Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Structure
tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate structure
CAS No.
929252-65-3
Chemical Name:
tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate
Synonyms
1-Piperidinecarboxylic acid,4-[[[4-(4-amino-2-fluorophenoxy)...;6-Methoxy-7-(N-BOC-4-piperidinemethoxy)-4-(2-fluoro-4-amino-phenoxy)-quinoline;6-Methoxy-7- (N-BOC-4 piperidimethoxy) -4- (2-fluoro-4-amino phenoxy) - quinoline;tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 4-[[[4-(4-amino-2-fluorophenoxy)-6-methoxy-7-quinolinyl]oxy]methyl]-, 1,1-dimethylethyl ester
CBNumber:
CB03367685
Molecular Formula:
C27H32FN3O5
Molecular Weight:
497.56
MDL Number:
MOL File:
929252-65-3.mol
Last updated:2026-05-27 17:37:49
Request For Quotation

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Properties

Boiling point 619.7±55.0 °C(Predicted)
Density 1.235±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 5.42±0.30(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 295150 tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate 929252-65-3 250.00mg $52 2026-05-19 Buy
Matrix Scientific 295150 tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate 929252-65-3 1.00g $126 2026-05-19 Buy
Matrix Scientific 295150 tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate 929252-65-3 5.00g $517 2026-05-19 Buy
aablocks AA01FS3T tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate 97% 929252-65-3 250mg $36 2026-05-30 Buy
aablocks AA01FS3T tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate 97% 929252-65-3 1g $87 2026-05-30 Buy
Product number Packaging Price Buy
295150 250.00mg $52 Buy
295150 1.00g $126 Buy
295150 5.00g $517 Buy
AA01FS3T 250mg $36 Buy
AA01FS3T 1g $87 Buy

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Chemical Properties, Uses, Production

Synthesis

1-Piperidinecarboxylic acid, 4-[[[4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-quinolinyl]oxy]methyl]-, 1,1-dimethylethyl ester

849217-45-4

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate

929252-65-3

Step 4. Synthesis of tert-butyl 4-(((4-(4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate (81): to a mixture of ethanol (8 mL) and water (4 mL) of Compound 80 (0.50 g, 0.95 mmol) was added iron powder (0.254 g, 4.55 mmol) and ammonium chloride ( 0.123 g, 2.26 mmol). The reaction mixture was heated to reflux for 2 hours. After completion of the reaction, the reaction mixture was diluted with methanol and filtered to remove the solid suspension. The filtrate was concentrated and the resulting residue was purified by a Gilson automated purification system (eluent gradient: 35% to 57% methanol/dichloromethane) to afford the target product 4-(((4-(4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylic acid tert-butyl ester 81 (0.25 g, 52% yield).

References

[1] Patent: US2008/4273, 2008, A1. Location in patent: Page/Page column 79; 80
[2] Patent: US2007/60613, 2007, A1. Location in patent: Page/Page column 17-18

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

1-Piperidinecarboxylic acid, 4-[[[4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-quinolinyl]oxy]methyl]-, 1,1-dimethylethyl ester Iron Ammonium chloride Water Ethanol

Preparation Products

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate Suppliers

Global Suppliers ( 26)
Supplier Tel Email Country ProdList Advantage
SHANGHAI FDC-CHEMICAL CO.,LTD 021-61469567 13774476675 sales@fdc-chemical.com China 10000 58
Henan Alfachem Co.,Ltd. 0371-55051623 18137891487 3983243027@qq.com China 9989 58
Tianjin Zhongcheng Mingyuan Technology Co., Ltd. 13302022156 3506745780@qq.com China 168 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684; sales@rrkchem.com China 57330 58
Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418684 +86-18949823763 sales@tnjchem.com China 25333 58
Baoji Guokang Healthchem Co., Ltd. +86-0917-3909592 +86-13892490616 gksales1@gk-bio.com China 9028 58
Neostar United (Changzhou) Industrial Co., Ltd. +86-0519-85551759 marketing1@neostarunited.com China 8827 58
Wuhan Topule +86-02787215551 19945035818 2936752263@qq.com China 7955 58
Jinan Dexinjia Bio&Tech Co., Ltd 0531-82375818 15064153060 1329217348@qq.com China 1433 58
Guangzhou Yunmen Biotechnology Co., Ltd 0751-18902340975/189023400307 18902340307 3356812514@qq.com China 9225 58
Supplier Advantage
SHANGHAI FDC-CHEMICAL CO.,LTD 58
Henan Alfachem Co.,Ltd. 58
Tianjin Zhongcheng Mingyuan Technology Co., Ltd. 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Baoji Guokang Healthchem Co., Ltd. 58
Neostar United (Changzhou) Industrial Co., Ltd. 58
Wuhan Topule 58
Jinan Dexinjia Bio&Tech Co., Ltd 58
Guangzhou Yunmen Biotechnology Co., Ltd 58

View Latest Price from tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate pictures 2022-02-25 tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate
929252-65-3
 1KG 98% 100 Jinan Ande Pharmaceutical Co.,Ltd.

929252-65-3 (tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate) Related Search:

1-Piperidinecarboxylic acid, 4-[[[4-(2-fluoro-4-nitrophenoxy)-6-methoxy-7-quinolinyl]oxy]methyl]-, 1,1-dimethylethyl ester 1,4-Piperazinedicarboxylic acid, 2-methyl-, 1-[4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl] 4-(1,1-dimethylethyl) ester, (2R)- tert-butyl 4-((4-aMino-2-fluorophenoxy)Methyl)piperidine-1-carboxylate tert-Butyl 4-[(2-amino-6-fluorophenoxy)methyl]piperidine-1-carboxylate 1-Piperidinecarboxylic acid, 3-[(5-amino-2-fluorophenoxy)methyl]-, 1,1-dimethylethyl ester, (3R)-
1-Piperidinecarboxylic acid, 3-[(5-amino-2-fluorophenoxy)methyl]-, 1,1-dimethylethyl ester, (3S)-

1of2

tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate 1-Piperidinecarboxylic acid, 4-[[[4-(4-amino-2-fluorophenoxy)-6-methoxy-7-quinolinyl]oxy]methyl]-, 1,1-dimethylethyl ester 1-Piperidinecarboxylic acid,4-[[[4-(4-amino-2-fluorophenoxy)... 6-Methoxy-7-(N-BOC-4-piperidinemethoxy)-4-(2-fluoro-4-amino-phenoxy)-quinoline 6-Methoxy-7- (N-BOC-4 piperidimethoxy) -4- (2-fluoro-4-amino phenoxy) - quinoline 929252-65-3