2-Cyano-N-methyl-acetamide
- CAS No.
- 6330-25-2
- Chemical Name:
- 2-Cyano-N-methyl-acetamide
- Synonyms
- Entacapone Impurity 27;Entacapone Impurity 61;Methyl 2-Cyano Acetamide;N-Methyl-2-cyanoacetamide;2-Cyan-N-methyl-acetamide;2-Cyano-N-methyl-acetamide;N1-METHYL-2-CYANOACETAMIDE;N-(Cyanoacetyl)methylamine;Acetamide, 2-cyano-N-methyl-;4-bromo-N-propan-2-yl-1-pentanamine
- CBNumber:
- CB0348520
- Molecular Formula:
- C4H6N2O
- Molecular Weight:
- 98.1
- MDL Number:
- MFCD00090119
- MOL File:
- 6330-25-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 82 °C |
|---|---|
| Boiling point | 335.3±25.0 °C(Predicted) |
| Density | 1.044±0.06 g/cm3(Predicted) |
| vapor pressure | 0.009Pa at 25℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | 5.44±0.10(Predicted) |
| color | Pale Yellow |
| LogP | -1.96--0.445 at 25℃ |
| FDA UNII | 5AE9HP6RPU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38-22 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2926907090 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
2-Cyano-N-methyl-acetamide price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3781 | 2-Cyano-N-methylacetamide min. 98.0 % | 6330-25-2 | 5G | $66 | 2026-04-30 | Buy |
| TCI Chemical | M3781 | 2-Cyano-N-methylacetamide min. 98.0 % | 6330-25-2 | 25G | $198 | 2026-04-30 | Buy |
| Usbiological | 269848 | 2-Cyano-N-Methyl-Acetamide Asreported | 6330-25-2 | 500mg | $347 | 2026-06-03 | Buy |
| Usbiological | 269848 | 2-Cyano-N-Methyl-Acetamide Asreported | 6330-25-2 | 1g | $602 | 2026-06-03 | Buy |
| Usbiological | 269848 | 2-Cyano-N-Methyl-Acetamide Asreported | 6330-25-2 | 2g | $842 | 2026-06-03 | Buy |
2-Cyano-N-methyl-acetamide Chemical Properties, Uses, Production
Uses
2-Cyano-N-methylacetamide is used in the synthesis of pyridone compounds and benzimidazoles, for various pharmaceutical application.
Synthesis
105-56-6
74-89-5
6330-25-2
1. General procedure for the synthesis of 2-cyano-N-methylacetamide: 20 g (176.8 mmol) of ethyl cyanoacetate was added slowly and dropwise at 0 °C to a tetrahydrofuran (THF) solution of 10.9 g (353.6 mmol) of methylamine, which had been cooled to 0 °C. The reaction was completed with stirring. After the dropwise addition was completed, the reaction mixture was kept at 0 °C with continued stirring. Subsequently, the reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by recrystallization with toluene to give 16.8 g of beige solid product in 96% yield with a melting point of 99 °C.
References
[1] Patent: US2011/251194, 2011, A1. Location in patent: Page/Page column 14
[2] Patent: US2011/124643, 2011, A1. Location in patent: Page/Page column 14
[3] Patent: US2013/178472, 2013, A1. Location in patent: Paragraph 0228
[4] Marine Drugs, 2012, vol. 10, # 6, p. 1412 - 1421
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 12, p. 5350 - 5366
2-Cyano-N-methyl-acetamide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Giant chemicals | 请加QQ询价！ | 2720161014@qq.com | China | 715 | 56 |
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 971 | 68 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shangchem Co., Ltd. | +86-21-68182121 | China | 881 | 52 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1182 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
View Latest Price from 2-Cyano-N-methyl-acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-20 | 2-CYANO-N-METHYL-ACETAMIDE
6330-25-2
|
1KG | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2020-01-10 | 2-Cyano-N-methylacetamide
6330-25-2
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 2-CYANO-N-METHYL-ACETAMIDE
6330-25-2
- 98%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- 2-Cyano-N-methylacetamide
6330-25-2
- $1.00
- 99%
- Career Henan Chemical Co
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