Benzenesulfonamide-3-boronic acid pinacol ester
- CAS No.
- 486422-08-6
- Chemical Name:
- Benzenesulfonamide-3-boronic acid pinacol ester
- Synonyms
- 3-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonaMide;3-Boronobenzenesulfonamide,pinacol ester;3-Sulfamoylphenylboronic Acid Pinacol Ester;Benzenesulfonamide-3-boronic acid pinacol ester;3-aMinosulfonyl-phenylboronic acid pinacol ester;3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide;Benzenesulfonamide, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborola...;Benzenesulfonamide, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- CBNumber:
- CB0346379
- Molecular Formula:
- C12H18BNO4S
- Molecular Weight:
- 283.15
- MDL Number:
- MFCD07781217
- MOL File:
- 486422-08-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2935909099 |
Benzenesulfonamide-3-boronic acid pinacol ester price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00I8PW | Benzenesulfonamide, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 95% | 486422-08-6 | 250mg | $14 | 2026-05-29 | Buy |
| aablocks | AA00I8PW | Benzenesulfonamide, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 95% | 486422-08-6 | 1g | $30 | 2026-05-29 | Buy |
| ACHEMBLOCK | T98051 | 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide 95% | 486422-08-6 | 5G | $195 | 2026-05-27 | Buy |
| ACHEMBLOCK | T98051 | 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide 95% | 486422-08-6 | 25G | $975 | 2026-05-27 | Buy |
| Crysdot | CD12068626 | 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide 95+% | 486422-08-6 | 1g | $188 | 2026-05-27 | Buy |
Benzenesulfonamide-3-boronic acid pinacol ester Chemical Properties, Uses, Production
Synthesis
89599-01-9
73183-34-3
486422-08-6
3-Bromobenzenesulfonamide (0.620 g, 2.63 mmol), potassium acetate (KOAc, 1.032 g, 10.52 mmol) and PdCl2(dppf)2 (0.100 g, 0.137 mmol) were used as raw materials, which were dissolved in dioxane (20 mL) under the protection of argon, and argon was blown up for 10 minutes to deoxygenate. Subsequently, bis(pinacolato)diboron (1.000 g, 3.94 mmol) was added to the reaction system, the reaction vessel was sealed, and the reaction was stirred at 110 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered through diatomaceous earth. The filtrate was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, gradient from 4:1 to 1:1) to afford the target product 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide (0.663 g, 89% yield) as a white solid. The product was characterized by NMR (DMSO-d6, HMDSO): δ 8.14 (ddd, J = 2.0, 1.1, 0.5 Hz, 1H), 7.93 (ddd, J = 7.9, 2.0, 1.3 Hz, 1H), 7.85 (td, J = 1.2, 7.4 Hz, 1H), 7.59 (ddd, J = 7.9, 7.4, 0.5 Hz, 1H), 1.32 (s, 12H).LCMS (ESI) m/z: 284.0 [M + H]+.
References
[1] Patent: WO2016/129983, 2016, A1. Location in patent: Page/Page column 35
[2] Patent: US2016/318895, 2016, A1. Location in patent: Paragraph 0339
Benzenesulfonamide-3-boronic acid pinacol ester Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Hebei Summedchem Co.,Ltd | 0319-5801333-8008 15630992918 | sales@summedchem.com | China | 1000 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai ShiXian Chemical Technology Co., Ltd. | 13764359345 | 990877971@qq.com | China | 1920 | 50 |
