QDVBJHFEZRTDHU-QAQDUYKDSA-N
- CAS No.
- 1498300-35-8
- Chemical Name:
- QDVBJHFEZRTDHU-QAQDUYKDSA-N
- Synonyms
- QQN-00358;QDVBJHFEZRTDHU-QAQDUYKDSA-N;Cyclohexanecarboxylic acid, 4-[[1-[[2-cyano-3-(trifluoromethyl)phenyl]methyl]-1,4-dihydro-5-methyl-2,4-dioxo-3(2H)-quinazolinyl]methyl]-, trans-
- CBNumber:
- CB03416783
- Molecular Formula:
- C26H24F3N3O4
- Molecular Weight:
- 499.48
- MDL Number:
- MOL File:
- 1498300-35-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
QDVBJHFEZRTDHU-QAQDUYKDSA-N Chemical Properties, Uses, Production
Description
QQN-00358 is a novel potent and selective tankyrase (TNKS) inhibitor.
Uses
TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1].
References
[1] Qin D,et al. Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors. ACS Med Chem Lett. 2021 May 13;12(6):1005-1010. DOI:10.1021/acsmedchemlett.1c00160
QDVBJHFEZRTDHU-QAQDUYKDSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
QDVBJHFEZRTDHU-QAQDUYKDSA-N Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
