4,4-Dimethylcyclohexylamine
- CAS No.
- 20615-18-3
- Chemical Name:
- 4,4-Dimethylcyclohexylamine
- Synonyms
- 4,4-diMethylcyclohexan-1-aMine;4,4-Dimethylcyclohexylamine;4,4-DIMETHYLCYCLOHEXANAMINE;CyclohexylaMine,4,4-diMethyl-;CyclohexanaMine,4,4-diMethyl-;4-AMINO-1,1-DIMETHYLCYCLOHEXANE
- CBNumber:
- CB0353755
- Molecular Formula:
- C8H17N
- Molecular Weight:
- 127.23
- MDL Number:
- MFCD08460046
- MOL File:
- 20615-18-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P280-P305+P351+P338-P310 |
4,4-Dimethylcyclohexylamine price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 312415 | 4,4-Dimethylcyclohexanamine | 20615-18-3 | 250.00mg | $76 | 2026-05-19 | Buy |
| Matrix Scientific | 312415 | 4,4-Dimethylcyclohexanamine | 20615-18-3 | 1.00g | $195 | 2026-05-19 | Buy |
| Matrix Scientific | 312415 | 4,4-Dimethylcyclohexanamine | 20615-18-3 | 5.00g | $750 | 2026-05-19 | Buy |
| Synthonix | D22258 | 4,4-Dimethylcyclohexanamine 97.0% | 20615-18-3 | 100mg | $40 | 2026-05-06 | Buy |
| Synthonix | D22258 | 4,4-Dimethylcyclohexanamine 97.0% | 20615-18-3 | 250mg | $70 | 2026-05-06 | Buy |
4,4-Dimethylcyclohexylamine Chemical Properties, Uses, Production
Synthesis
4701-96-6
20615-18-3
The general procedure for the synthesis of 4,4-dimethylcyclohexylamine from 4,4-dimethylcyclohexanone oxime was as follows: 4,4-dimethylcyclohexanone oxime (10 g, 71 mmol, 1 equiv.) was dissolved in ethanol (100 mL) and Raney Ni catalyst (1 g, 10% w/w) was added. The reaction mixture was stirred under hydrogen atmosphere (50 psi) for 4 hours. Upon completion of the reaction, the catalyst was removed by filtration through a diatomaceous earth pad. Hydrochloric acid (1 M in H2O, 100 mL, 100 mmol, 1.4 eq.) was added to the filtrate and the resulting precipitate was collected by filtration and dissolved in water. The aqueous phase was washed with ether and alkalized to a strong base with potassium hydroxide pellets and subsequently extracted twice with dichloromethane. The organic phases were combined, dried over magnesium sulfate and concentrated in vacuum to afford 4,4-dimethylcyclohexylamine (8 g, 89% yield) as a clear oil, which can be used in the next reaction without further purification.
References
[1] Patent: WO2004/50619, 2004, A1. Location in patent: Page 78-79
[2] Patent: WO2014/37900, 2014, A1. Location in patent: Page/Page column 33
[3] Journal of medicinal chemistry, 1971, vol. 14, # 17, p. 600 - 614
[4] Journal of the Chemical Society [Section] B: Physical Organic, 1971, p. 1047 - 1050
4,4-Dimethylcyclohexylamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2284 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4555 | 58 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
| ShangHai Wisacheam Pharmaceutical Co., Ltd. | 13817485796 | tim@wisacheampharm.com | China | 3698 | 58 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
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