- 2-Amino-5-nitro-4-picoline
-
- $5.00 / 1KG
-
2025-09-25
- CAS:21901-40-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
|
| | 2-Amino-5-nitro-4-picoline Basic information |
| | 2-Amino-5-nitro-4-picoline Chemical Properties |
| Melting point | 223-225 °C (lit.) | | Boiling point | 276.04°C (rough estimate) | | density | 1.3682 (rough estimate) | | refractive index | 1.6500 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Soluble in DMSO. | | form | Powder | | pka | 3.44±0.24(Predicted) | | color | Orange to yellow-brown | | BRN | 137695 | | InChI | InChI=1S/C6H7N3O2/c1-4-2-6(7)8-3-5(4)9(10)11/h2-3H,1H3,(H2,7,8) | | InChIKey | GRBBNZYMXKTQAI-UHFFFAOYSA-N | | SMILES | C1(N)=NC=C([N+]([O-])=O)C(C)=C1 | | CAS DataBase Reference | 21901-40-6(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-20/21/22 | | Safety Statements | 26-37/39-36/37/39-22-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29333999 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Amino-5-nitro-4-picoline Usage And Synthesis |
| Chemical Properties | orange to yellow-brown powder | | Uses | 2-Amino-4-methyl-5-nitropyridine was used in the preparation of matrix mixture required to study new technical developments for the direct tissue analysis of peptides. | | General Description | The crystal structure of 2-amino-4-methyl-5-nitropyridine was elucidated. | | Synthesis | Example 9: Synthesis of 2-(1-aziridinyl)-4-carbamoyl-5-nitropyridine (Compound VI)
Reagents and conditions: (i) HNO3/H2SO4; (ii) NaNO2; (iii) POCl3; (iv) Na2Cr2O7; (v) SOCl2/DMF, followed by NH4OH treatment; (vi) aziridine.
Synthesis steps for compound 30:
1. cool concentrated sulfuric acid (240 mL) in an ice bath and slowly add raw compound 29 (2-amino-4-methylpyridine, 50 g, 0.462 mol), keeping the temperature at 0°C.
2. slowly add acid mixture prepared from concentrated sulfuric acid (98%, 55 mL) and concentrated nitric acid (72%, 55 mL) in a 1:1 volume ratio.
3. slowly heat to 50°C and react for 24 hours to ensure complete reaction.
4. Pour the reaction solution into 2 L of ice water, adjust the pH to 7 with a strong base, and filter to collect the precipitate.
5. Dry the filter cake to give 54 g of crude product.
6. The by-product 4-methyl-3-nitro-2-aminopyridine was removed by wet distillation and subsequently recrystallized in 95% ethanol to give 33 g of Compound 30 (2-amino-4-methyl-5-nitropyridine) with a melting point of 220-222 °C (Literature value: 220-222 °C).
Yield: 46.6%. | | References | [1] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 12-13
[2] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0044
[3] Patent: WO2005/97129, 2005, A2. Location in patent: Page/Page column 176
[4] Patent: WO2012/103806, 2012, A1. Location in patent: Page/Page column 43 |
| | 2-Amino-5-nitro-4-picoline Preparation Products And Raw materials |
|