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2-Amino-5-nitro-4-picoline

2-Amino-5-nitro-4-picoline structure

CAS No.: 21901-40-6

Chemical Name:: 2-Amino-5-nitro-4-picoline

Synonyms: 2-AMINO-4-METHYL-5-NITROPYRIDINE;4-methyl-5-nitropyridin-2-amine;2-AMINO-5-NITRO-4-PICOLINE;2-Amino-5-nitro-4-picoline,98%;2-AMiono-4Methyl-5Nitropyridine;4-Methyl-5-nitro-2-pyridinamine;2-Amino-4-Mythyl-5-NitroPyridine;2-Amino-5-nitro-4-methylpyridine;4-Methyl-5-nitropyridine-2-amine;2-Pyridinamine,4-methyl-5-nitro-

CBNumber:: CB0349709

Molecular Formula:: C6H7N3O2

Molecular Weight:: 153.14

MDL Number:: MFCD00010692

MOL File:: 21901-40-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:40:25

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2-Amino-5-nitro-4-picoline Properties

Melting point	223-225 °C (lit.)
Boiling point	276.04°C (rough estimate)
Density	1.3682 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Soluble in DMSO.
pka	3.44±0.24(Predicted)
form	Powder
color	Orange to yellow-brown
BRN	137695
InChI	InChI=1S/C6H7N3O2/c1-4-2-6(7)8-3-5(4)9(10)11/h2-3H,1H3,(H2,7,8)
InChIKey	GRBBNZYMXKTQAI-UHFFFAOYSA-N
SMILES	C1(N)=NC=C([N+]([O-])=O)C(C)=C1
CAS DataBase Reference	21901-40-6(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-20/21/22

Safety Statements

26-37/39-36/37/39-22-36

WGK Germany

HazardClass

IRRITANT

HS Code

29333999

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

2-Amino-5-nitro-4-picoline price More Price(79)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	290092	2-Amino-4-methyl-5-nitropyridine 98%	21901-40-6	1g	$40.7	2026-04-30	Buy
TCI Chemical	A1638	2-Amino-4-methyl-5-nitropyridine >98.0%(GC)(T)	21901-40-6	1g	$33	2026-04-30	Buy
TCI Chemical	A1638	2-Amino-4-methyl-5-nitropyridine >98.0%(GC)(T)	21901-40-6	5g	$130	2026-04-30	Buy
ChemScene	CS-W002060	4-Methyl-5-nitropyridin-2-amine ≥97%	21901-40-6	25g	$19	2026-06-04	Buy
ChemScene	CS-W002060	4-Methyl-5-nitropyridin-2-amine ≥97%	21901-40-6	100g	$29	2026-06-04	Buy

Product number	Packaging	Price	Buy
290092	1g	$40.7	Buy
A1638	1g	$33	Buy
A1638	5g	$130	Buy
CS-W002060	25g	$19	Buy
CS-W002060	100g	$29	Buy

2-Amino-5-nitro-4-picoline Chemical Properties, Uses, Production

Chemical Properties

orange to yellow-brown powder

Uses

2-Amino-4-methyl-5-nitropyridine was used in the preparation of matrix mixture required to study new technical developments for the direct tissue analysis of peptides.

General Description

The crystal structure of 2-amino-4-methyl-5-nitropyridine was elucidated.

Synthesis

695-34-1

21901-40-6

Example 9: Synthesis of 2-(1-aziridinyl)-4-carbamoyl-5-nitropyridine (Compound VI) Reagents and conditions: (i) HNO3/H2SO4; (ii) NaNO2; (iii) POCl3; (iv) Na2Cr2O7; (v) SOCl2/DMF, followed by NH4OH treatment; (vi) aziridine. Synthesis steps for compound 30: 1. cool concentrated sulfuric acid (240 mL) in an ice bath and slowly add raw compound 29 (2-amino-4-methylpyridine, 50 g, 0.462 mol), keeping the temperature at 0°C. 2. slowly add acid mixture prepared from concentrated sulfuric acid (98%, 55 mL) and concentrated nitric acid (72%, 55 mL) in a 1:1 volume ratio. 3. slowly heat to 50°C and react for 24 hours to ensure complete reaction. 4. Pour the reaction solution into 2 L of ice water, adjust the pH to 7 with a strong base, and filter to collect the precipitate. 5. Dry the filter cake to give 54 g of crude product. 6. The by-product 4-methyl-3-nitro-2-aminopyridine was removed by wet distillation and subsequently recrystallized in 95% ethanol to give 33 g of Compound 30 (2-amino-4-methyl-5-nitropyridine) with a melting point of 220-222 °C (Literature value: 220-222 °C). Yield: 46.6%.

