2-Nitroimidazole
- CAS No.
- 527-73-1
- Chemical Name:
- 2-Nitroimidazole
- Synonyms
- 2-nitro-1h-imidazole;AZOMYCIN;2-Nitroimidazole sulfate;11a;amicin;ro05-9129;AZOMYCINE;2-NITROMIDAZOLE;2-nitro-imidazo;2-Nitroimidaxole
- CBNumber:
- CB0340968
- Molecular Formula:
- C3H3N3O2
- Molecular Weight:
- 113.07
- MDL Number:
- MFCD00005185
- MOL File:
- 527-73-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 287 °C (dec.) (lit.) |
|---|---|
| Boiling point | 211.75°C (rough estimate) |
| Density | 1.5988 (rough estimate) |
| refractive index | 1.4264 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | NH4OH: soluble50mg/mL, clear, yellow to orange |
| form | Powder |
| pka | 8.72±0.10(Predicted) |
| color | Light yellow to khaki-green |
| Water Solubility | insoluble |
| Merck | 14,921 |
| BRN | 116444 |
| InChI | 1S/C3H3N3O2/c7-6(8)3-4-1-2-5-3/h1-2H,(H,4,5) |
| InChIKey | YZEUHQHUFTYLPH-UHFFFAOYSA-N |
| SMILES | [O-][N+](=O)c1ncc[nH]1 |
| CAS DataBase Reference | 527-73-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | K8E96XL55D |
| EPA Substance Registry System | 1H-Imidazole, 2-nitro- (527-73-1) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 22-36/37/38-23/24/25-20/21/22 | |||||||||
| Safety Statements | 26-36-45-36/37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI7875000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29332990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| Toxicity | LD50 i.v. in mice: 80 mg/kg (Maeda) | |||||||||
| NFPA 704 |
|
2-Nitroimidazole price More Price(92)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 195650 | 2-Nitroimidazole 98% | 527-73-1 | 250mg | $57.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 195650 | 2-Nitroimidazole 98% | 527-73-1 | 1g | $93.8 | 2026-04-30 | Buy |
| TCI Chemical | N0891 | 2-Nitroimidazole >98.0%(HPLC)(T) | 527-73-1 | 1g | $62 | 2026-04-30 | Buy |
| TCI Chemical | N0891 | 2-Nitroimidazole >98.0%(HPLC)(T) | 527-73-1 | 5g | $245 | 2026-04-30 | Buy |
| Cayman Chemical | 29395 | Azomycin ≥98% | 527-73-1 | 500mg | $37 | 2026-04-30 | Buy |
2-Nitroimidazole Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Uses
2-Nitroimidazole is a antibiotic substance produced by an unidentified Streptomyces,it is used to prepare nitroimidazole substituted boronic acids as precursors for imaging hypoxic tissue 1.It is also used to prepare potential site-selective radiosensitizers for estrogen receptor-rich tumors.
Uses
2-Nitroimidazole, is used as an antibiotic in pharma industry.
Definition
ChEBI: An imidazole that is 1H-imidazole substituted at position 2 by a nitro group.
General Description
2-Nitroimidazole is a natural antibiotic.
Synthesis
42383-61-9
527-73-1
General procedure for the synthesis of 2-nitroimidazole from 2-aminoimidazole sulfate: 2-aminoimidazole sulfate (1.57 g, 6.01 mmol) was dissolved in water (10 mL) and 50% w/v fluoroboric acid (7 mL). The reaction solution was cooled to -20 °C in an acetone/dry ice bath and a solution of sodium nitrite (4.14 g, 59.6 mmol) in water (10 mL) was added slowly and dropwise. The reaction temperature was maintained at -10 °C and stirred for 30 min. Subsequently, the reaction solution was poured into a solution of copper sulfate (20.0 g, 119 mmol) in water (200 mL). Sodium nitrite (4.14 g, 59.6 mmol) was then added and the reaction mixture was stirred for 2 hours at room temperature. After completion of the reaction, the extract was carried out for 6 hours using a continuous extractor with ethyl acetate (200 mL) as the extractant. The organic phases were combined, concentrated under reduced pressure and the residue was recrystallized from ethanol to give the target compound 2-nitroimidazole as yellow needle-like crystals (870 mg, 65% yield).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 17, p. 5102 - 5106
2-Nitroimidazole Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Sanli Biological Technology Co., LTD | 18302763494; 18302763494 | love_lzj@petaimail.com | China | 26 | 58 |
| TaiZhou ZhiCheng Chemicals & Technology Co., LTD. | 0523-82837785 13914525028 | info@jszchg.com | China | 244 | 60 |
| Zhongxin Chenshi (Wuhan) Technology Co., Ltd | 18942922096 | 2662561040@qq.com | China | 980 | 58 |
| Henan Chongyi Biomedicine Co., Ltd | 18257818007 | 779340002@qq.com | China | 41 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd. | 13131120796 13131120796 | kelly@chuanghaibio.com | China | 985 | 58 |
| Weifu (Shanghai) Pharmaceutical Technology Co., LTD | 021-57609736 13917553503 | 401919639@qq.com | China | 246 | 58 |
| Shanghai Forholy Chemical Technology Co., LTD | 18616083375 | 305846338@qq.com | China | 19 | 58 |
| Hubei Yuanshan Biotechnology Co., Ltd | 13872992665 | 790195079@qq.com | China | 19 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
View Lastest Price from 2-Nitroimidazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 2-Nitroimidazole
527-73-1
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-08 | 2-Nitroimidazole
527-73-1
|
1kg | 98.5%min | 100kg ; 500kg | Hangzhou ICH Biofarm Co., Ltd | ||
 |
2026-05-28 | 2-Nitroimidazole
527-73-1
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2-Nitroimidazole
527-73-1
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-Nitroimidazole
527-73-1
- 98.5%min
- Hangzhou ICH Biofarm Co., Ltd
-
- 2-Nitroimidazole
527-73-1
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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