)([O-])(O)C([P](=O)([O-])O)(Cl)Cl.O.O.O.O |
| FDA UNII | N030400H8J |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361-H332-H412-H302 | |||||||||
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P273-P501-P201-P202-P281-P308+P313-P405-P501 | |||||||||
| WGK Germany | WGK 1 | |||||||||
| RTECS | SZ7640700 | |||||||||
| HS Code | 2931.39.0030 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Disodium clodronate tetrahydrate price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0000888 | Clodronate disodium tetrahydrate European Pharmacopoeia (EP) Reference Standard | 88416-50-6 | 5 mg | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | 233183 | Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem | 88416-50-6 | 10mg | $156 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0000888 | Clodronate disodium tetrahydrate European Pharmacopoeia (EP) Reference Standard | 88416-50-6 | y0000888 | $153 | 2024-03-01 | Buy |
| TCI Chemical | D4160 | Disodium Clodronate Tetrahydrate >98.0%(T) | 88416-50-6 | 1g | $86 | 2026-04-30 | Buy |
| TCI Chemical | D4160 | Disodium Clodronate Tetrahydrate >98.0%(T) | 88416-50-6 | 5g | $295 | 2026-04-30 | Buy |
Disodium clodronate tetrahydrate Chemical Properties, Uses, Production
Description
Bisphosphonates bind strongly to bone and reduce bone resorption through effects on both osteoclasts and osteoblasts. Clodronate is a non-nitrogenous bisphosphonate that has been used in the treatment of osteoporosis and other metabolic bone diseases. It binds to hydroxyapatite crystals with an affinity constant of 0.72 μM, inhibiting their growth (IC50 = 1.34 μM) and bone resorption. Clondronate is metabolized intracellularly to a β-γ-methylene analog of ATP that is cytotoxic to both osteoclasts and macrophages, which belong to the same cell lineage as osteoclasts. Liposome-encapsulated bisphosphonates such as clodronate have been used in biological research to selectively deplete macrophage-like cells and cancer cells.
Uses
Disodium Clodronate Tetrahydrate is a bisphosphonate bone growth regulator.
Definition
ChEBI: The tetrahydrate of the disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions nd bone pain associated with skeletal metastases.
in vivo
Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition[1].
Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition [1].
| Animal Model: | C57BL/6 mice (22-30 g)[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intravenous injection |
| Result: | Attenuated carrageenan- or complete Freund’s adjuvant (CFA)-evoked inflammatory pain. |
References
[1] G L PLOSKER K L G. Clodronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease.[J]. Drugs, 1994, 47 6: 945-982. DOI:10.2165/00003495-199447060-00007
[2] P. LEHENKARI. Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.[J]. Molecular Pharmacology, 2002, 61 5 1: 1255-1262. DOI:10.1124/mol.61.5.1255
Disodium clodronate tetrahydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Disodium clodronate tetrahydrate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai XueEr Pharmaceutical Technology Co., Ltd | 021-34622192 13917187091 | 1021708276@qq.com | China | 81 | 57 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
View Latest Price from Disodium clodronate tetrahydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | Disodium clodronate tetrahydrate
88416-50-6
|
10g | 98%-101% | 10KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2023-02-24 | Disodium clodronate tetrahydrate
88416-50-6
|
5g | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2021-07-09 | new Disodium clodronate tetrahydrate
88416-50-6
|
$7.00 | 1KG | 98% | 1000 Kilogram/Kilograms per Month Disodium clodronate tetrahydrate | Hebei Xibaijie Biotechnology Co., Ltd. |
-
- Disodium clodronate tetrahydrate
88416-50-6
- $0.00
- 98%-101%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Disodium clodronate tetrahydrate
88416-50-6
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- new Disodium clodronate tetrahydrate
88416-50-6
- $7.00
- 98%
- Hebei Xibaijie Biotechnology Co., Ltd.
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