References

[1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 12-13
[2] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0044
[3] Patent: WO2005/97129, 2005, A2. Location in patent: Page/Page column 176
[4] Patent: WO2012/103806, 2012, A1. Location in patent: Page/Page column 43

2-Amino-5-nitro-4-picoline Preparation Products And Raw materials

Raw materials

Nitric acid Sulfuric acid 4-Methylpyridin-2-amine

Preparation Products

3-Fluoropyridine-4-carboxylic acid ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 2-Methoxy-5-nitro-4-picoline 2-Bromo-5-nitro-4-picoline 7-Methyl-6-nitro-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester

2-Acetamido-5-amino-4-picoline

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2-Amino-5-nitro-4-picoline Suppliers

Global Suppliers ( 367)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Liaoning Tianhua Chemical Co., Ltd.	0418-6530555 2855550		China	338	69
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
ChemFuture PharmaTech (Jiangsu) Ltd	5108538618	suger.wang@chemfuture.com	China	832	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Liaoning Tianhua Chemical Co., Ltd.	69
INTATRADE GmbH	66
ChemFuture PharmaTech (Jiangsu) Ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65

View Latest Price from 2-Amino-5-nitro-4-picoline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	2-Amino-5-nitro-4-picoline 21901-40-6	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-08-20	2-Amino-5-nitro-4-picoline 21901-40-6	$1.10	1g	99.00%	100 Tons min	Dideu Industries Group Limited
2026-06-30	2-Amino-5-nitro-4-picoline 21901-40-6		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

2-Amino-5-nitro-4-picoline
21901-40-6
$5.00
98%
Henan Fengda Chemical Co., Ltd

2-Amino-5-nitro-4-picoline
21901-40-6
$1.10
99.00%
Dideu Industries Group Limited

2-Amino-5-nitro-4-picoline
21901-40-6
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-Amino-5-nitro-4-picoline Spectrum

2-Amino-5-nitro-4-picoline(21901-40-6)¹HNMR

21901-40-6 (2-Amino-5-nitro-4-picoline) Related Search:

Kresoxim-methyl 4-Methylpyridine 2-Bromo-5-nitropyridine 3-Amino-4-methylpyridine 2-Aminopyridine

4-Dimethylaminopyridine Methyl salicylate 2-Methyl-5-nitropyridine 4-Methylpyridin-2-amine Methylparaben

2-Amino-5-nitropyridine 3-Aminopyridine Methyl acetate Bensulfuron methyl Thiophanate-methyl

Tris(hydroxymethyl)aminomethane Metsulfuron methyl Methyl

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2-Amino-5-nitro-4-methylpyridine 2-Amino-4-Mythyl-5-NitroPyridine 2-AMINO-4-METHYL-5-NITRO PYRIDINE 98+% 2-AMINO-5-NITRO-4-PICOLINE (2-AMINO-4-METHYL-5-NITROPYRIDINE) 4-Methyl-5-nitro-2-pyridinamine 4-Methyl-5-nitropyridine-2-amine 4-methyl-5-nitropyridin-2-amine hydro chloride 2-Amino-5-nitro-4-picoline,98% 4-Methyl-5-nitro-pyridin-2-ylamine 2-Pyridinamine,4-methyl-5-nitro- 2-AMiono-4Methyl-5Nitropyridine 2-AMINO-5-NITRO-4-PICOLINE 2-Amino-4-methyl-5-nitropyridine > 2-Amino-5-nitro-4-picoline ISO 9001：2015 REACH 2-AMINO-4-METHYL-5-NITROPYRIDINE 4-methyl-5-nitropyridin-2-amine 21901-40-6 Heterocyclic Building Blocks Pyridines Building Blocks C6 Pyridine Pyridines, Pyrimidines, Purines and Pteredines Building Blocks Chemical Synthesis Heterocyclic Building Blocks Heterocycle-Pyridine series amine |nitro-compound compounds of pyridine Amino-pyridine series Amines Pyridines Pyridines derivates Heterocyclic Building Blocks bc0001 C6