CMP5
- CAS No.
- 1030021-40-9
- Chemical Name:
- CMP5
- Synonyms
- CMP5;CMP-5 hydrochloride;CMP-5 hydrochloride (PRMT5-IN-5);CMP 5 hydrochloride,CMP5 hydrochloride
- CBNumber:
- CB03364109
- Molecular Formula:
- C21H22ClN3
- Molecular Weight:
- 351.88
- MDL Number:
- MFCD07168944
- MOL File:
- 1030021-40-9.mol
| Product description | Number | Pack Size | Price |
| CMP5 99% | Axon2709 | 10mg | $104.5 |
CMP5 Chemical Properties,Uses,Production
Description
CMP5 is a potent and selective PRMT5 Inhibitor. CMP5 showed to occupy hPRMT5 catalytic site and block symmetrically dimethylated S2Me-H4R3 & S2Me-H3R8 with no effect on the asymmetric methylation of H4R3 in lymphoblastoid cell lines at 40 μM. CMP-5 shows promise as a novel therapeutic_x000D_ approach for B-cell lymphomas.
Uses
CMP-5 hydrochloride is a potent, specific, and selective PRMT5 inhibitor, while displays no activity against PRMT1, PRMT4, and PRMT7 enzymes. CMP-5 hydrochloride selectively blocks S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. CMP-5 hydrochloride prevents EBV-driven B-lymphocyte transformation but leaving normal B cells unaffected[1][2].
References
[1] Alinari L, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.Blood. 2015 Apr 16;125(16):2530-43. DOI:10.1182/blood-2014-12-619783
[2] Webb LM, et al. PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis. J Immunol.?2017?Feb 15;198(4):1439-1451. DOI:10.4049/jimmunol.1601702
CMP5 Preparation Products And Raw materials
Raw materials
Preparation Products
CMP5 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32436 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19961 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 989 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4834 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24961 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Guangzhou Yiran Biotechnology Co., Ltd. | 15571990006 | CHINA | 141 | 58 |
View Lastest Price from CMP5 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-07-18 | CMP-5 hydrochloride
1030021-40-9
|
US $2500.00-1980.00 / mg | 10g | TargetMol Chemicals Inc. |
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- CMP-5 hydrochloride
1030021-40-9
- US $2500.00-1980.00 / mg
- TargetMol Chemicals Inc.
